Comparison Between Lercanidipine and Amlodipine for Efficacy and Tolerability in Patients with Hypertension

Introduction: Hypertension has been perceived as a worldwide health worry for non-industrial nations and is hardly depicted in a considerable lot of these nations. Objectives: The main objective of the study is to find the Comparison between lercanidipine and amlodipine for efficacy and tolerability in patients with hypertension. Material and methods: This cross sectional, comparative study was conducted in PIMS during January 2021 to June 2021. After permission from hospital ethical committee, total 120 patients meeting the inclusion and exclusion criteria will be enrolled in the study from Medical Emergency and admitted in PIMS. Detailed history, physical examination and necessary investigations will be done to meet the inclusion and exclusion criteria. Informed consent will be obtained. Results: The data was collected from 120 patients of both male and female. Table 01 shows the mean values of systolic and diastolic BP according to age and gender. The mean systolic and diastolic BP of all the study subjects were 124.2 ± 15.0 mmHg and 83.4 ± 9.5 mmHg, respectively. In men, the highest mean systolic BP and mean diastolic BP were among the eldest age group and preceding eldest age group. Conclusion: It is concluded that lercanidipine is associated with considerably lower incidence of vasodilation related side effects than amlodipine, especially pedal edema. Key words: Hypertension, Efficacy, Drugs, Therapy

association of Serum Vitamin D levels with Hypertension

Objectives: The objective of our study was to identify the effect of low serum vitamin D levels on hypertension & to make a comparison of levels of vitamin D in hypertensives and healthy individuals. Materials and Method: A cross-sectional comparative study carried out in Cardiology Department of Shaikh Zayed Hospital and Punjab Institute of Cardiology, which involved measurement and comparison of serum Vitamin D levels in 64 subjects, categorized in two groups; hypertensives and normotensives, in order to establish a potential association between vitamin D levels and hypertension. Results: Our study showed that Serum Vitamin D was equally sub-optimal in all participants of study, including both hypertensive group and the healthy controls. As a result of this finding, a clear pattern of association of vitamin D deficiency with hypertension could not be seen. Mean ±SD Vitamin D levels was 19.5±10.0 ng/L in hypertensives and 19.5±13.6 in healthy individuals. This study did not lead to establishment of an association between hypertension and vitamin D levels. Conclusion: Because of deficiency of Vitamin D in general population in this region, our study failed to show an association between Vitamin D and hypertension. Further exploration is needed in this regard. Key words: Hypertension, serum Vitamin D levels

THE USE OF MEDICINES IN TREATING HYPERTENSION IN HUE UNIVERSITY HOSPITAL

Background: Hypertension is a common condition in the world as well as in Viet Nam. If hypertension isn’t treated well, it can cause many serious complications. Controlling target blood pressure will bring positive effects on reducing mortality rate and also disabilities caused by diseases related to hypertension. Objectives: (1) Analyzing the use of medicines in treating hypertension. (2) Evaluating the effects of medicine usage in treating hypertension at the hospital of Hue University of Medicine and Pharmacy. Materials and methods: 388 patients were diagnosed as having hypertension with inpatient care at the Cardiovascular Department of Hue University of Medicine and Pharmacy’s hospital, using cross-sectional descriptive study methods. Results: All antihypertensive drugs in the research were contained in the antihypertensive list recommended by Vietnamese Society of Cardiology. Angiotensin converting enzyme inhibitor and calcium channel blocker were the two most popular drug groups (96.6% and 71.4%, respectively). The rate of using multi-therapy regimens was higher than the rate of using uni-therapy regimens in both initial therapies (64.7%>35.3%) and final therapies (61.9%>38.1%). The rate of patients having interactions between antihypertensive drugs and the other kinds of drugs was 7.5%. The rate of patients having reasonable prescriptions was 84.3%. Evaluating the effects of medicine usage in treatments showed that the rate of patients reaching target blood pressure before leaving the hospital was 67.3%. Most patients were evaluated as having good prognosis after treatment, up to 81.7%. Conclusions: All antihypertensive drugs in the research were contained in the antihypertensive list recommended by Vietnamese Society of Cardiology. The rate of using multi-therapy regimens was higher than the rate of using uni-therapy regimens. The rate of drug interactions was quite low; most patients were evaluated as having good prognosis after treatment. Key words: hypertension, antihypertensive drugs.

Epistaksis dan Hipertensi : Adakah Hubungannya?

Abstrak Latar Belakang: Epistaksis merupakan suatu kondisi klinis yang sering ditemui dan dapat terjadi pada semua umur dengan banyak variasi penyebabnya. Salah satu faktor risiko yang diduga ikut berperan dalam terjadinya epistaksis adalah hipertensi. Tujuan: Menjelaskan hubungan antara epistaksis dengan hipertensi. Tinjauan Pustaka: Hipertensi diduga tidak menyebabkan epistaksis secara langsung, tapi memperberat episode epistaksis. Mengendalikan tekanan darah sebagai salah satu faktor risiko, akan menurunkan insiden terjadinya epistaksis. Di ruang gawat darurat, pemberian obat anti hipertensi diberikan sebelum atau bersamaan dengan manajemen epistaksis itu sendiri. Kesimpulan: Terdapat hubungan antara epistaksis dengan hipertensi yang berlangsung lama dan adanya hipertrofi ventrikel kiri. Kata kunci : Hipertensi, kegawatdaruratan, penatalaksanaan epistaksis. Abstract Background: Epistaxis is a common clinical problem in all age groups with varied etiological factors. Hypertension has been suggested as a risk factor in epistaxis case. Purpose: To explain relationship between epistaxis and hypertension. Review: It has been suggested that hypertension does not cause epistaxis directly, but hypertension prolongs the episode of epistaxis when it does occur. The controlling for blood pressure as a risk factor will be decreased the incidencies of epistaxis. In emergency rooms, high blood pressure is usually treated before or in parallel with the management of epistaxis. Conclusion: There was an association between epistaxis and long duration of hypertension in adult and left ventricle hypertrophy. Key words : Hypertension, emergency case, management of epistaxis.

Antihypertensive therapy in patients with liver diseases. Can we decrease the risk of liver fibrosis by affecting renin-angiotensin system?

The paper summarizes data on antihypertensive treatment in hypertensive patients with concomitant hepatic diseases when inflammation and fibrosis result in liver cytoarchitecture changes. Rennin-angiotensin-aldosterone system blockade enables to reduce tissue damage and fibrosis development regardless of blood pressure decrease. The majority of hypertensive patients requiring combination antihypertensive therapy can benefit in achieving target blood pressure faster, decreasing side effects risk, and in improving liver function. Key words: hypertension, liver diseases, rennin-angiotensin-aldosterone system blockade.

Synthesis and evaluation of methyl 2-methoxycarbonyl-3-phenylpropionate derivatives as a new type of angiotensin converting enzyme inhibitors

Methyl 2-methoxycarbonyl-3-phenylpropionate derivatives were prepared, and their inhibitory activities for angiotensin converting enzyme (ACE) were evaluated. Compounds 5b (IC50 = 0.0039 µmol/L), 5d (IC50 = 0.0027 µmol/L), 5e (IC50 = 0.0021 µmol/L), and5f (IC50 = 0.0052 µmol/L) exhibited more potent ACE inhibitiory activity than the control drug Captopril® (IC50 = 0.0075 µmol/L).Key words: hypertension, 2-methoxycarbonyl-3-phenyl propionate derivative, ACE inhibitor.

Effect of Hypertension in Pregnancy on Birth Weight

Key Words: hypertension; birth weight; low birth weight; pregnancyDOI: 10.3329/jcmcta.v21i2.7732 Journal of Chittagong Medical College Teachers' Association 2010: 21(2):21-24