Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico–in vivo extrapolation and physiologically-based pharmacokinetic modeling approach

Physiologically Based ◽

In Vivo Extrapolation ◽

Oral Prodrug

CYP2B6 Pharmacogenetics–Based In Vitro–In Vivo Extrapolation of Efavirenz Clearance by Physiologically Based Pharmacokinetic Modeling

Drug Metabolism and Disposition ◽

10.1124/dmd.113.051755 ◽

2013 ◽

Vol 41 (12) ◽

pp. 2004-2011 ◽

Cited By ~ 19

Author(s):

Cong Xu ◽

Sara K. Quinney ◽

Yingying Guo ◽

Stephen D. Hall ◽

Lang Li ◽

...

Keyword(s):

Physiologically Based ◽

Computational Predictions of Mycophenolic Acid Exposure after Oral Administration using a Joined In Vitro–In Vivo Extrapolation and Physiologically-Based Pharmacokinetic Modeling Approach in Caucasian and Chinese Healthy Volunteers and Patients With Varying Degree of Renal Impairment

Transplantation Journal ◽

10.1097/01.tp.0000520312.63960.a6 ◽

2017 ◽

Vol 101 ◽

pp. S13-S14 ◽

Cited By ~ 1

Author(s):

Rujuta Joshi ◽

Raman Venkataramanan ◽

Hari Varun Kalluri

Keyword(s):

Renal Impairment ◽

Oral Administration ◽

Mycophenolic Acid ◽

Physiologically Based ◽

In Vivo Extrapolation ◽

Computational Predictions

Addressing Early Life Sensitivity Using Physiologically Based Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation

Toxicological Research ◽

10.5487/tr.2016.32.1.015 ◽

2016 ◽

Vol 32 (1) ◽

pp. 15-20 ◽

Cited By ~ 11

Author(s):

Miyoung Yoon ◽

Harvey J. Clewell

Keyword(s):

Early Life ◽

Physiologically Based ◽

Using physiologically based pharmacokinetic modelling for in silico–in vitro–in vivo extrapolation to predict chemical exposure

Toxicology Letters ◽

10.1016/j.toxlet.2016.06.1484 ◽

2016 ◽

Vol 258 ◽

pp. S119-S120

Author(s):

M. Lawless ◽

H. Zhou ◽

G. Fraczkiewicz

Keyword(s):

In Silico ◽

Chemical Exposure ◽

Pharmacokinetic Modelling ◽

Physiologically Based Pharmacokinetic Modelling ◽

Physiologically Based ◽

In Vitro to In Vivo Extrapolation of Metabolic Rate Constants for Physiologically Based Pharmacokinetic Models

Toxicokinetics and Risk Assessment ◽

10.1201/b14275-9 ◽

2016 ◽

pp. 185-210

Author(s):

Gregory L. Kedderis

Keyword(s):

Metabolic Rate ◽

Rate Constants ◽

Pharmacokinetic Models ◽

Physiologically Based Pharmacokinetic Models ◽

Physiologically Based ◽

In vitro-in silico-based probabilistic risk assessment of combined exposure to bisphenol A and its analogues by integrating ToxCast high-throughput in vitro assays with in vitro to in vivo extrapolation (IVIVE) via physiologically based pharmacokinetic (PBPK) modeling

Journal of Hazardous Materials ◽

10.1016/j.jhazmat.2020.122856 ◽

2020 ◽

Vol 399 ◽

pp. 122856

Author(s):

Yi-Jun Lin ◽

Zhoumeng Lin

Keyword(s):

Risk Assessment ◽

Bisphenol A ◽

Pbpk Modeling ◽

In Vitro Assays ◽

Combined Exposure ◽

Physiologically Based ◽

Physiologically Based Pharmacokinetic Modeling of Benzene Metabolism in Mice Through Extrapolation from In Vitro to In Vivo

Journal of Toxicology and Environmental Health Part A ◽

10.1080/00984100150501178 ◽

2001 ◽

Vol 62 (6) ◽

pp. 439-465 ◽

Cited By ~ 18

Author(s):

Cammey E. Cole ◽

Hien T. Tran ◽

Paul M. Schlosser

Keyword(s):

Physiologically Based

Physiologically Based Pharmacokinetic (PBPK) Modelling for In Vitro-In Vivo Extrapolation: Emphasis on the Use of Dissolution Data

Dissolution Technologies ◽

10.14227/dt260319p18 ◽

2019 ◽

Vol 26 (3) ◽

pp. 18-27

Author(s):

Vivek M. Ghate ◽

Pinal Chaudhari ◽

Shaila A. Lewis

Keyword(s):

Pbpk Modelling ◽

Physiologically Based ◽

Evaluation of Age-Related Pyrethroid Pharmacokinetic Differences in Rats: Physiologically-Based Pharmacokinetic Model Development Using In Vitro Data and In Vitro to In Vivo Extrapolation

Toxicological Sciences ◽

10.1093/toxsci/kfz042 ◽

2019 ◽

Vol 169 (2) ◽

pp. 365-379 ◽

Cited By ~ 9

Author(s):

Gina Song ◽

Marjory Moreau ◽

Alina Efremenko ◽

Brian G Lake ◽

Huali Wu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Model Development ◽

Age Related ◽

Physiologically Based ◽

In Vivo Extrapolation ◽

Vitro Data ◽

In Vitro Data

Blood Concentrations of 1,4-Dioxane in Humans after Oral Administration Extrapolated from In Vivo Rat Pharmacokinetics, In Vitro Human Metabolism, and Physiologically Based Pharmacokinetic Modeling

JOURNAL OF HEALTH SCIENCE ◽

10.1248/jhs.56.557 ◽

2010 ◽

Vol 56 (5) ◽

pp. 557-565 ◽

Cited By ~ 7

Author(s):

Ryohji Takano ◽

Norie Murayama ◽

Kana Horiuchi ◽

Masato Kitajima ◽

Fumiaki Shono ◽

...

Keyword(s):

Oral Administration ◽

Human Metabolism ◽

Blood Concentrations ◽

Physiologically Based