scholarly journals Protective effect of sodium molybdate against the acute toxicity of mercuric chloride in rat.VI. The mechanism of stimulative action of sodium molybdate on urinary excretion of mercury.

1990 ◽  
Vol 38 (3) ◽  
pp. 761-764 ◽  
Author(s):  
Toshiaki KOIZUMI ◽  
Masamitsu HONMA ◽  
Yasuhiro YAMANE
Keyword(s):  
Acute Toxicity ◽  
Urinary Excretion ◽  
Protective Effect ◽  
Mercuric Chloride ◽  
Sodium Molybdate

Protective effect of sodium molybdate against the acute toxicity of cadmium chloride

Toxicology ◽  
1990 ◽  
Vol 60 (3) ◽  
pp. 235-243 ◽  
Author(s):  
Yasuhiro Yamane ◽  
Mikiko Fukuchi ◽  
Chiko Li ◽  
Toshiaki Koizumi
Keyword(s):  
Acute Toxicity ◽  
Protective Effect ◽  
Cadmium Chloride ◽  
Sodium Molybdate

Increased Urinary Excretion of Carnitine and Acylcarnitine by Mercuric Chloride Is Reversed by 2,3-Dimercapto-1-Propanesulfonic Acid in Rats

2010 ◽  
Vol 29 (3) ◽  
pp. 313-317
Author(s):  
Waleed A. Al-Madani ◽  
Nikhat J. Siddiqi ◽  
Abdullah S. Alhomida ◽  
Haseeb A. Khan ◽  
Ibrahim A. Arif ◽  
...  
Keyword(s):  
Body Weight ◽  
Urinary Excretion ◽  
Mercuric Chloride ◽  
Free Carnitine ◽  
Male Rats ◽  
Significant Protection ◽  
Total Carnitine ◽  
Dose Dependent Increase ◽  
Dose Dependent ◽  
Wistar Male Rats

This investigation was aimed to study the effect of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on mercuric chloride (HgCl2)-induced alterations in urinary excretion of various carnitine fractions including free carnitine (FC), acylcarnitine (AC), and total carnitine (TC). Different groups of Wistar male rats were treated with HgCl2 at the doses of 0.1, 0.5, 1.0, 2.0, and 3.0 mg/kg body weight, and the animals were sacrificed at 24 hours following HgCl2 injection. A separate batch of animals received HgCl2 (2 mg/kg) with or without DMPS (100 mg/kg) and sacrificed at 24 or 48 hours after dosing. Administration of HgCl2 resulted in statistically significant and dose-dependent increase in the urinary excretion of FC, AC, and TC in rats. However, the ratio of urinary AC:FC was significantly decreased by HgCl2. Pretreatment with DMPS offered statistically significant protection against HgCl2-induced alterations in various urinary carnitine fractions in rats.

Protective effect of sulfhydryl compounds on acute toxicity of morphinone

Life Sciences ◽  
1982 ◽  
Vol 30 (13) ◽  
pp. 1121-1127 ◽  
Author(s):  
Kunisuke Nagamatsu ◽  
Yasumasa Kido ◽  
Tadao Terao ◽  
Takashi Ishida ◽  
Satoshi Toki
Keyword(s):  
Acute Toxicity ◽  
Protective Effect ◽  
Sulfhydryl Compounds
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