Synthesis and evaluation of methyl 2-methoxycarbonyl-3-phenylpropionate derivatives as a new type of angiotensin converting enzyme inhibitors
Keyword(s):
New Type
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Methyl 2-methoxycarbonyl-3-phenylpropionate derivatives were prepared, and their inhibitory activities for angiotensin converting enzyme (ACE) were evaluated. Compounds 5b (IC50 = 0.0039 µmol/L), 5d (IC50 = 0.0027 µmol/L), 5e (IC50 = 0.0021 µmol/L), and5f (IC50 = 0.0052 µmol/L) exhibited more potent ACE inhibitiory activity than the control drug Captopril® (IC50 = 0.0075 µmol/L).Key words: hypertension, 2-methoxycarbonyl-3-phenyl propionate derivative, ACE inhibitor.
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