scholarly journals Alkylated Pyrimidine Derivatives as Antiviral Agents. I. Syntheses and Antiviral Screening of Alkylpyrimidine and 5-Alkyluracil Nucleoside

1970 ◽  
Vol 18 (2) ◽  
pp. 261-268 ◽  
Author(s):  
MASAKO MURAOKA ◽  
ATSUSHI TAKADA ◽  
TAKEO UEDA
Keyword(s):  
Antiviral Agents ◽  
Pyrimidine Derivatives

Pyrazolo[3,4-d]pyrimidine derivatives containing a Schiff base moiety as potential antiviral agents

2018 ◽  
Vol 28 (17) ◽  
pp. 2979-2984 ◽  
Author(s):  
Yan-Yan Wang ◽  
Fang-Zhou Xu ◽  
Yun-Ying Zhu ◽  
Baoan Song ◽  
Dexia Luo ◽  
...  
Keyword(s):  
Schiff Base ◽  
Antiviral Agents ◽  
Pyrimidine Derivatives ◽  
Base Moiety

In vitro Activity of the Novel Pyrimidines and Their Condensed Derivatives Against Poliovirus

2019 ◽  
Vol 15 (5) ◽  
pp. 582-591 ◽  
Author(s):  
Roman Solomyannyi ◽  
Sergii Slivchuk ◽  
Donald Smee ◽  
Jung-ae Choi ◽  
Eduard Rusanov ◽  
...  
Keyword(s):  
Morphological Changes ◽  
Biological Activities ◽  
Antiviral Agents ◽  
Vitro Activity ◽  
In Vitro Activity ◽  
Pyrimidine Derivatives ◽  
African Green Monkey Kidney ◽  
Dna And Rna ◽  
Type 3

Background: Substituted pyrimidine derivatives (non-nucleoside) are found to be associated with various biological activities. The various substituted pyrimidines are also having significant in vitro activity against different DNA and RNA viruses. The present study focuses on the anti-PV activity of new pyrimidines and their condensed derivatives. Methods: A series of novel pyrimidines and their condensed derivatives were synthesized and their structures were confirmed by spectral data. Their antiviral activities against poliovirus type 3 (PV-3) were evaluated in vitro. In cell culture, morphological changes observed in cells infected with polioviruses, including cell rounding and detachment from the substrate, are generally termed cytopathic effects (CPE). The effects of synthetic pyrimidines on PV amplification in a culture of the heteroploid cell line, Vero 76 (African green monkey kidney cells) were investigated. Results: Bioassays in vitro showed that one of seven synthesized compounds, 7-(Benzenesulfonyl)-5- benzyl-N-(prop-2-en-1-yl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine, has potent antiviral activity against PV-3 (EC50 = 0.75 μM). The selectivity index of this compound is similar to that of pirodavir. Conclusion: The need for antiviral agents to treat PV-associated diseases remains great, but few options currently exist. Here we show that substituted pyrimidine derivatives are a promising structure class of chemical compounds for the development of antiviral drugs against PV infections.

New chlorinated daphnane diterpenoids orthoester from Trigonostemon cherrieri as potent antiviral agents

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
M Bourjot ◽  
PM Allard ◽  
MT Martin ◽  
P Leyssen ◽  
F Guéritte ◽  
...  
Keyword(s):  
Antiviral Agents

Synthesis of Some New Tetracyclic Pyrimidine Derivatives Using Exocyclic α,β-Unsaturated Ketone and Evaluation of Their Antitumor Activities

2016 ◽  
Vol 12 (8) ◽  
pp. 311-317
Author(s):  
Kamelia El-Mahdy
Keyword(s):  
Antitumor Activity ◽  
Spectroscopic Data ◽  
Acid Hydrazide ◽  
Chloroacetic Acid ◽  
Equimolar Amount ◽  
Unsaturated Ketone ◽  
Cyanoacetic Acid ◽  
Antitumor Activities ◽  
Pyrimidine Derivatives ◽  
Cyanoacetic Acid Hydrazide

Thiazolopyrimidine 2 was obtained from the reaction of dihydropyrimidinone with chloroacetic acid and benzaldehyde. Thiazolopyrimidine 2 containing an α,β-unsaturated ketonic function [-CH=CH-CO-] has been used as a component of Michael addition with an equimolar amount of dinucleophiles to give a series of novel tetracyclic pyrimidine derivatives. Treatment of thiazolopyrimidine 2 with uracil, aminotriazole, cyanoacetic acid hydrazide, o-phenylenediamine or diaminopyridine afforded the corresponding pyridopyrimidine, triazolopyrimidine, pyrazolone, benzodiazepine and triazepine derivative, respectively. The detailed synthesis, spectroscopic data, and antitumor activity for synthesized compounds were reported.

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