Is the routine use of antibiotics justified in adult tonsillectomy?

2003 ◽  
Vol 117 (5) ◽  
pp. 382-385 ◽  
Author(s):  
B. J. O’Reilly ◽  
S. Black ◽  
J. Fernandes ◽  
J. Panesar
Keyword(s):  
General Practitioner ◽  
Pain Score ◽  
Prospective Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Post Operative Pain ◽  
Perioperative Antibiotics ◽  
Secondary Haemorrhage ◽  
Gp Visits ◽  
Adult Tonsillectomy

Pain and secondary haemorrhage are the commonest complications of adult tonsillectomy, occurring mostly in the community. This is a randomized, double-blind, placebo-controlled, prospective trial of the effect of perioperative amoxycillin on these complications. The incidence and severity of post-operative haemorrhage was measured. For the first 10 post-operative days patients provided a linear pain score, a record of GP visits, and their use of additional antibiotics and analgesics.Of 95 patients considered: 23 suffered a secondary haemorrhage; 54 consulted their general practitioner (GP) because of pain; additional antibiotics were used by at least 31 and additional analgesics by at least 41. No significant differences were demonstrated between the active and placebo groups for any of these measures.This study demonstrates that secondary haemorrhage is common after adult tonsillectomy. Post-operative pain remains a major problem requiring frequent GP consultations. There appears to be no justification for the routine use of perioperative antibiotics.

Double-Blind Placebo Controlled Oral Analgesic Comparison of Butorphanol and Pentazocine in Patients with Moderate to Severe Post-Operative Pain

1973 ◽  
Vol 1 (2) ◽  
pp. 422-428
Author(s):  
Robert E S Young
Keyword(s):  
The Other ◽  
Dose Effect ◽  
Surgical Patients ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Oral Analgesic ◽  
Post Operative Pain ◽  
Maximum Pain ◽  
Better Than ◽  
Observation Period

A double-blind, randomized trial was conducted in 120 post-surgical patients to evaluate the oral analgesic activity of butorphanol tartrate (4 mg and 8 mg) and pentazocine HCl (50 mg) as compared to placebo. Both doses of butorphanol as well as pentazocine proved to be significantly (p <0.05) more effective than placebo. Butorphanol 4 mg and pentazocine 50 mg were never significantly different from each other, while butorphanol 8 mg was significantly better than both butorphanol 4 mg as well as pentazocine 50 mg in several instances, demonstrating a significant dose effect relationship for butorphanol. All of the active treatments provided maximum pain relief within 1 to 2 hours and were effective over 4 hours. In contrast to the other treatments, none of the 8 mg butorphanol patients required remedication during the 4-hour observation period. Generally, the incidence of side-effects appeared low.

Fenugreek dermal patch, a new natural topical antinociceptive medication for relieving the postherniotomy pain, a double-blind placebo controlled trial

2019 ◽  
Vol 16 (3) ◽  
Author(s):  
Mehdi Ansari ◽  
Parvane Sadeghi ◽  
Hamid Mahdavi ◽  
Mohsen Fattahi-Dolatabadi ◽  
Neda Mohamadi ◽  
...  
Keyword(s):  
Pain Score ◽  
Controlled Trial ◽  
Antinociceptive Effect ◽  
Morphine Consumption ◽  
Pain Intensity Score ◽  
Double Blind ◽  
Fenugreek Seeds ◽  
Double Blind Placebo ◽  
Post Surgery ◽  
Dermal Patch

Abstract Background Fenugreek seeds have shown antinociceptive effect in animal studies. This double-blind placebo controlled trial was designed to study the effect of fenugreek transdermal patch 10% (FDP) for management of inguinal hernia (IH) post-operative pain. Methods Standardized extract of fenugreek seeds was used for FDP formulation. Ninety patients treated with 10% FDP, diclofenac dermal patch 1% (DP) and placebo twice daily after IH surgery. The pain intensity score was evaluated using a visual analogue score (VAS) up to 48 h after operation. Morphine consumption and diclofenac suppository demand were evaluated too. Results The pain score was significantly reduced in FDP group in comparison with the placebo group. This effect was also significantly different from DP up to 6 h after surgery (p<0.05). Morphine consumption and diclofenc suppository demand were significantly decreased in FDP group (p<0.05). Conclusion In all, results of the present study indicated that FDP decreases pain score and demand for morphine in post-surgery patients in comparison to diclofenac patch, and this preparation could be a suit option as a natural antinociceptive agent for pain management.

Tramadol in the management of post-operative pain: a double-blind, placebo- and active drug-controlled study

1997 ◽  
Vol 14 (6) ◽  
pp. 646-654 ◽  
Author(s):  
U. M. Stamer ◽  
C. Maier ◽  
S. Grond ◽  
B. Veh-Schmidt ◽  
E. Klaschik ◽  
...  
Keyword(s):  
Active Drug ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Post Operative Pain

scholarly journals THE EFFECTIVENESS OF SPHEROGEL IN THE TREATMENT OF KNEE OSTEOARTHRITIS

2013 ◽  
Vol 4 (3) ◽  
pp. 4-10 ◽  
Author(s):  
R S Saykovskiy ◽  
N A Savenkova ◽  
A V Averyanov ◽  
A V Lisitsa
Keyword(s):  
Knee Osteoarthritis ◽  
Functional Activity ◽  
Prospective Trial ◽  
Intraarticular Injection ◽  
Double Blind ◽  
Good Tolerability ◽  
Double Blind Placebo ◽  
Positive Effect

The resuts of randomized, double-blind, placebo-controlled, prospective trial in parallel groups of evaluation the efficiency safety and tolerability threefold (once a week) intraarticular injection of Spherogel are discussed in the study. It is estimated of positive effect of this medication to simptoms of gonarthritis: reducing of pain and improvement of functional activity of joint with a good tolerability. This effect continuos for least 3 month.

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