SUMO orchestrates multiple alternative DNA-protein crosslink repair pathways

2020 ◽  
Author(s):  
Vanessa Kellner
Keyword(s):  
Multiple Alternative ◽  
Repair Pathways ◽  
Crosslink Repair

scholarly journals SUMO orchestrates multiple alternative DNA-protein crosslink repair pathways

Cell Reports ◽  
2021 ◽  
Vol 37 (8) ◽  
pp. 110034
Author(s):  
Nataliia Serbyn ◽  
Ivona Bagdiul ◽  
Audrey Noireterre ◽  
Agnès H. Michel ◽  
Raymond T. Suhandynata ◽  
...  
Keyword(s):  
Multiple Alternative ◽  
Repair Pathways ◽  
Crosslink Repair

scholarly journals SUMO Orchestrates Multiple Alternative DNA-Protein Crosslink Repair Pathways

2020 ◽  
Author(s):  
Nataliia Serbyn ◽  
Ivona Bagdiul ◽  
Agnès H. Michel ◽  
Raymond T. Suhandynata ◽  
Huilin Zhou ◽  
...  
Keyword(s):  
Multiple Alternative ◽  
Repair Pathways ◽  
Crosslink Repair

Processing of anthracycline-DNA adducts via DNA replication and interstrand crosslink repair pathways

2012 ◽  
Vol 83 (9) ◽  
pp. 1241-1250 ◽  
Author(s):  
R.A. Bilardi ◽  
K.-I. Kimura ◽  
D.R. Phillips ◽  
S.M. Cutts
Keyword(s):  
Dna Replication ◽  
Dna Adducts ◽  
Interstrand Crosslink ◽  
Repair Pathways ◽  
Interstrand Crosslink Repair ◽  
Crosslink Repair

scholarly journals SUMO orchestrates multiple alternative DNA-protein crosslink repair pathways

2020 ◽  
Author(s):  
Nataliia Serbyn ◽  
Ivona Bagdiul ◽  
Agnès H. Michel ◽  
Raymond T. Suhandynata ◽  
Huilin Zhou ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Genome Integrity ◽  
Sumo Conjugation ◽  
Therapeutic Drugs ◽  
Sumo Ligase ◽  
Environmental Agents ◽  
Multiple Alternative ◽  
Repair Pathways ◽  
Endogenous Metabolites ◽  
Protein Crosslinks

SUMMARYSeveral endogenous metabolites, environmental agents, and therapeutic drugs promote formation of covalent DNA-protein crosslinks (DPCs). Persistent DPCs pose a serious threat to genome integrity and are eliminated by multiple repair pathways. Aberrant Top1 crosslinks to DNA, or Top1ccs, are processed by Tdp1 and Wss1 functioning in parallel pathways in Saccharomyces cerevisiae. It remains obscure how cells choose between these diverse mechanisms of DPC repair. Here we show that several SUMO biogenesis factors - Ulp1, Siz2, Slx5, Slx8 - control repair of Top1cc or an analogous DPC lesion. Genetic analysis reveals that SUMO promotes Top1cc processing in the absence of Tdp1 but has an inhibitory role if cells additionally lack Wss1. In the tdp1Δ wss1Δ mutant, the E3 SUMO ligase Siz2 stimulates sumoylation in the vicinity of the DPC, but not SUMO conjugation to Top1. This Siz2-dependent sumoylation delays DPC repair when cells progress through S and G2 phases. Our findings suggest that SUMO tunes available repair pathways to facilitate faithful DPC repair.

scholarly journals Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans

2017 ◽  
Vol 45 (16) ◽  
pp. 9467-9480 ◽  
Author(s):  
David M. Wilson ◽  
Matthias Rieckher ◽  
Ashley B. Williams ◽  
Björn Schumacher
Keyword(s):  
Caenorhabditis Elegans ◽  
Systematic Analysis ◽  
Repair Pathways ◽  
Development And Aging ◽  
Crosslink Repair

scholarly journals ERCC1 function in nuclear excision and interstrand crosslink repair pathways is mediated exclusively by the ERCC1-202 isoform

Cell Cycle ◽  
2013 ◽  
Vol 12 (20) ◽  
pp. 3298-3306 ◽  
Author(s):  
Luc Friboulet ◽  
Sophie Postel-Vinay ◽  
Tony Sourisseau ◽  
Julien Adam ◽  
Annabelle Stoclin ◽  
...  
Keyword(s):  
Interstrand Crosslink ◽  
Repair Pathways ◽  
Interstrand Crosslink Repair ◽  
Crosslink Repair

366-OR: TCF19 Promotes Functional Beta-Cell Mass and Proliferative Capacity by Regulating DNA Damage Repair Pathways

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 366-OR
Author(s):  
GRACE H. YANG ◽  
JEE YOUNG HAN ◽  
SUKANYA LODH ◽  
JOSEPH T. BLUMER ◽  
DANIELLE FONTAINE ◽  
...  
Keyword(s):  
Dna Damage ◽  
Beta Cell ◽  
Dna Damage Repair ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Proliferative Capacity ◽  
Damage Repair ◽  
Repair Pathways
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