scholarly journals Studies on Angiotensin Converting Enzyme Inhibitors. VI. Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of the Dicarboxylic Acid Derivative of Imidapril and Its Diastereoisomers.

1992 ◽  
Vol 40 (6) ◽  
pp. 1619-1622 ◽  
Author(s):  
Hitoshi KUBOTA ◽  
Ken-ichi NUNAMI ◽  
Kimiaki HAYASHI ◽  
Yoshikatsu HASHIMOTO ◽  
Noriko OGIKU ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Dicarboxylic Acid ◽  
Acid Derivative ◽  
Enzyme Inhibitors ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
Inhibitory Activities

Synthesis and evaluation of methyl 2-methoxycarbonyl-3-phenylpropionate derivatives as a new type of angiotensin converting enzyme inhibitors

2006 ◽  
Vol 84 (9) ◽  
pp. 1110-1113 ◽  
Author(s):  
Xiao-hua Cai ◽  
Bing Xie ◽  
Hui Guo
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Ace Inhibitor ◽  
Enzyme Inhibitors ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Converting Enzyme ◽  
Key Words Hypertension ◽  
Converting Enzyme Inhibitors ◽  
Control Drug ◽  
New Type ◽  
Inhibitory Activities

Methyl 2-methoxycarbonyl-3-phenylpropionate derivatives were prepared, and their inhibitory activities for angiotensin converting enzyme (ACE) were evaluated. Compounds 5b (IC50 = 0.0039 µmol/L), 5d (IC50 = 0.0027 µmol/L), 5e (IC50 = 0.0021 µmol/L), and5f (IC50 = 0.0052 µmol/L) exhibited more potent ACE inhibitiory activity than the control drug Captopril® (IC50 = 0.0075 µmol/L).Key words: hypertension, 2-methoxycarbonyl-3-phenyl propionate derivative, ACE inhibitor.

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