Temporal Sequential Pattern of Right Ventricular Free Wall Contraction in Normal Children

Routine clinical right ventricular pacing generates left ventricular dyssynchrony manifested by early septal shortening followed by late lateral contraction, which, in turn, reciprocally stretches the septum. Dyssynchrony is disadvantageous to cardiac mechanoenergetics and worsens clinical prognosis, yet little is known about its molecular consequences. Here, we report the influence of cardiac dyssynchrony on regional cardiac gene expression in mice. Mice were implanted with a custom-designed miniature cardiac pacemaker and subjected to 1-wk overdrive right ventricular free wall pacing (720 beats/min, baseline heart rate 520–620 beats/min) to generate dyssynchrony (pacemaker: 3-V lithium battery, rate programmable, 1.5 g, bipolar lead). Electrical capture was confirmed by pulsed-wave Doppler and dyssynchrony by echocardiography. Gene expression from the left ventricular septal and lateral wall myocardium was assessed by microarray (dual-dye method, Agilent) using oligonucleotide probes and dye swap. Identical analysis was applied to four synchronously contracting controls. Of the 22,000 genes surveyed, only 18 genes displayed significant ( P < 0.01) differential expression between septal/lateral walls >1.5 times that in synchronous controls. Gene changes were confirmed by quantitative PCR with excellent correlations. Most of the genes ( n = 16) showed greater septal expression. Of particular interest were seven genes coding proteins involved with stretch responses, matrix remodeling, stem cell differentiation to myocyte lineage, and Purkinje fiber differentiation. One week of iatrogenic cardiac dyssynchrony triggered regional differential expression in relatively few select genes. Such analysis using a murine implantable pacemaker should facilitate molecular studies of cardiac dyssynchrony and help elucidate novel mechanisms by which stress/stretch stimuli due to dyssynchrony impact the normal and failing heart.

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Correction to: Preoperative Right Ventricular Free‐Wall Longitudinal Strain as a Prognosticator in Isolated Surgery for Severe Functional Tricuspid Regurgitation

Journal of the American Heart Association ◽

10.1161/jaha.121.020842 ◽

2021 ◽

Keyword(s):

Right Ventricular ◽

Tricuspid Regurgitation ◽

Longitudinal Strain ◽

Ventricular Free Wall ◽

Free Wall ◽

Right Ventricular Free Wall ◽

Functional Tricuspid Regurgitation

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THE PROGNOSTIC VALUE OF RIGHT VENTRICULAR FREE WALL STRAIN AFTER LUNG TRANSPLANTATION IN PATIENTS WITH SCLERODERMA

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(18)32496-3 ◽

2018 ◽

Vol 71 (11) ◽

pp. A1955

Author(s):

Yuko Soyama ◽

Marc Simon ◽

Masataka Sugahara ◽

Akiko Goda ◽

Nobuyuki Kagiyama ◽

...

Keyword(s):

Lung Transplantation ◽

Right Ventricular ◽

Prognostic Value ◽

Ventricular Free Wall ◽

Free Wall ◽

Right Ventricular Free Wall

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Association of epicardial fat thickness with left ventricular diastolic function parameters in a community population

10.21203/rs.3.rs-171598/v2 ◽

2021 ◽

Author(s):

Wei Ma ◽

Baowei Zhang ◽

Ying Yang ◽

Litong Qi ◽

Jin Zhou ◽

...

Keyword(s):

Confidence Interval ◽

Right Ventricular ◽

Diastolic Function ◽

Ventricular Free Wall ◽

Free Wall ◽

Right Ventricular Free Wall ◽

Community Population ◽

The Mean ◽

The Right ◽

The Relationship

Abstract Purpose We examined the relationship between EFT measured by echocardiography and LV diastolic function parameters in a Beijing community population. Methods We included 1004 participants in this study. Echocardiographic parameters including E and A peak velocity, the early diastolic velocities (e’) of the septal and lateral of mitral annulus using tissue doppler imaging, E/e’, and EFT, were measured. EFT1 was measured perpendicularly on the right ventricular free wall at end-diastole in the extension line of the aortic root. EFT2 was the maximum thickness measured perpendicularly on the right ventricular free wall at end-diastole. Multivariate linear regression was used to analyze the relationship between EFT and the mean e’ and E/e’. Results The mean age of the participants was 63.91 ± 9.02 years old (51.4% men). EFT1 and EFT2 were negatively correlated with e’ lat, e’ sep, and e’ mean (p < 0.05), and positively correlated with E/e’ lat, E/e’ sep, and E/e’ mean. Multivariate regression analysis showed that EFT1 and EFT2 were independently and negatively correlated with e’ mean (EFT1: β = −0.089 [95% confidence interval = − 0.177, − 0.000, p = 0.050]; EFT2: β = −0.078 [95% confidence interval = − 0.143, − 0.012, p = 0.020]). There were no interactions between EFT and any covariates, including age or heart groups, sex, BMI, or presence of hypertension, diabetes, or coronary heart disease in relation to LV diastolic dysfunction. Conclusions EFT was negatively and independently correlated with e’ mean, suggesting that more attention to this type of adipose fat is required for cardiovascular disease therapy.

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Progressive right ventricular outflow tract fibrosis after repair of tetralogy of Fallot

Cardiology in the Young ◽

10.1017/s1047951120002164 ◽

2020 ◽

Vol 30 (9) ◽

pp. 1366-1367

Author(s):

Gauri R. Karur ◽

Wadi Mawad ◽

Lars Grosse-Wortmann

Keyword(s):

Cardiac Magnetic Resonance ◽

Right Ventricular ◽

Tetralogy Of Fallot ◽

T1 Mapping ◽

Right Ventricular Outflow Tract ◽

Ventricular Outflow Tract ◽

Ventricular Free Wall ◽

Free Wall ◽

Right Ventricular Free Wall ◽

The Right

AbstractObjectives:The objective of this study was to determine the evolution of fibrosis over time and its association with clinical status.Methods:Children with repaired tetralogy of Fallot who had undergone at least two cardiac magnetic resonance examinations including T1 mapping at least 1 year apart were included.Results:Thirty-seven patients (12.7 ± 2.6 years, 61% male) were included. Right ventricular free wall T1 increased (913 ± 208 versus 1023 ± 220 ms; p = 0.02). Baseline cardiac magnetic resonance parameters did not predict a change in imaging markers or exercise tolerance. The right ventricular free wall per cent change correlated with left ventricular T1% change (r = 0.51, p = 0.001) and right ventricular mass Z-score change (r = 0.51, p = 0.001). T1 in patients with late gadolinium enhancement did not differ from the rest.Conclusion:Increasing right ventricular free wall T1 indicates possible progressive fibrotic remodelling in the right ventricular outflow tract in this pilot study in children and adolescents with repaired tetralogy of Fallot. The value of T1 mapping both at baseline and during serial assessments will need to be investigated in larger cohorts with longer follow-up.

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P925 An analysis of the impact of etiology vs. impact of hemodynamic variables on the right ventricular free wall deformation in patients with pulmonary hypertension

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jez319.560 ◽

2020 ◽

Vol 21 (Supplement_1) ◽

Author(s):

N Ojrzynska ◽

E Kowalik ◽

M Kowalski ◽

A Klisiewicz ◽

M Demkow ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Right Ventricular ◽

Ventricular Free Wall ◽

P Value ◽

Free Wall ◽

Right Ventricular Free Wall ◽

Mean Pulmonary Arterial Pressure ◽

Hemodynamic Variables ◽

Cardiac Catherization ◽

The Impact

Abstract Purpose Pulmonary hypertension (PH) is a deadly disease leading to right ventricular (RV) failure. The aim of this study was to establish whether aetiology of PH has a greater impact on RV longitudinal deformation than cardiac catherization parameters. Methods We retrospectively analyzed echocardiographic studies and cardiac catherization parameters of 25 patients with pulmonary hypertension : 13 pts with precapillary PH associated with atrial/ventricular septum defect and 12 pts with postcapillary PH due to dilated cardiomyopathy. We measured regional strain and regional systolic and diastolic strain rates (SR) in right ventricular free wall in basal, mid and apical segments. Results Aside from TAPSE, echocardiographic parameters indicate no difference. Even though mean pulmonary arterial pressure and pulmonary vascular residence significantly higher in patients with precapillary PH, strain was significantly decreased in patients with postcapillary PH. Statistically significant differences were observed between pre- and postcapillary PH patients" strain in apical and mid myocardial segments. Early diastolic strain rate (SR) in apical RV segment in precapillary PH patients was significantly higher than in patients with postcapillary PH. In other myocardial segments there were no differences between systolic, early diastolic and late diastolic SR. Conclusion Our study suggests that RV free wall strain in patients with PH moderately correlate with aetiology of PH. We did not find correlation between higher RA pressure or PVR and worsening of RV function in PH of different aetiologies. Precapillary PH Postcapillary PH p value PA mean pressure (mmHG) 75,2 ± 17,7 42,0 ± 7,3 <0,05 PWR (WU) 15,8 ± 6,7 4,7 ± 2,6 <0,05 RV wall thickenss (mm) 11,0 ± 2,5 5,5 ± 1,0 NS RVIT (mm) 42,7 ± 10,4 42,8 ± 8,1 NS TAPSE (mm) 19,2 ± 4,2 15,6 ± 4,9 <0,05 S" 10,8 ± 2,0 9,4 ± 2,1 NS basal segment strain -16 ± 7 -17 ± 5 NS mid segment strain -18 ± 8 -15 ± 4 <0,05 apical segment strain -19 ± 8 -14 ± 4 <0,05

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