Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum

2006 ◽  
Vol 79 (942) ◽  
pp. 510-517 ◽  
Author(s):  
C F Arlett ◽  
P N Plowman ◽  
P B Rogers ◽  
C N Parris ◽  
F Abbaszadeh ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Xeroderma Pigmentosum ◽  
Radiation Sensitivity

Minimal ionizing radiation sensitivity in a large cohort of xeroderma pigmentosum fibroblasts

2008 ◽  
Vol 81 (961) ◽  
pp. 51-58 ◽  
Author(s):  
C F Arlett ◽  
M H L Green ◽  
P B Rogers ◽  
A R Lehmann ◽  
P N Plowman
Keyword(s):  
Ionizing Radiation ◽  
Xeroderma Pigmentosum ◽  
Radiation Sensitivity ◽  
Large Cohort ◽  
Xeroderma Pigmentosum Fibroblasts

Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity

2006 ◽  
Vol 344 (3) ◽  
pp. 821-826 ◽  
Author(s):  
Kanaklata Roy ◽  
Lilin Wang ◽  
G. Mike Makrigiorgos ◽  
Brendan D. Price
Keyword(s):  
Ionizing Radiation ◽  
Glioma Cells ◽  
Radiation Sensitivity

MP98-04 DEFECTIVE ERCC2 CONFERS INCREASED CISPLATIN AND IONIZING RADIATION SENSITIVITY IN BLADDER CANCER CELLS

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Qiang Li ◽  
Andrew Bell ◽  
Emmet Jordan ◽  
Sizhi Gao ◽  
Jennifer Ma ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Radiation Sensitivity ◽  
Bladder Cancer Cells

scholarly journals Radiation-sensitive mutants of Arabidopsis thaliana.

Genetics ◽  
1995 ◽  
Vol 140 (2) ◽  
pp. 725-732 ◽  
Author(s):  
M E Jenkins ◽  
G R Harlow ◽  
Z Liu ◽  
M A Shotwell ◽  
J Ma ◽  
...  
Keyword(s):  
Arabidopsis Thaliana ◽  
Ionizing Radiation ◽  
Genetic Markers ◽  
Uv Light ◽  
Leaf Tissue ◽  
Radiation Sensitivity ◽  
Complementation Group ◽  
Chromosome 1 ◽  
Molecular Defects ◽  
Uv Sensitivity

Abstract Five Arabidopsis mutants have been isolated on the basis of hypersensitivity of leaf tissue to UV light. For each mutant, the UV-hypersensitive phenotype (uvh) was inherited as a single recessive Mendelian trait. In addition, each uvh mutant represented a separate complementation group. Three of the mutations producing the UV hypersensitive phenotype have been mapped relative to either genetic markers or physical microsatellite polymorphisms. Locus UVH1 is linked to nga76 on chromosome 5, UVH3 to GL1 on chromosome three, and UVH6 to nga59 on chromosome 1. Each uvh mutant has a characteristic pattern of sensitivity based on UV sensitivity of leaf tissue, UV sensitivity of root tissue, and ionizing radiation sensitivity of seeds. On the basis of these patterns, possible molecular defects in these mutants are discussed.

scholarly journals Induction of DNA breakage in X-irradiated nucleoids selectively stripped of nuclear proteins in two mouse lymphoma cell lines differing in radiosensitivity.

1998 ◽  
Vol 45 (3) ◽  
pp. 701-704 ◽  
Author(s):  
M Kruszewski ◽  
T Iwaneńko
Keyword(s):  
Dna Damage ◽  
Ionizing Radiation ◽  
Cell Lines ◽  
Radiation Sensitivity ◽  
Lymphoma Cell ◽  
Nuclear Proteins ◽  
Strand Breaks ◽  
Dna Damaging Agents ◽  
Mouse Lymphoma

The role of nuclear proteins in protection of DNA against ionizing radiation and their contribution to the radiation sensitivity was examined by an alkaline version of comet assay in two L5178Y (LY) mouse lymphoma cell lines differing in sensitivity to ionizing radiation. LY-S cells are twice more sensitive to ionizing radiation than LY-R cells (D0 values of survival curves are 0.5 Gy and 1 Gy, respectively). Sequential removal of nuclear proteins by extraction with NaCl of different concentrations increased the X-ray induced DNA damage in LY-R nucleoids. In contrast, in the radiation sensitive LY-S cell line, depletion of nuclear proteins practically did not affect DNA damage. Although there is no doubt that the main cause of LYS cells' sensitivity to ionizing radiation is a defect in the repair of double-strand breaks, our data support the concept that nuclear matrix organisation may contribute to the cellular susceptibility to DNA damaging agents.

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