IP6K1 is essential for chromatoid body formation and temporal regulation ofTnp2andPrm2expression in mouse spermatids

MVB (multivesicular body) formation occurs when the limiting membrane of an endosome invaginates into the intraluminal space and buds into the lumen, bringing with it a subset of transmembrane cargoes. Exvagination of the endosomal membrane from the cytosol is topologically similar to the budding of retroviral particles and cytokinesis, wherein membranes bud away from the cytoplasm, and the machinery responsible for MVB sorting has been implicated in these phenomena. The AAA (ATPase associated with various cellular activities) Vps4 (vacuolar protein sorting 4) performs a critical function in the MVB sorting pathway. Vps4 appears to dissociate the ESCRTs (endosomal sorting complexes required for transport) from endosomal membranes during the course of MVB sorting, but it is unclear how Vps4 ATPase activity is synchronized with ESCRT release. We have investigated the mechanisms by which ESCRT components stimulate the ATPase activity of Vps4. These studies support a model wherein Vps4 activity is subject to spatial and temporal regulation via distinct mechanisms during MVB sorting.

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Thesis abstract Characterization of the nucleolar cycle and chromatoid body formation in the spermatogenesis of some vertebrate species

Genetics and Molecular Research ◽

10.4238/vol8-2ta017 ◽

2009 ◽

Vol 8 (2) ◽

pp. 456-457 ◽

Cited By ~ 1

Author(s):

R.L. Peruquetti

Keyword(s):

Vertebrate Species ◽

Chromatoid Body ◽

Body Formation ◽

Abstract Characterization ◽

Nucleolar Cycle

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Meiotic nucleolar cycle and chromatoid body formation during the rat (Rattus novergicus) and mouse (Mus musculus) spermiogenesis

Micron ◽

10.1016/j.micron.2007.02.009 ◽

2008 ◽

Vol 39 (4) ◽

pp. 419-425 ◽

Cited By ~ 23

Author(s):

Rita Luiza Peruquetti ◽

Isabella Mariana Assis ◽

Sebastião Roberto Taboga ◽

Maria Tercília Vilela de Azeredo-Oliveira

Keyword(s):

Mus Musculus ◽

Chromatoid Body ◽

Body Formation ◽

Nucleolar Cycle

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Relationship between the nucleolar cycle and chromatoid body formation in the spermatogenesis ofPhrynops geoffroanus(Reptilia Testudines)

Animal Cells and Systems ◽

10.1080/19768354.2011.615147 ◽

2012 ◽

Vol 16 (2) ◽

pp. 104-113

Author(s):

Rita L. Peruquetti ◽

Sebastiao R. Taboga ◽

Silvia R. Cabral ◽

Classius de Oliveira ◽

Maria T. Azeredo-Oliveira

Keyword(s):

Chromatoid Body ◽

Body Formation ◽

Nucleolar Cycle

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The rod-to-coccoid body transformation in cultures of Helicobacter pylori

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100160686 ◽

1990 ◽

Vol 48 (3) ◽

pp. 626-627

Author(s):

A. R. Crooker ◽

W. G. Kraft ◽

T. L. Beard ◽

M. C. Myers

Keyword(s):

Helicobacter Pylori ◽

Growth Cycle ◽

Negative Bacterium ◽

Body Formation ◽

Coccoid Form ◽

Spiral Form ◽

Prolonged Culture ◽

H Pylori ◽

Upper Gastrointestinal

Helicobacter pylori is a microaerophilic, gram-negative bacterium found in the upper gastrointestinal tract of humans. There is strong evidence that H. pylori is important in the etiology of gastritis; the bacterium may also be a major predisposing cause of peptic ulceration. On the gastric mucosa, the organism exists as a spiral form with one to seven sheathed flagella at one (usually) or both poles. Short spirals were seen in the first successful culture of the organism in 1983. In 1984, Marshall and Warren reported a coccoid form in older cultures. Since that time, other workers have observed rod and coccal forms in vitro; coccoid forms predominate in cultures 3-7 days old. We sought to examine the growth cycle of H. pylori in prolonged culture and the mode of coccoid body formation.

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The Effect of Agents which Modify Platelet Behaviour and of Magnesium Ions on Thrombus Formation In Vivo

Thrombosis and Haemostasis ◽

10.1055/s-0038-1666898 ◽

1979 ◽

Vol 42 (02) ◽

pp. 603-610 ◽

Cited By ~ 59

Author(s):

J H Adams ◽

J R A Mitchell

Keyword(s):

Thrombus Formation ◽

Cerebral Arteries ◽

Magnesium Ions ◽

Body Formation ◽

Inflammatory Agent ◽

Platelet Thrombus ◽

Magnesium Salts ◽

Higher Doses ◽

Do So

SummaryThe ability of potential anti-thrombotic agents to modify platelet-thrombus formation in injured cerebral arteries in the rabbit was tested. Low doses of heparin were without effect, while higher doses produced variable suppression of white body formation but at the expense of bleeding. Aspirin did not inhibit white body formation but another non-steroid anti-inflammatory agent, flurbiprofen was able to do so, as was the anti-gout agent, sulphinpyrazone. Magnesium salts both topically and parenterally, suppressed thrombus formation and increased the concentration of ADP which was required to initiate thrombus production at minor injury sites.

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