scholarly journals Protective effect of molybdenum on the acute toxicity of mercuric chloride. III.

1984 ◽  
Vol 32 (6) ◽  
pp. 2316-2324 ◽  
Author(s):  
TOSHIAKI KOIZUMI ◽  
YASUHIRO YAMANE
Keyword(s):  
Acute Toxicity ◽  
Protective Effect ◽  
Mercuric Chloride

Protective effect of sulfhydryl compounds on acute toxicity of morphinone

Life Sciences ◽  
1982 ◽  
Vol 30 (13) ◽  
pp. 1121-1127 ◽  
Author(s):  
Kunisuke Nagamatsu ◽  
Yasumasa Kido ◽  
Tadao Terao ◽  
Takashi Ishida ◽  
Satoshi Toki
Keyword(s):  
Acute Toxicity ◽  
Protective Effect ◽  
Sulfhydryl Compounds

scholarly journals Evaluation of Safety and Protective Effect of Combined Extract ofCissampelos pareiraandAnethum graveolens(PM52) against Age-Related Cognitive Impairment

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Wipawee Thukham-mee ◽  
Jintanaporn Wattanathorn
Keyword(s):  
Cognitive Impairment ◽  
Acute Toxicity ◽  
Protective Effect ◽  
Underlying Mechanism ◽  
Food Supplement ◽  
Anethum Graveolens ◽  
Neuron Density ◽  
Age Related ◽  
Male Wistar Rats ◽  
Oecd Guideline

The present study aimed to determine acute toxicity, the protective effect, and underlying mechanism of PM52, a combined extract ofCissampelos pareiraandAnethum graveolens,against age-related cognitive impairment in animal model of age-related cognitive impairment. PM52 was determined as acute toxicity according to OECD guideline. Male Wistar rats, weighing 180–220 g, were orally given PM52 at doses of 2, 10, and 50 mg/kg at a period of 14 days before and 7 days after the bilateral administration of AF64A via intracerebroventricular route. All animals were assessed according to spatial memory, neuron density, MDA level, the activities of SOD, CAT, GSH-Px, and AChEI effect in hippocampus. It was found that all doses of PM52 could attenuate memory impairment and neurodegeneration in hippocampus. The possible mechanisms might occur via the suppression of AChE and the decreased oxidative stress in hippocampus. Therefore, our data suggest that PM52 may serve as food supplement to protect against age-related cognitive impairment such as mild cognitive impairment (MCI) and early phase of Alzheimer’s disease. However, further researches are still essential.

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