MRI surveillance for women with a personal history of breast cancer: comparison between abbreviated and full diagnostic protocol

Objective: To compare the diagnostic performance of breast MRI with abbreviated protocol (AB-MRI) and full ddiagnostic protocol (FDP-MRI) for surveillance of females with a personal history of breast cancer Methods: In this retrospective study, we analyzed the outcomes of total 1312 post-operative screening breast MRI matched from 1045 AB-MRI and 677 FDP-MRI, which had histologic confirmation for suspicious MRI findings or 1 year negative follow-up images. This study was approved by the institutional review board and informed patient consent was waved. AB-MRI consists of T2 weighted scanning and dynamic contrast-enhanced imaging including one pre-contrast and two post-contrast scans. We compared the diagnostic performance for recurrent breast cancer in terms of sensitivity, specificity, positive-predictive value, negative-predictive value, and accuracy and area under the curve between the screening AB-MRI and FDP-MRI. Results: Overall, 13 recurrent tumors among 1312 post-operative cases screened with breast MRI (1.0%) were detected including 8 invasive cancer, 2 cases of in situ cancer, and 3 cases of metastatic lymph nodes. The sensitivity and negative predictive value were 70 vs 100 and 99.5% vs 100% in AB-MRI and FDP-MRI. Specificity, positive predictive value, accuracy, and area under the curve of AB-MRI and FDP-MRI were 98.0% vs 96.9%, 35.0% vs 23.1%, 97.6% vs 97.0%, and 0.840 vs 0.985, respectively. Conclusion: The performance of AB-MRI was comparable to that of FDP-MRI in detecting recurrent breast cancer and decreased false positive cases. Advances in knowledge: AB-MRI provides a reliable alternative with similar diagnostic performance and shorter MRI acquisition time.

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Should Women with a Personal History of Breast Cancer be Screened with Breast MRI?

Breast Diseases A Year Book Quarterly ◽

10.1016/j.breastdis.2012.01.053 ◽

2012 ◽

Vol 23 (1) ◽

pp. 18-19

Author(s):

Bonnie N. Joe

Keyword(s):

Breast Cancer ◽

Breast Mri ◽

Personal History ◽

History Of

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Breast MRI Screening of Women With a Personal History of Breast Cancer

Breast Diseases A Year Book Quarterly ◽

10.1016/j.breastdis.2011.03.029 ◽

2011 ◽

Vol 22 (2) ◽

pp. 140-141

Author(s):

S.E. Harms

Keyword(s):

Breast Cancer ◽

Breast Mri ◽

Personal History ◽

History Of

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Predictive value of serum medroxyprogesterone acetate concentration for response in advanced or recurrent breast cancer

European Journal of Cancer ◽

10.1016/s0959-8049(97)00125-1 ◽

1997 ◽

Vol 33 (9) ◽

pp. 1407-1412 ◽

Cited By ~ 8

Author(s):

R. Nishimura ◽

K. Nagao ◽

M. Matsuda ◽

K. Baba ◽

Y. Matsuoka ◽

...

Keyword(s):

Breast Cancer ◽

Medroxyprogesterone Acetate ◽

Predictive Value ◽

Recurrent Breast Cancer ◽

Acetate Concentration ◽

Recurrent Breast

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Benign dermoscopic parallel ridge pattern in plantar hyperpigmentation due to capecitabine

Dermatology Practical & Conceptual ◽

10.5826/dpc.0502a14 ◽

2015 ◽

pp. 79-81

Author(s):

Linda Tognetti ◽

Michele Fimiani ◽

Pietro Rubegni

Keyword(s):

Breast Cancer ◽

Adjuvant Chemotherapy ◽

Outpatient Clinic ◽

Recurrent Breast Cancer ◽

Eccrine Gland ◽

Drug Induced ◽

The Past ◽

Ridge Pattern ◽

History Of ◽

Recurrent Breast

We report the case of a 37-year-old woman (phototype II) who presented at our outpatient clinic with a two-month history of hyperpigmented plantar macules. Medical history revealed that the patient had taken capecitabine in the past three months as adjuvant chemotherapy for recurrent breast cancer. Dermoscopic examination of the plantar macules showed parallel ridge pattern with pigmentation in the furrows without obliteration of eccrine gland apertures. Besides in acral melanoma, parallel ridge pattern can also be observed in benign plantar lesions, such as congenital or acquired acral nevi, subcorneal hemorrhage, dye-related pigmentation and drug-induced hyperpigmentation, especially in patients with phototypes III-VI. The few reported cases of capecitabine-induced hyperpigmentation have been associated with hand and foot syndrome in patients with phototypes IV-V and palmar as well as plantar involvement.

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Assessment of predictors and prognostic factors for locoregional recurrent breast cancer

International Surgery Journal ◽

10.18203/2349-2902.isj20185489 ◽

2018 ◽

Vol 6 (1) ◽

pp. 287

Author(s):

Hossam A. Elfol ◽

Tarek M. Rageh ◽

Mohammed A. Hamed

Keyword(s):

Breast Cancer ◽

Prognostic Factors ◽

Safety Margin ◽

Radical Mastectomy ◽

Recurrent Breast Cancer ◽

Oral Contraceptive Pills ◽

Female Patients ◽

History Of ◽

Recurrent Breast ◽

Locoregional Recurrent Breast Cancer

Background: Assessment of predictors and prognostic factors of locoregional recurrent breast cancer will help in management of those patients. The aim of this study was to assess and identify the predictors and prognostic factors for locoregional current breast cancer.Methods: This prospective study will be carried out on 50 female patients with history of breast cancer underwent surgical procedures either modified radical mastectomy (MRM) or conservative breast surgery (CBS) and adjuvant therapy (chemotherapy, radiotherapy, hormonal therapy).Results: Significant relationship between recurrence of breast cancer and Oral contraceptive pills of the studied female patients with history of breast cancer underwent surgery.Conclusions: Number of positive lymph nodes, lympho-vascular invasion, positive safety margin and presence of extensive intra-ductal component all these factors increase risk of recurrent breast cancer.

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Breast MRI Screening of Women With a Personal History of Breast Cancer

Yearbook of Oncology ◽

10.1016/j.yonc.2011.10.019 ◽

2011 ◽

Vol 2011 ◽

pp. 40-42

Author(s):

S.E. Harms

Keyword(s):

Breast Cancer ◽

Breast Mri ◽

Personal History ◽

History Of

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FDG-PET/CT in the diagnosis of recurrent breast cancer

Acta Radiologica ◽

10.1258/ar.2011.110245 ◽

2012 ◽

Vol 53 (1) ◽

pp. 12-16 ◽

Cited By ~ 25

Author(s):

Ryusuke Murakami ◽

Shin-ichiro Kumita ◽

Tamiko Yoshida ◽

Keiichi Ishihara ◽

Tomonari Kiriyama ◽

...

Keyword(s):

Breast Cancer ◽

Predictive Value ◽

Cancer Recurrence ◽

Final Diagnosis ◽

Recurrent Breast Cancer ◽

Whole Body ◽

Positron Emission ◽

Pet Ct ◽

The Difference ◽

Recurrent Breast

Background An advantage of PET/CT has been demonstrated for diagnosis of several tumor entities. In patients with breast cancer, early diagnosis and accurate restaging of recurrence after surgery is important for selection of the most appropriate therapeutic strategy. Purpose To evaluate the accuracy of integrated positron emission tomography and computed tomography (PET/CT) using 18F-fluorodeoxyglucose (FDG), for follow-up of patients with suspected recurrent breast cancer. Material and Methods Forty-seven patients with suspected recurrent breast cancer underwent PET/CT. The PET and PET/CT images were interpreted without knowledge of the results of other diagnostic modalities, and compared with each other with reference to the final diagnosis. Results Twenty-five (53%) patients suffered tumor recurrence. The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET/CT were 96%, 91%, 92%, 95%, and 94%, respectively. In comparison with PET, PET/CT had a higher sensitivity and accuracy (96% vs. 80% and 94% vs. 81%, respectively). The difference in diagnostic accuracy between PET/CT and PET was significant ( P < 0.05). Conclusion The present findings indicate that PET/CT is an accurate, sensitive and reliable modality for screening and detection of breast cancer recurrence. PET/CT appears to be an effective surveillance tool, as it is able to cover the whole body in a single procedure and shows good performance.

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