Sexually transmissible agent and African Kaposi's sarcoma

1996 ◽  
Vol 7 (1) ◽  
pp. 4-5 ◽  
Author(s):  
Patrick Matondo ◽  
S Sivapalan
Keyword(s):  
Prospective Studies ◽  
Kaposi's Sarcoma ◽  
Central Africa ◽  
Kaposi’S Sarcoma ◽  
Homosexual Men ◽  
High Incidence ◽  
The World ◽  
Male Preponderance ◽  
Analytical Review ◽  
Very High

Kaposi's sarcoma (KS) has a higher incidence in some parts of Africa than anywhere else in the world. Recent studies in western homosexual men with AIDSKS suggest that KS may be caused by a putative sexually transmissible agent. Our analytical review of studies on KS in Africa before and during the AIDS era reveals a disparate epidemiological picture. Its occurrence in sexually inexperienced children; overwhelming male preponderance in an almost exclusively heterosexual population; rarity of concordant couples in areas of very high incidence; sequestration of high incidence to Eastern and Central Africa; and regional variations in incidence even in high-incidence countries are all difficult to reconcile with a conventional sexually transmissible aetiology. There is a need for prospective studies specifically designed to test the hypothesis in Africa. Also, we recommend that studies pursuing the aetiology of KS in western countries be linked with studies in high incidence areas in Africa.

scholarly journals Epidemiology and Genetic Variability of HHV-8/KSHV among Rural Populations and Kaposi’s Sarcoma Patients in Gabon, Central Africa. Review of the Geographical Distribution of HHV-8 K1 Genotypes in Africa

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 175
Author(s):  
Antony Idam Mamimandjiami ◽  
Augustin Mouinga-Ondémé ◽  
Jill-Léa Ramassamy ◽  
Délia Doreen Djuicy ◽  
Philippe V. Afonso ◽  
...  
Keyword(s):  
Kaposi's Sarcoma ◽  
Molecular Diversity ◽  
Central Africa ◽  
Human Herpesvirus ◽  
Kaposi’S Sarcoma ◽  
Buffy Coat ◽  
Rural Populations ◽  
Herpesvirus 8 ◽  
Nuclear Antigens ◽  
Polymerase Chain

Human herpesvirus 8 (HHV-8) is the etiological agent of all forms of Kaposi’s sarcoma (KS). K1 gene studies have identified five major molecular genotypes with geographical clustering. This study described the epidemiology of HHV-8 and its molecular diversity in Gabon among Bantu and Pygmy adult rural populations and KS patients. Plasma antibodies against latency-associated nuclear antigens (LANA) were searched by indirect immunofluorescence. Buffy coat DNA samples were subjected to polymerase chain reaction (PCR) to obtain a K1 gene fragment. We studied 1020 persons; 91% were Bantus and 9% Pygmies. HHV-8 seroprevalence was 48.3% and 36.5% at the 1:40 and 1:160 dilution thresholds, respectively, although the seroprevalence of HHV-8 is probably higher in Gabon. These seroprevalences did not differ by sex, age, ethnicity or province. The detection rate of HHV-8 K1 sequence was 2.6% by PCR. Most of the 31 HHV-8 strains belonged to the B genotype (24), while the remaining clustered within the A5 subgroup (6) and one belonged to the F genotype. Additionally, we reviewed the K1 molecular diversity of published HHV-8 strains in Africa. This study demonstrated a high seroprevalence of HHV-8 in rural adult populations in Gabon and the presence of genetically diverse strains with B, A and also F genotypes.

RISK FACTORS FOR KAPOSI'S SARCOMA IN HOMOSEXUAL MEN

The Lancet ◽  
1982 ◽  
Vol 319 (8281) ◽  
pp. 1083-1087 ◽  
Author(s):  
Michael Marmor ◽  
Linda Laubenstein ◽  
DanielC. William ◽  
AlvinE. Friedman-Kien ◽  
R.David Byrum ◽  
...  
Keyword(s):  
Risk Factors ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Homosexual Men

Hematologic Manifestations in Homosexual Men With Kaposi’s Sarcoma

1984 ◽  
Vol 132 (1) ◽  
pp. 195-195
Author(s):  
D.I. Abrams ◽  
E.K. Chinn ◽  
B.J. Lewis ◽  
P.A. Volberding ◽  
M.A. Conant ◽  
...  
Keyword(s):  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Homosexual Men

Kaposi's Sarcoma Complicating Immunosuppressive Therapy for Angioimmunoblastic Lymphadenopathy with Dysproteinemia

1982 ◽  
Vol 68 (6) ◽  
pp. 537-542 ◽  
Author(s):  
Mario Cazzola ◽  
Gaetano Bergamaschi ◽  
Alessandro Castello ◽  
Corrado Del Forno ◽  
Laura Dezza ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Immunosuppressive Therapy ◽  
Combination Chemotherapy ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Homosexual Men ◽  
Conservative Approach ◽  
Internal Organs ◽  
Angioimmunoblastic Lymphadenopathy

Cutaneous and visceral dissemination of Kaposi's sarcoma (KS) occurred in a patient with angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) who had been treated with combination chemotherapy. Three other cases of KS complicating immunosuppressive therapy of AILD have been reported in the literature, and there is evidence to indicate that AILD displays features which are known to predispose to KS. Like in other subjects with profound immunodeficiency (e.g. in young homosexual men), in our patient KS pursued an unusually aggressive course, with involvement of lymph nodes and internal organs as well as the skin. It is concluded that the risk of developing severe KS is a further reason to avoid aggressive combination chemotherapy in patients with AILD, particularly in those of Jewish or Mediterranean ancestry. Even the use of corticosteroids should be reduced to a minimum to avoid immunosuppression, and a conservative approach to treatment seems advisable.

Acute radiodermatitis following radiotherapy for classic Kaposi's sarcoma

1993 ◽  
Vol 83 (8) ◽  
pp. 442-446 ◽  
Author(s):  
CG Kissel ◽  
RP Mistretta
Keyword(s):  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Radiation Toxicity ◽  
High Incidence

There is a high incidence of radiation toxicity associated with Kaposi's sarcoma. The authors review acute radiodermatitis and present a case where it occurred in the foot following radiotherapy for classic Kaposi's sarcoma.

Risk of non-Hodgkin lymphoma and Kaposi's sarcoma in homosexual men

The Lancet ◽  
1990 ◽  
Vol 336 (8709) ◽  
pp. 248-249 ◽  
Author(s):  
CharlesS Rabkin ◽  
JamesJ Goedert
Keyword(s):  
Hodgkin Lymphoma ◽  
Kaposi's Sarcoma ◽  
Kaposi’S Sarcoma ◽  
Homosexual Men ◽  
Non Hodgkin Lymphoma
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