scholarly journals Irving B. Kravis: Memoir of a Distinguished Fellow

1993 ◽  
Vol 7 (3) ◽  
pp. 175-184 ◽  
Author(s):  
Lawrence R Klein
Keyword(s):  
New Orleans ◽  
University Of Pennsylvania ◽  
American Economic Association ◽  
Distinguished Career ◽  
Economic Association ◽  
The University ◽  
To Receive

The nomination of Irving Kravis as a Distinguished Fellow of the American Economic Association in 1991 crowned a long and distinguished career. He would go on to no further accomplishments, for it was on the trip to the ASSA meetings in New Orleans to receive the award that he passed away at Philadelphia Airport on January 2, 1992. In spite of a debilitating illness, he had continued working until the end on problems and issues that were his main concerns for more than 50 years; with fuller physical powers, he would undoubtedly have made additional contributions to our profession. This paper first discusses his administrative and pedagogical contributions at the University of Pennsylvania and then his notable research contributions.

scholarly journals PATH-25. EXPERIENCE WITH AN RNA FUSION TRANSCRIPT PANEL FOR DETECTION OF POTENTIAL THERAPEUTIC TARGETS IN GLIOMAS

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii169-ii169
Author(s):  
Shawn Kothari ◽  
Stephen Bagley ◽  
Arati Desai ◽  
Jennifer Morrisette ◽  
Robyn Sussman ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Therapeutic Targets ◽  
Fusion Transcript ◽  
Adult Patients ◽  
University Of Pennsylvania ◽  
Lower Grade ◽  
Prospective Trials ◽  
Fusion Analysis ◽  
The University ◽  
To Receive

Abstract Next-generation sequencing to identify fusion proteins is increasingly employed across oncology to identify therapeutic targets.1 The clinical relevance of detecting fusion transcripts is well described in the pediatric glioma population, but similar reports for adult patients are scant.2 The University of Pennsylvania Health System (UPHS) has implemented routine use of an RNA fusion transcript panel (ArcherDX, Boulder, CO) on resected brain tumors since August 2017. Here we report the results of this analysis for adult patients with gliomas and highlight potentially targetable fusions. Over the period of August 2017 through December 2019, fusion analysis was performed on resected gliomas of over 200 patients. Ninety-seven patients were found to have a detected fusion protein. Eighty-three of the 97 patients (86%) had glioblastoma and 14 (14%) had lower grade gliomas. A total of 26 unique fusions were found. The most common (n=55) was EGFRvIII. NTRK fusions were of special interest as FDA-approved agents are available for patients harboring this genetic alteration.3 We identified 8 patients (8%) with NTRK fusions including ARHGEFF2:NTRK1, BNA: NTRK1, BCR: NTRK2, PDE5A/NTRK2, SKAP2/NTRK2, and STRN: NTRK2. Several of these patients went on to receive TRK kinase inhibitors with clinical benefit. Of the 97 patients with a detected fusion, 24 (25%) were found to have a potentially targetable fusion other than EGFRvIII, with inhibitors available in clinical trials or as off-label therapy. These fusions included BRAF (n=5; BRAF: LHFPL3, KIAA1549:BRAF), FGFR (n=9; FGFR3:BRAP, FGFR3:RENBP, FGFR3:TACC3), MET (n=7; CAPZA2-MET, KLF12:MET, PTPRZ1:MET, ST7:MET), and ROS1 (n=3; DLL: ROS1, GOPC: ROS1). In sum, routine clinical use of an RNA-based fusion transcript panel for adult patients with glioma may allow for detection of therapeutically targetable alterations in a meaningful proportion of cases. Prospective trials are needed to determine whether targeting specific fusions is beneficial for adult patients with glioma.

The Early Patinkin—Friedman Correspondence

1998 ◽  
Vol 20 (4) ◽  
pp. 433-448 ◽  
Author(s):  
Robert Leeson
Keyword(s):  
Oral Tradition ◽  
American Economic Association ◽  
Quantity Theory ◽  
Economic Association ◽  
The University

Don Patinkin (1922-95) was a co-author of the Keynesian neoclassical synthesis, and became engaged in several important controversies. One of them involved Milton Friedman's (1956) assertion about a supposed Chicago quantity theory “oral tradition.” From 1968 until his death, Patinkin hardly seemed to miss an opportunity of denigrating what he regarded as Friedman's “invention.” This controversy was taken to the 1970 American Economic Association (AEA) meeting by Harry Johnson (1971), and divided at least two economics departments, Chicago and the University of Western Ontario, where Patinkin and Johnson were frequent visitors, and where two influential monetarists, David Laidler and Michael Parkin, had migrated from Britain (Parkin, 1986; Patinkin, 1986).

John Edgar Wideman

2020 ◽  
pp. 379-390
Keyword(s):  
African American ◽  
University Of Pennsylvania ◽  
Washington Dc ◽  
John Edgar Wideman ◽  
Oxford University ◽  
Brown University ◽  
University Of Massachusetts ◽  
The University ◽  
To Receive ◽  
Writers Workshop

John Edgar Wideman was born in Washington, DC, and reared in Pittsburgh’s Homewood community, which was predominately African American. At both topranked Peabody High School and the University of Pennsylvania, where he received his BA in 1963, he excelled academically and athletically. He was only the second African American to receive a Rhodes Scholarship (1966) to study at Oxford University. He taught at the University of Iowa’s Writers’ Workshop, the University of Massachusetts at Amherst, Brown University, and other institutions....

scholarly journals Matthew Gentzkow, Winner of the 2014 Clark Medal

2015 ◽  
Vol 29 (1) ◽  
pp. 181-192 ◽  
Author(s):  
Andrei Shleifer
Keyword(s):  
Economic Theory ◽  
Industrial Organization ◽  
Digital Environment ◽  
American Economic Association ◽  
Empirical Industrial Organization ◽  
Economic Association ◽  
Economic Forces ◽  
The Media ◽  
The University

The 2014 John Bates Clark Medal of the American Economic Association was awarded to Matthew Gentzkow of the University of Chicago Booth School of Business. The citation recognized Matt's “fundamental contributions to our understanding of the economic forces driving the creation of media products, the changing nature and role of media in the digital environment, and the effect of media on education and civic engagement.” In addition to his work on the media, Matt has made a number of significant contributions to empirical industrial organization more broadly, as well as to applied economic theory. In this essay, I highlight some of these contributions.

Harold Adams Innis 1894–1952

1953 ◽  
Vol 13 (1) ◽  
pp. 1-1
Author(s):  
Edward C. Kirkland
Keyword(s):  
Economic History ◽  
The United States ◽  
American Economic Association ◽  
University Of Toronto ◽  
Charter Member ◽  
Economic Association ◽  
Learned Societies ◽  
The University ◽  
Canadian Economic History

In a long list of publications since 1923 Harold Innis with industry and insight set a pattern for the study and interpretation of Canadian economic history. The University of Toronto, the Dominion Government, and Canadian learned societies in their various fashions paid tribute to the high quality of this achievement. His career, moreover, was a refutation of his own generalization, perhaps playfully formulated, that no Canadian scholar could secure recognition in the United States. He was a charter member of the Committee on Research in Economic History, the second president of the Economic History Association, and at the time of his death president of the American Economic Association.

Production of New and Revised A.A.V.S.O. Charts

1979 ◽  
Vol 46 ◽  
pp. 368
Author(s):  
Clinton B. Ford
Keyword(s):  
Variable Star ◽  
Standard Form ◽  
Original Data ◽  
University Of Pennsylvania ◽  
Standard Format ◽  
Additional Information ◽  
The Gift ◽  
The University

A “new charts program” for the Americal Association of Variable Star Observers was instigated in 1966 via the gift to the Association of the complete variable star observing records, charts, photographs, etc. of the late Prof. Charles P. Olivier of the University of Pennsylvania (USA). Adequate material covering about 60 variables, not previously charted by the AAVSO, was included in this original data, and was suitably charted in reproducible standard format.Since 1966, much additional information has been assembled from other sources, three Catalogs have been issued which list the new or revised charts produced, and which specify how copies of same may be obtained. The latest such Catalog is dated June 1978, and lists 670 different charts covering a total of 611 variables none of which was charted in reproducible standard form previous to 1966.

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