scholarly journals A New Inhibitor of ADAM17 Composed of a Zinc-Binding Dithiol Moiety and a Specificity Pocket-Binding Appendage

2021 ◽  
Vol 69 (11) ◽  
pp. 1123-1130
Author(s):  
Hiroshi Tateishi ◽  
Mika Tateishi ◽  
Mohamed O Radwan ◽  
Takuya Masunaga ◽  
Kosuke Kawatashiro ◽  
...  
Keyword(s):  
Zinc Binding

Stratified Zinc‐Binding Strategy toward Prolonged Cycling and Flexibility of Aqueous Fibrous Zinc Metal Batteries

2021 ◽  
Vol 11 (16) ◽  
pp. 2100214
Author(s):  
Zhaoxi Shen ◽  
Lei Luo ◽  
Chaowei Li ◽  
Jun Pu ◽  
Junpeng Xie ◽  
...  
Keyword(s):  
Zinc Binding ◽  
Zinc Metal

scholarly journals The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Erna Davydova ◽  
Tadahiro Shimazu ◽  
Maren Kirstin Schuhmacher ◽  
Magnus E. Jakobsson ◽  
Hanneke L. D. M. Willemen ◽  
...  
Keyword(s):  
Amino Acid ◽  
Protein Function ◽  
Crucial Role ◽  
Complex I ◽  
Protein Modification ◽  
Zinc Binding ◽  
Functional Studies ◽  
Mitochondrial Respiratory Complex ◽  
Respiratory Complex I ◽  
Broad Specificity

AbstractPost-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first reported five decades ago, but remains largely unexplored. Here we report that METTL9 is a broad-specificity methyltransferase that mediates the formation of the majority of 1MH present in mouse and human proteomes. METTL9-catalyzed methylation requires a His-x-His (HxH) motif, where “x” is preferably a small amino acid, allowing METTL9 to methylate a number of HxH-containing proteins, including the immunomodulatory protein S100A9 and the NDUFB3 subunit of mitochondrial respiratory Complex I. Notably, METTL9-mediated methylation enhances respiration via Complex I, and the presence of 1MH in an HxH-containing peptide reduced its zinc binding affinity. Our results establish METTL9-mediated 1MH as a pervasive protein modification, thus setting the stage for further functional studies on protein histidine methylation.

scholarly journals Novel zinc-binding center and a temperature switch in the Bacillus stearothermophilus L1 lipase.

2002 ◽  
Vol 277 (28) ◽  
pp. 25840
Author(s):  
Seong-Tae Jeong ◽  
Hyung-Kwoun Kim ◽  
Seung-Jun Kim ◽  
Seung-Wook Chi ◽  
Jae-Gu Pan ◽  
...  
Keyword(s):  
Bacillus Stearothermophilus ◽  
Zinc Binding ◽  
Binding Center ◽  
Temperature Switch

Ecl1 is a zinc-binding protein involved in the zinc-limitation-dependent extension of chronological life span in fission yeast

2017 ◽  
Vol 292 (2) ◽  
pp. 475-481 ◽  
Author(s):  
Takafumi Shimasaki ◽  
Hokuto Ohtsuka ◽  
Chikako Naito ◽  
Kenko Azuma ◽  
Takeshi Tenno ◽  
...  
Keyword(s):  
Life Span ◽  
Fission Yeast ◽  
Binding Protein ◽  
Zinc Binding ◽  
Chronological Life Span

scholarly journals Implications on zinc binding to S100A2

2007 ◽  
Vol 1773 (3) ◽  
pp. 457-470 ◽  
Author(s):  
Michael Koch ◽  
Shibani Bhattacharya ◽  
Torsten Kehl ◽  
Mario Gimona ◽  
Milan Vašák ◽  
...  
Keyword(s):  
Zinc Binding

scholarly journals Biochemical characterization and zinc binding group (ZBGs) inhibition studies on the catalytic domain of MMP7 (cdMMP7)

2016 ◽  
Vol 165 ◽  
pp. 7-17 ◽  
Author(s):  
Fan Meng ◽  
Hao Yang ◽  
Colin Jack ◽  
Huaqun Zhang ◽  
Abraham Moller ◽  
...  
Keyword(s):  
Biochemical Characterization ◽  
Catalytic Domain ◽  
Zinc Binding ◽  
Inhibition Studies
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