The "Pressor Reflex" of Bladder Origin : STUDY OF A CASE WITH HYPERACTIVE "PRESSOR REFLEX" OF BLADDER ORIGIN, BILATERAL HYDRONEPHROSIS POSSIBLY COMPLICATED WITH PYELONEPHRITIS, AND THE STRICTURE OF THE URETHRA

The purpose of this study was to examine differences in pressor response and cardiovagal modulation during isometric handgrip exercise (IHG) between children and adults. Beat-to-beat heart rate (HR) and blood pressure were measured in 23 prepubertal children and 23 adults at baseline and during IHG. Cardiovagal modulation was quantified by analysis of HR variability. Mean arterial pressure responses to IHG were greater in adults compared to children (P<.05) whereas there were no group differences in HR responses (P>.05). Children had a greater reduction in cardiovagal modulation in response to IHG compared to adults (P<.05). Changes in mean arterial pressure during IHG were correlated with baseline cardiovagal modulation and force produced during isometric contraction (P<.05). In conclusion, differences in pressor reflex response between children and adults cannot be solely explained by differences in autonomic modulation and appear to be associated with factors contributing to the force produced during isometric contraction.

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Mechanoreflex Mediates the Exaggerated Exercise Pressor Reflex in Heart Failure

Circulation ◽

10.1161/circulationaha.105.566745 ◽

2005 ◽

Vol 112 (15) ◽

pp. 2293-2300 ◽

Cited By ~ 78

Author(s):

Scott A. Smith ◽

Jere H. Mitchell ◽

R. Haris Naseem ◽

Mary G. Garry

Keyword(s):

Heart Failure ◽

Exercise Pressor Reflex ◽

Pressor Reflex

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Palliative radiation treatment used for multiple purposes in a single irradiation field

BMJ Case Reports ◽

10.1136/bcr-2021-244172 ◽

2021 ◽

Vol 14 (9) ◽

pp. e244172

Author(s):

Kosei Miura ◽

Hiromasa Kurosaki ◽

Nobuko Utsumi

Keyword(s):

Creatinine Level ◽

Radiation Treatment ◽

Peritoneal Dissemination ◽

Spine Metastasis ◽

Palliative Radiation ◽

Bilateral Hydronephrosis ◽

Gastrointestinal Obstruction ◽

Irradiation Therapy ◽

Irradiation Field ◽

Multiple Bone Metastases

In this case report, radiation therapy was performed for bilateral hydronephrosis developed during multiple bone metastases of breast cancer and ileus due to peritoneal dissemination. The patient’s preirradiation creatinine level was 8.2 mg/dL, which decreased by the fourth day after starting irradiation therapy. Creatinine level ultimately decreased to 0.6 mg/dL. Pain due to lumbar spine metastasis alleviated and ileus was resolved, allowing the patient to live at home for approximately 5 weeks. The effect of radiotherapy for bilateral hydronephrosis and gastrointestinal obstruction was rapid and good. Palliative radiation treatment can be used for multiple purposes, and in the present patient, we were able to prolong the vital prognosis.

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Congenital Nephrogenic Diabetes Insipidus Presented with Bilateral Hydronephrosis: Genetic Analysis of V2R Gene Mutations

Yonsei Medical Journal ◽

10.3349/ymj.2006.47.1.126 ◽

2006 ◽

Vol 47 (1) ◽

pp. 126 ◽

Cited By ~ 11

Author(s):

Tae-Hyun Yoo ◽

Dong-Ryeol Ryu ◽

Young Soo Song ◽

Sang Chul Lee ◽

Hyung Jong Kim ◽

...

Keyword(s):

Genetic Analysis ◽

Diabetes Insipidus ◽

Nephrogenic Diabetes Insipidus ◽

Gene Mutations ◽

Bilateral Hydronephrosis ◽

Congenital Nephrogenic Diabetes Insipidus

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Effect of electroacupuncture on pressor reflex during gastric distension

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00192.2002 ◽

2002 ◽

Vol 283 (6) ◽

pp. R1335-R1345 ◽

Cited By ~ 48

Author(s):

Peng Li ◽

Kasra Rowshan ◽

Melissa Crisostomo ◽

Stephanie C. Tjen-A-Looi ◽

John C. Longhurst

Keyword(s):

Peroneal Nerve ◽

Cardiovascular Response ◽

Pressor Response ◽

Gastric Wall ◽

Ventrolateral Medulla ◽

Gastric Distension ◽

Sprague Dawley ◽

Sprague Dawley Rats ◽

Stomach Meridian ◽

Pressor Reflex

The effect of electroacupuncture (EA) on the reflex cardiovascular response induced by mechanical distension of the stomach was studied in ventilated male Sprague-Dawley rats anesthetized by ketamine and α-chloralose. Repeated balloon inflation of the stomach to produce 20 mmHg tension on the gastric wall induced a consistent rise in mean arterial pressure, while heart rate (372 ± 22 beats/min) was unchanged. This response was reversed by transection of the splanchnic nerves. Bilateral application of EA (1–2 mA, 2 Hz) at Neiguan-Jianshi acupoints (pericardial meridian, Pe 5–6) over the median nerve for 30 min significantly decreased the pressor response from 33 ± 6 to 18 ± 4 mmHg ( n = 7, P < 0.05). This effect began after 10 min of EA and continued for 40 min after termination of EA. EA at Zusanli-Shangquxu acupoints (stomach meridian, St 36–37) over the deep peroneal nerve similarly inhibited the pressor response. The effect lasted for 10 min after EA was stopped ( n = 6, P < 0.05), while EA at Guangming-Xuanzhong acupoints (gallbladder meridian, GB 37–39) over the superficial peroneal nerve did not inhibit the pressor response. Naloxone injected intravenously ( n = 6) immediately after termination of EA or administered by microinjection into the rostral ventrolateral medulla (rVLM) 25 min after initiation of EA ( n = 6) reversed the inhibition by EA, suggesting an opiate mechanism, including the rVLM, was involved.

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Chronic femoral artery ligation exaggerates the pressor and sympathetic nerve responses during dynamic skeletal muscle stretch in decerebrate rats

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.00498.2017 ◽

2018 ◽

Vol 314 (2) ◽

pp. H246-H254 ◽

Cited By ~ 6

Author(s):

Evan A. Kempf ◽

Korynne S. Rollins ◽

Tyler D. Hopkins ◽

Alec L. Butenas ◽

Joseph M. Santin ◽

...

Keyword(s):

Blood Pressure ◽

Peripheral Artery Disease ◽

Sympathetic Nerve ◽

Sympathetic Nerve Activity ◽

Peripheral Artery ◽

Nerve Activity ◽

Exercise Pressor Reflex ◽

Pressor Reflex ◽

Artery Disease ◽

Dynamic Stretch

Mechanical and metabolic signals arising during skeletal muscle contraction reflexly increase sympathetic nerve activity and blood pressure (i.e., the exercise pressor reflex). In a rat model of simulated peripheral artery disease in which a femoral artery is chronically (~72 h) ligated, the mechanically sensitive component of the exercise pressor reflex during 1-Hz dynamic contraction is exaggerated compared with that found in normal rats. Whether this is due to an enhanced acute sensitization of mechanoreceptors by metabolites produced during contraction or involves a chronic sensitization of mechanoreceptors is unknown. To investigate this issue, in decerebrate, unanesthetized rats, we tested the hypothesis that the increases in mean arterial blood pressure and renal sympathetic nerve activity during 1-Hz dynamic stretch are larger when evoked from a previously “ligated” hindlimb compared with those evoked from the contralateral “freely perfused” hindlimb. Dynamic stretch provided a mechanical stimulus in the absence of contraction-induced metabolite production that closely replicated the pattern of the mechanical stimulus present during dynamic contraction. We found that the increases in mean arterial blood pressure (freely perfused: 14 ± 1 and ligated: 23 ± 3 mmHg, P = 0.02) and renal sympathetic nerve activity were significantly greater during dynamic stretch of the ligated hindlimb compared with the increases during dynamic stretch of the freely perfused hindlimb. These findings suggest that the exaggerated mechanically sensitive component of the exercise pressor reflex found during dynamic muscle contraction in this rat model of simulated peripheral artery disease involves a chronic sensitizing effect of ligation on muscle mechanoreceptors and cannot be attributed solely to acute contraction-induced metabolite sensitization. NEW & NOTEWORTHY We found that the pressor and sympathetic nerve responses during dynamic stretch were exaggerated in rats with a ligated femoral artery (a model of peripheral artery disease). Our findings provide mechanistic insights into the exaggerated exercise pressor reflex in this model and may have important implications for peripheral artery disease patients.

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