Contribution of endothelium-derived nitric oxide (EDNO) to the skeletal muscle blood flow response to exercise

1995 ◽  
Vol 27 (8) ◽  
pp. 1145???1151 ◽  
Author(s):  
RICHARD M. MCALLISTER ◽  
TADAKAZU HIRAI ◽  
TIMOTHY I. MUSCH
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Blood Flow ◽  
Muscle Blood Flow ◽  
Skeletal Muscle Blood Flow ◽  
Blood Flow Response ◽  
Flow Response ◽  
Response To Exercise

Biphasic effect of hydrogen peroxide on skeletal muscle arteriolar tone via activation of endothelial and smooth muscle signaling pathways

2004 ◽  
Vol 97 (3) ◽  
pp. 1130-1137 ◽  
Author(s):  
Csongor Csekő ◽  
Zsolt Bagi ◽  
Akos Koller
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Hydrogen Peroxide ◽  
Blood Flow ◽  
Smooth Muscle ◽  
Muscle Blood Flow ◽  
Skeletal Muscle Blood Flow ◽  
Local Regulation ◽  
Prostaglandin H ◽  
Arteriolar Tone

We hypothesized that hydrogen peroxide (H2O2) has a role in the local regulation of skeletal muscle blood flow, thus significantly affecting the myogenic tone of arterioles. In our study, we investigated the effects of exogenous H2O2 on the diameter of isolated, pressurized (at 80 mmHg) rat gracilis skeletal muscle arterioles (diameter of ∼150 μm). Lower concentrations of H2O2 (10−6–3 × 10−5 M) elicited constrictions, whereas higher concentrations of H2O2 (6 × 10−5–3 × 10−4 M), after initial constrictions, caused dilations of arterioles (at 10−4 M H2O2, −19 ± 1% constriction and 66 ± 4% dilation). Endothelium removal reduced both constrictions (to −10 ± 1%) and dilations (to 33 ± 3%) due to H2O2. Constrictions due to H2O2 were completely abolished by indomethacin and the prostaglandin H2/thromboxane A2 (PGH2/TxA2) receptor antagonist SQ-29548. Dilations due to H2O2 were significantly reduced by inhibition of nitric oxide synthase (to 38 ± 7%) but were unaffected by clotrimazole or sulfaphenazole (inhibitors of cytochrome P-450 enzymes), indomethacin, or SQ-29548. In endothelium-denuded arterioles, clotrimazole had no effect, whereas H2O2-induced dilations were significantly reduced by charybdotoxin plus apamin, inhibitors of Ca2+-activated K+ channels (to 24 ± 3%), the selective blocker of ATP-sensitive K+ channels glybenclamide (to 14 ± 2%), and the nonselective K+-channel inhibitor tetrabutylammonium (to −1 ± 1%). Thus exogenous administration of H2O2 elicits 1) release of PGH2/TxA2 from both endothelium and smooth muscle, 2) release of nitric oxide from the endothelium, and 3) activation of K+ channels, such as Ca2+-activated and ATP-sensitive K+ channels in the smooth muscle resulting in biphasic changes of arteriolar diameter. Because H2O2 at low micromolar concentrations activates several intrinsic mechanisms, we suggest that H2O2 contributes to the local regulation of skeletal muscle blood flow in various physiological and pathophysiological conditions.

scholarly journals Correction to: The skin blood flow response to exercise in boys and men and the role of nitric oxide

2020 ◽  
Vol 120 (4) ◽  
pp. 763-764
Author(s):  
Alexandra Woloschuk ◽  
Gary J. Hodges ◽  
Raffaele J. Massarotto ◽  
Panagiota Klentrou ◽  
Bareket Falk
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Skin Blood Flow ◽  
Blood Flow Response ◽  
Flow Response ◽  
Response To Exercise

The skin blood flow response to exercise in boys and men and the role of nitric oxide

2019 ◽  
Vol 120 (4) ◽  
pp. 753-762 ◽  
Author(s):  
Alexandra Woloschuk ◽  
Gary J. Hodges ◽  
Raffaele J. Massarotto ◽  
Panagiota Klentrou ◽  
Bareket Falk
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Skin Blood Flow ◽  
Blood Flow Response ◽  
Flow Response ◽  
Response To Exercise

scholarly journals Combined inhibition of nitric oxide and prostaglandins reduces human skeletal muscle blood flow during exercise

2002 ◽  
Vol 543 (2) ◽  
pp. 691-698 ◽  
Author(s):  
Robert Boushel ◽  
Henning Langberg ◽  
Carsten Gemmer ◽  
Jens Olesen ◽  
Regina Crameri ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Skeletal Muscle ◽  
Blood Flow ◽  
Human Skeletal Muscle ◽  
Muscle Blood Flow ◽  
Skeletal Muscle Blood Flow
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