scholarly journals Implication of Peroxisome Proliferator-Activated Receptor γ and Proinflammatory Cytokines in Gastric Carcinogenesis: Link to Helicobacter pylori-Infection

2004 ◽  
Vol 96 (2) ◽  
pp. 134-143 ◽  
Author(s):  
Peter C. Konturek ◽  
Joanna Kania ◽  
Vitaly Kukharsky ◽  
Martin Raithel ◽  
Mathias Ocker ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Proinflammatory Cytokines ◽  
Gastric Carcinogenesis ◽  
Helicobacter Pylori Infection ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor

scholarly journals The Role of PPARγinHelicobacter pyloriInfection and Gastric Carcinogenesis

PPAR Research ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Jong-Min Lee ◽  
Sung Soo Kim ◽  
Young-Seok Cho
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Current Knowledge ◽  
Mucosal Injury ◽  
Gastric Carcinogenesis ◽  
Etiologic Factor ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
H Pylori

Peroxisome proliferator-activated receptorγ(PPARγ) is a nuclear receptor that is important in many physiological and pathological processes, such as lipid metabolism, insulin sensitivity, inflammation, cell proliferation, and carcinogenesis. Several studies have shown that PPARγplays an important role in gastric mucosal injury due toHelicobacter pylori(H. pylori). AsH. pyloriinfection is the main etiologic factor in chronic gastritis and gastric cancer, understanding of the potential roles of PPARγinH. pyloriinfection may lead to the development of a therapeutic target. In this paper, the authors discuss the current knowledge on the role of PPARγinH. pyloriinfection and its related gastric carcinogenesis.

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