scholarly journals Repeated Administration of Kupffer Cells-Targeting Nanoantioxidant Ameliorates Liver Fibrosis in an Experimental Mouse Model

2020 ◽  
Vol 43 (1) ◽  
pp. 93-101
Author(s):  
Hitoshi Maeda ◽  
Yuki Minayoshi ◽  
Shota Ichimizu ◽  
Yuki Mizuta ◽  
Taisei Nagasaki ◽  
...  
2012 ◽  
Vol 36 (1) ◽  
pp. 152-158 ◽  
Author(s):  
April M. Chow ◽  
Darwin S. Gao ◽  
Shu Juan Fan ◽  
Zhongwei Qiao ◽  
Frank Y. Lee ◽  
...  

2013 ◽  
Vol 48 (1) ◽  
pp. 46-54 ◽  
Author(s):  
April M. Chow ◽  
Mingqian Tan ◽  
Darwin S. Gao ◽  
Shu Juan Fan ◽  
Jerry S. Cheung ◽  
...  

2012 ◽  
Vol 61 (4) ◽  
pp. 417-425 ◽  
Author(s):  
Yin Tang ◽  
Xue-Feng Xia ◽  
Yun Zhang ◽  
Bing-Feng Huang ◽  
Tao Ma ◽  
...  

2004 ◽  
Vol 4 (1) ◽  
Author(s):  
Fatih M Uckun ◽  
Alexander S Petkevich ◽  
Alexei O Vassilev ◽  
Heather E Tibbles ◽  
Leonid Titov

2006 ◽  
Vol 20 (2) ◽  
pp. 228-236 ◽  
Author(s):  
Michel A. Bartoli ◽  
Federico E. Parodi ◽  
Jack Chu ◽  
Monica B. Pagano ◽  
Dongli Mao ◽  
...  

Acta Naturae ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 106-109
Author(s):  
Alexander R. Kim ◽  
Ekaterina N. Pavlova ◽  
Viktor E. Blokhin ◽  
Vsevolod V. Bogdanov ◽  
Michael V. Ugrumov

Early (preclinical) diagnosis of Parkinsons disease (PD) is a major challenge in modern neuroscience. The objective of this study was to experimentally evaluate a diagnostic challenge test with monoiodotyrosine (MIT), an endogenous inhibitor of tyrosine hydroxylase. Striatal dopamine was shown to decrease by 34% 2 h after subcutaneous injection of 100 mg/kg MIT to intact mice, with the effect not being amplified by a further increase in the MIT dose. The selected MIT dose caused motor impairment in a neurotoxic mouse model of preclinical PD, but not in the controls. This was because MIT reduced striatal dopamine to the threshold of motor symptoms manifestation only in PD mice. Therefore, using the experimental mouse model of preclinical PD, we have shown that a MIT challenge test may be used to detect latent nigrostriatal dysfunction.


2014 ◽  
Vol 14 (Suppl 3) ◽  
pp. O20 ◽  
Author(s):  
Sudhanshu Abhishek ◽  
Amod Gupta ◽  
Indu Verma

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