Marked Inhibitory Effects of Extracts from Barley-Koji Miso Encapsulated in Hybrid Liposomes on the Growth of Human Stomach Tumor Cells in Vitro

2005 ◽  
Vol 34 (3) ◽  
pp. 370-371 ◽  
Author(s):  
Yutaka Kadota ◽  
Taiki Ibuki ◽  
Koichi Goto ◽  
Yoko Matsumoto ◽  
Ryuichi Ueoka
Keyword(s):  
Tumor Cells ◽  
Human Stomach ◽  
Inhibitory Effects ◽  
Stomach Tumor

Inhibitory Effects of Extracts from Shochu Distillation Remnants on the Growth of Human Stomach Tumor Cells

2005 ◽  
Vol 38 (2) ◽  
pp. 154-157 ◽  
Author(s):  
Yutaka Kadota ◽  
Sigeru Hirose ◽  
Haruyuki Iefuji ◽  
Taku Matsushita ◽  
Yoko Matsumoto ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Human Stomach ◽  
Inhibitory Effects ◽  
Stomach Tumor

scholarly journals Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas

Toxins ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 157 ◽  
Author(s):  
Adriana Tomoko Nishiya ◽  
Marcia Kazumi Nagamine ◽  
Ivone Izabel Mackowiak da Fonseca ◽  
Andrea Caringi Miraldo ◽  
Nayra Villar Scattone ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Evaluation Criteria ◽  
Anthrax Toxin ◽  
Treatment Modalities ◽  
Inhibitory Effects ◽  
Upa Receptor ◽  
New Treatment ◽  
Oral Malignancy

Canine oral mucosal melanomas (OMM) are the most common oral malignancy in dogs and few treatments are available. Thus, new treatment modalities are needed for this disease. Bacillus anthracis (anthrax) toxin has been reengineered to target tumor cells that express urokinase plasminogen activator (uPA) and metalloproteinases (MMP-2), and has shown antineoplastic effects both, in vitro and in vivo. This study aimed to evaluate the effects of a reengineered anthrax toxin on canine OMM. Five dogs bearing OMM without lung metastasis were included in the clinical study. Tumor tissue was analyzed by immunohistochemistry for expression of uPA, uPA receptor, MMP-2, MT1-MMP and TIMP-2. Animals received either three or six intratumoral injections of the reengineered anthrax toxin prior to surgical tumor excision. OMM samples from the five dogs were positive for all antibodies. After intratumoral treatment, all dogs showed stable disease according to the canine Response Evaluation Criteria in Solid Tumors (cRECIST), and tumors had decreased bleeding. Histopathology has shown necrosis of tumor cells and blood vessel walls after treatment. No significant systemic side effects were noted. In conclusion, the reengineered anthrax toxin exerted inhibitory effects when administered intratumorally, and systemic administration of this toxin is a promising therapy for canine OMM.

scholarly journals Inhibitory effects of adenovirus mediated Akt1 and PIK3R1 shRNA on the growth of malignant tumor cells in vitro and in vivo

2009 ◽  
Vol 8 (11) ◽  
pp. 1002-1009 ◽  
Author(s):  
Yanchao Fu ◽  
Qingyu Zhang ◽  
Chunsheng Kang ◽  
Jing Zhang ◽  
Kairu Zhang ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Malignant Tumor ◽  
Inhibitory Effects

scholarly journals Inhibitory Effects of Extracts from Peels of Citrus natsudaidai Encapsulated in Hybrid Liposomes on the Growth of Tumor Cells in Vitro

2004 ◽  
Vol 27 (9) ◽  
pp. 1465-1467 ◽  
Author(s):  
Yutaka Kadota ◽  
Chiho Taniguchi ◽  
Shigeo Masuhara ◽  
Shinjiro Yamamoto ◽  
Shintaro Furusaki ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Inhibitory Effects ◽  
Growth Of Tumor

Enhanced inhibitory effects of extracts from Ginkgo biloba L. leaves encapsulated in hybrid liposomes on the growth of tumor cells in vitro

2002 ◽  
Vol 12 (2) ◽  
pp. 125-130 ◽  
Author(s):  
Shinjiro Yamamoto ◽  
Koji Nakano ◽  
Chihiro Ishikawa ◽  
Megumi Yamamoto ◽  
Yoko Matsumoto ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Ginkgo Biloba ◽  
Inhibitory Effects ◽  
Growth Of Tumor
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