Sporadic Small (≤20 mm) Nonfunctioning Pancreatic Neuroendocrine Neoplasm: is the Risk of Malignancy Negligible When Adopting a More Conservative Strategy? A Systematic Review and Meta-analysis

2017 ◽  
Vol 24 (9) ◽  
pp. 2603-2610 ◽  
Author(s):  
Claudio Ricci ◽  
Riccardo Casadei ◽  
Giovanni Taffurelli ◽  
Carlo Alberto Pacilio ◽  
Davide Campana ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Neuroendocrine Neoplasm ◽  
Conservative Strategy ◽  
Pancreatic Neuroendocrine Neoplasm ◽  
Risk Of Malignancy

scholarly journals A Systematic review and meta-analysis on the role of palliative primary resection for pancreatic neuroendocrine neoplasm with liver metastases

HPB ◽  
2018 ◽  
Vol 20 (3) ◽  
pp. 197-203 ◽  
Author(s):  
Stefano Partelli ◽  
Roberto Cirocchi ◽  
Paola M.V. Rancoita ◽  
Francesca Muffatti ◽  
Valentina Andreasi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Metastases ◽  
Meta Analysis ◽  
Primary Resection ◽  
Neuroendocrine Neoplasm ◽  
Pancreatic Neuroendocrine Neoplasm

scholarly journals Prevalence of focal incidental breast uptake on FDG-PET/CT and risk of malignancy: a systematic review and meta-analysis

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Else Marie Aarstad ◽  
Petter Nordhaug ◽  
Mohammad Naghavi-Behzad ◽  
Lisbet Brønsro Larsen ◽  
Oke Gerke ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fdg Pet ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Previous History ◽  
Fdg Uptake ◽  
Pooled Prevalence ◽  
Pet Ct ◽  
Risk Of Malignancy ◽  
Fdg Pet Ct

Abstract Background FDG-PET/CT is increasingly used for oncologic and inflammatory diseases. Focal incidental FDG uptake occurs rarely in breast tissue but has often significant consequences. This study aimed to systematically review literature regarding focal incidental breast uptake (FIBU) on FDG-PET/CT in order to yield an update on the prevalence and risk of malignancy for FIBU. Methods A systematic search for relevant articles published between 2012 and 2018 was performed through MEDLINE, Embase, and Cochrane databases. Studies addressing the detection of FIBU in patients without a previous history of breast malignancy were included. The QUADAS-2 was used for quality assessment, and eligible data were pooled using a fixed-effects model. I2 was calculated for the heterogeneity between studies. Results Eight studies containing 180,002 scans were included in the systematic review. The median prevalence of FIBU for both genders was 0.52% (range 0.18–22.5%). Prevalence for women was mentioned separately in five studies and varied from 0.51 to 23.5%. One study reporting a high prevalence was based on patients being staged for known malignancy, and the word “breast” was used in the search, which may have caused selection bias. Data from four studies were eligible for meta-analysis. A high degree of heterogeneity was observed for prevalence data (I2 of 97.5%), while moderate heterogeneity was observed for data on malignancy risk assessment (I2 of 62.8%). The pooled prevalence of FIBU in women was 0.61% (range 0.56–0.66%), and the pooled prevalence of malignancy of FIBUs was 38.7% (range 34.4–43.0%). The most commonly detected malignancy was invasive ductal carcinoma. Conclusion FIBU occurs rarely on FDG-PET/CT for female patients but yields a high risk of malignancy according to the results of published papers. Therefore, it should be considered relevant to further elucidate patients with incidentally detected FDG uptake in breast in clinical practice.

Small versus large non functioning pancreatic endocrine tumor: Is the risk of malignancy negligible in small tumors? Systematic review and meta-analysis

Pancreatology ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. S77
Author(s):  
Giovanni Taffurelli ◽  
Claudio Ricci ◽  
Donatella Santini ◽  
Davide Campana ◽  
Valentina Ambrosini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Endocrine Tumor ◽  
Pancreatic Endocrine Tumor ◽  
Risk Of Malignancy

scholarly journals The risk of malignancy of unilocular ovarian cysts: a systematic review and meta-analysis

2019 ◽  
Author(s):  
Laura Buggio ◽  
Dhouha Dridi ◽  
Maria Pina Frattaruolo ◽  
Marco Reschini ◽  
Eugenia Di Loreto ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Ovarian Cysts ◽  
Risk Of Malignancy

scholarly journals Calcitonin-secreting neuroendocrine neoplasms of the lung: a systematic review and narrative synthesis

2021 ◽  
Vol 10 (4) ◽  
pp. 447-461
Author(s):  
David C Llewellyn ◽  
Rajaventhan Srirajaskanthan ◽  
Royce P Vincent ◽  
Catherine Guy ◽  
Eftychia E Drakou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Meta Analysis ◽  
A Priori ◽  
Neuroendocrine Neoplasm ◽  
Neuroendocrine Neoplasms ◽  
Cochrane Central Register ◽  
Medullary Thyroid ◽  
Stimulation Tests

Calcitonin-secreting neuroendocrine neoplasms of the lung are rare, with few cases reported in the literature. Differentiating between medullary thyroid carcinoma and an ectopic source of calcitonin secretion can represent a complex diagnostic conundrum for managing physicians, with cases of unnecessary thyroidectomy reported in the literature. This manuscript reports a case of ectopic hypercalcitonaemia from a metastatic neuroendocrine neoplasm of the lung with concurrent thyroid pathology and summarises the results of a systematic review of the literature. Medical Literature Analysis and Retrieval System Online, Excerpta Medica, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov and SCOPUS databases were systematically and critically appraised for all peer reviewed manuscripts that suitably fulfilled the inclusion criteria established a priori. The protocol for this systematic review was developed according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols, and followed methods outlined in The Cochrane Handbook for Systematic Reviews of Interventions. This systematic review is registered with PROSPERO. It is vital to consider diagnoses other than medullary thyroid carcinoma when presented with a patient with raised calcitonin, as it is not pathognomonic of medullary thyroid carcinoma. Lung neuroendocrine neoplasms can appear similar to medullary thyroid carcinoma histologically, they can secrete calcitonin and metastasize to the thyroid. Patients with medullary thyroid carcinoma may show stimulated calcitonin values over two or more times above the basal values, whereas calcitonin-secreting neuroendocrine neoplasms may or may not show response to stimulation tests. The present review summarises existing evidence from cases of ectopic hypercalcitonaemia to lung neuroendocrine neoplasms.

scholarly journals DIAGNOSIS IN ENDOCRINOLOGY: Quantification of cancer risk of each clinical and ultrasonographic suspicious feature of thyroid nodules: a systematic review and meta-analysis

2014 ◽  
Vol 170 (5) ◽  
pp. R203-R211 ◽  
Author(s):  
Paolo Campanella ◽  
Francesca Ianni ◽  
Carlo Antonio Rota ◽  
Salvatore Maria Corsello ◽  
Alfredo Pontecorvi
Keyword(s):  
Systematic Review ◽  
Family History ◽  
Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Meta Analysis ◽  
Halo Sign ◽  
Study Characteristics ◽  
Risk Of Malignancy ◽  
History Of ◽  
Meta Regression Analysis

ObjectiveIn order to quantify the risk of malignancy of clinical and ultrasonographic features of thyroid nodules (TNs), we did a systematic review and meta-analysis of published studies.MethodsWe did a literature search in MEDLINE for studies published from 1st January 1989 until 31st December 2012. Studies were considered eligible if they investigated the association between at least one clinical/ultrasonographic feature and the risk of malignancy, did not have exclusion criteria for the detected nodules, had histologically confirmed the diagnoses of malignancy, and had a univariable analysis available. Two reviewers independently extracted data on study characteristics and outcomes.ResultsThe meta-analysis included 41 studies, for a total of 29 678 TN. A higher risk of malignancy expressed in odds ratio (OR) was found for the following: nodule height greater than width (OR: 10.15), absent halo sign (OR: 7.14), microcalcifications (OR: 6.76), irregular margins (OR: 6.12), hypoechogenicity (OR: 5.07), solid nodule structure (OR: 4.69), intranodular vascularization (OR: 3.76), family history of thyroid carcinoma (OR: 2.29), nodule size ≥4 cm (OR: 1.63), single nodule (OR: 1.43), history of head/neck irradiation (OR: 1.29), and male gender (OR: 1.22).Interestingly, meta-regression analysis showed a higher risk of malignancy for hypoechoic nodules in iodine-sufficient than in iodine-deficient geographical areas.ConclusionsThe current meta-analysis verified and weighed out each suspicious clinical and ultrasonographic TN feature. The highest risk was found for nodule height greater than width, absent halo sign, and microcalcifications for ultrasonographic features and family history of thyroid carcinoma for clinical features. A meta-analysis-derived grading system of TN malignancy risk, validated on a large prospective cohort, could be a useful tool in TN diagnostic work-up.

scholarly journals Impact of non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) on risk of malignancy in patients undergoing lobectomy/thyroidectomy for suspected malignancy or malignant fine-needle aspiration cytology findings: a systematic review and meta-analysis

2019 ◽  
Vol 181 (4) ◽  
pp. 389-396 ◽  
Author(s):  
Massimo Bongiovanni ◽  
William C Faquin ◽  
Luca Giovanella ◽  
Cosimo Durante ◽  
Peter Kopp ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Thyroid Neoplasms ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Diagnostic Categories ◽  
Non Invasive ◽  
Risk Of Malignancy ◽  
Needle Aspiration Cytology ◽  
Nuclear Features

Objective The second version of The Bethesda System for Reporting Thyroid Cytopathology endorsed the introduction of non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) as a distinct entity with low malignant potential into clinical practice. Consequently, the risk of malignancy (ROM) of cytological diagnoses has changed, but the magnitude of the change remains uncertain. The present systematic review was undertaken to obtain more robust information about the true impact of NIFTP on the ROM among patients undergoing surgery following a fine-needle aspiration cytology (FNAC) diagnosis of suspicious for malignancy (Bethesda V) or malignant (Bethesda VI). As they are managed surgically, these two diagnostic categories are the primary entities that are clinically impacted by the advent of NIFTP. Design Systematic review and meta-analysis. Methods A comprehensive literature search of online databases was performed in November 2018. The search was conducted looking for data of histologically proven NIFTP with preoperative FNAC. Results One-hundred fifty-seven articles were identified and nine were included in the study. Overall, there were 13,752 thyroidectomies with a cancer prevalence of 45.7%. When NIFTP was considered non-malignant, the pooled risk difference for ROM was 5.5%. Applying meta-analysis, the pooled prevalence of NIFTP among nodules with FNAC of Bethesda V or Bethesda VI was 14 and 3%, respectively. Conclusion This meta-analysis shows that the inclusion of NIFTP leads to a reduction in the ROM for the Bethesda V and Bethesda VI FNAC diagnostic categories by 14 and 3%, respectively. Clinicians should be aware of these data to avoid overtreatment.

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