Is Electron Beam Intraoperative Radiotherapy (ELIOT) Safe in Pregnant Women with Early Breast Cancer? In Vivo Dosimetry to Assess Fetal Dose

2009 ◽  
Vol 16 (1) ◽  
Author(s):  
Viviana Galimberti ◽  
Mario Ciocca ◽  
Maria Cristina Leonardi ◽  
Vanna Zanagnolo ◽  
Baratella Paola ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Electron Beam ◽  
Pregnant Women ◽  
Early Breast Cancer ◽  
Intraoperative Radiotherapy ◽  
In Vivo Dosimetry ◽  
Fetal Dose

scholarly journals Electron Beam Intraoperative Radiotherapy (ELIOT) in Pregnant Women with Breast Cancer: From in Vivo Dosimetry to Clinical Practice

Breast Care ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. 396-400 ◽  
Author(s):  
Maria Leonardi ◽  
Agnese Cecconi ◽  
Rosa Luraschi ◽  
Elena Rondi ◽  
Federica Cattani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Electron Beam ◽  
Pregnant Women ◽  
Intraoperative Radiotherapy ◽  
Pregnant Patient ◽  
Breast Conserving Surgery ◽  
In Vivo Dosimetry ◽  
Breast Cancer Patients ◽  
Tumor Bed

Background: The aim of this study was to confirm our preliminary results with in vivo dosimetry in non-pregnant breast cancer patients receiving electron beam intraoperative radiotherapy (ELIOT) and to report on the first treatment in a pregnant woman. Patients and Methods: Following our previous experience, 5 non-pregnant patients receiving ELIOT to the tumor bed after breast-conserving surgery (BCS) were studied with thermoluminescent dosimeters positioned in the subdiaphragmatic region, within the uterus, and in the ovarian region. In December 2011, the first pregnant breast cancer patient underwent BCS and ELIOT (21 Gy at 90% isodose) during the 15th week of gestation. Results: The mean dose to the subdiaphragmatic external region in the 5 non-pregnant patients was 5.57 mGy, while pelvic measurements were below 1 mGy. The actual dosimetry of the pregnant patient showed a mean subdiaphragmatic dose of 4.34 mGy, a mean suprapubic dose of 1.64 mGy, and mean ovarian doses of 1.48 mGy (right-sided) and 1.44 mGy (left-sided). The expected dose to the fetus was estimated as 0.84 mGy (0.004% of the prescribed dose). Conclusion: ELIOT as an anticipated boost to the breast could be considered in pregnant women in the early second trimester, postponing whole-breast irradiation after delivery.

In vivo dosimetry using radiochromic films during intraoperative electron beam radiation therapy in early-stage breast cancer

2003 ◽  
Vol 69 (3) ◽  
pp. 285-289 ◽  
Author(s):  
Mario Ciocca ◽  
Roberto Orecchia ◽  
Cristina Garibaldi ◽  
Elena Rondi ◽  
Alberto Luini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Electron Beam ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
In Vivo Dosimetry ◽  
Beam Radiation ◽  
Radiochromic Films ◽  
Electron Beam Radiation

In Vivo Dosimetry for Single-Fraction Targeted Intraoperative Radiotherapy (TARGIT) for Breast Cancer

2012 ◽  
Vol 82 (5) ◽  
pp. e819-e824 ◽  
Author(s):  
David J. Eaton ◽  
Bronagh Best ◽  
Chris Brew-Graves ◽  
Stephen Duck ◽  
Tabasom Ghaus ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Intraoperative Radiotherapy ◽  
In Vivo Dosimetry ◽  
Single Fraction

In vivo dosimetry for intraoperative radiotherapy for breast cancer

2014 ◽  
Vol 30 ◽  
pp. e142
Author(s):  
B. Giacobbi ◽  
M. Ferre ◽  
A. Canals ◽  
D. Lavielle ◽  
C. Chatry ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Intraoperative Radiotherapy ◽  
In Vivo Dosimetry

MICROMOSFET IN-VIVO DOSIMETRY IN EARLY-BREAST CANCER IORT: REPORT ON THREE YEARS OF PRACTICE

2009 ◽  
Vol 92 ◽  
pp. S231
Author(s):  
S. Andreoli ◽  
M. Fortunato ◽  
R. Moretti ◽  
A. Personeni ◽  
G. Gritti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
In Vivo Dosimetry

In vivo dosimetry using radiochromic films (EBT-2) during intraoperative radiotherapy

2016 ◽  
Vol 15 (4) ◽  
pp. 378-384 ◽  
Author(s):  
Zahra Rahimzade Yekta ◽  
Seied Rabi Mehdi Mahdavi ◽  
Hamid Reza Baghani ◽  
Mostafa Robatjazi ◽  
Ahmad Mostaar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Stage ◽  
Intraoperative Radiotherapy ◽  
Surgical Excision ◽  
In Vivo Dosimetry ◽  
Mean Deviation ◽  
Beam Radiation ◽  
Dose Measurements ◽  
Delivered Dose

AbstractBackgroundIntraoperative radiotherapy is a method of choice to deliver a critical radiation dose to the tumour bed immediately after surgical excision.AimThe purpose of this work is to check the dose delivered to the patients during intraoperative electron beam radiation therapy (IOERT) in the conservative treatment of breast cancer, by means of reference dose measurement using radiochromic (EBT-2) films.Material and methodsNinety patients with early-stage breast cancer underwent exclusive IOERT to the tumour bed using a LIAC linear accelerator. Absolute dose measurements were done with film pieces. After irradiation, the pixel values of the films were obtained via MATLAB and ImageJ softwares. Calibration curve was also used for calculating net optical density. Expected dose was compared to the patient delivered dose.ResultsThe mean deviation of the delivered dose from the expected one was 2·56% that is well in the accepted criteria. Only in one case, there was a larger deviation due to barometer miscalibration.FindingsEBT-2 film response is independent from dose-per-pulse and as it was shown in this study it can be robustly used during breast IOERT for dosimetric and also positioning verifications.

scholarly journals In vivo dosimetry and acute toxicity in breast cancer patients undergoing intraoperative radiotherapy as boost

2017 ◽  
Vol 35 (2) ◽  
pp. 121-128 ◽  
Author(s):  
Jason Joon Bock Lee ◽  
Jinhyun Choi ◽  
Sung Gwe Ahn ◽  
Joon Jeong ◽  
Ik Jae Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Acute Toxicity ◽  
Cancer Patients ◽  
Intraoperative Radiotherapy ◽  
In Vivo Dosimetry ◽  
Breast Cancer Patients
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