scholarly journals Evidências do efeito da terapia fotodinâmica sobre a Propionibacterium acnes

2018 ◽  
Vol 6 (3) ◽  
pp. 269
Author(s):  
Rogério Rodrigo Ramos ◽  
Jeferson Leandro De Paiva ◽  
Nagib Pezati Boer ◽  
Luis Fernando Ricci Boer ◽  
Fernando Batigália ◽  
...  
Keyword(s):  
Propionibacterium Acnes

Introdução: A Propionibacterium acnes é uma bactéria causadora da acne. Devido aos efeitos colaterais ou à falta de resposta ao tratamento da acne, foi proposta a terapia fotodinâmica como um tratamento alternativo para a acne. Objetivo: O objetivo foi evidenciar a ação fotodinâmica do LED vermelho 660 nm e do fotossensibilizador azul de metileno sobre Propionibacterium acnes in vitro. Métodos: Os ensaios foram constituídos por quatro grupos: 1. controle (sem aplicação de luz e sem fotossensibilizador); 2. com aplicação de luz; 3. com fotossensibilizador e sem aplicação de luz; 4. com fotossensibilizador e com aplicação de luz. Os ensaios foram submetidos a aplicação de luz por 4 ciclos de 5 minutos com intervalos de 3 minutos. Resultados: Houve redução estatisticamente significante (p<0,05) nas médias dos grupos 1, 2 e 4, ainda que o grupo 3 não tenha apresentado significância estatística, mas houve redução detectada nas médias. Conclusão: A ação fotodinâmica é eficiente para a destruição do material biológico por irradiação a 660nm atribuída ao processo de fotossensibilização pela presença do fotossensibilizador.

scholarly journals In VitroAntibacterial Activity of NB-003 against Propionibacterium acnes

2011 ◽  
Vol 55 (9) ◽  
pp. 4211-4217 ◽  
Author(s):  
J. Pannu ◽  
A. McCarthy ◽  
A. Martin ◽  
T. Hamouda ◽  
S. Ciotti ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Propionibacterium Acnes ◽  
Resistant Mutant ◽  
Microtiter Plate ◽  
Content Type ◽  
Oil In Water ◽  
Complete Disruption ◽  
Kinetics Of ◽  
Gel Formulations

ABSTRACTNB-003 and NB-003 gel formulations are oil-in-water nanoemulsions designed for use in bacterial infections.In vitrosusceptibility ofPropionibacterium acnesto NB-003 formulations and comparator drugs was evaluated. Both NB-003 formulations were bactericidal against allP. acnesisolates, including those that were erythromycin, clindamycin, and/or tetracycline resistant. In the absence of sebum, the MIC90s/minimum bactericidal concentrations (MBC90s) for NB-003, NB-003 gel, salicylic acid (SA), and benzoyl peroxide (BPO) were 0.5/2.0, 1.0/2.0, 1,000/2,000, and 50/200 μg/ml, respectively. In the presence of 50% sebum, the MIC90s/MBC90s of NB003 and BPOs increased to 128/1,024 and 400/1,600 μg/ml, respectively. The MIC90s/MBC90s of SA were not significantly impacted by the presence of sebum. A reduction in the MBC90s for NB-003 and BPO was observed when 2% SA or 0.5% BPO was integrated into the formulation, resulting in MIC90s/MBC90s of 128/256 μg/ml for NB003 and 214/428 μg/ml for BPO. The addition of EDTA enhanced thein vitroefficacy of 0.5% NB-003 in the presence or absence of 25% sebum. The addition of 5 mM EDTA to each well of the microtiter plate resulted in a >16- and >256-fold decrease in MIC90and MBC90, yielding a more potent MIC90/MBC90of ≤1/<1 μg/ml. The kinetics of bactericidal activity of NB-003 againstP. acneswere compared to those of a commercially available product of BPO. Electron micrographs ofP. acnestreated with NB-003 showed complete disruption of bacteria. Assessment of spontaneous resistance ofP. acnesrevealed no stably resistant mutant strains.

scholarly journals Interaction of Propionibacterium acnes with skin lipids in vitro

1993 ◽  
Vol 139 (8) ◽  
pp. 1745-1751 ◽  
Author(s):  
E. M. Gribbon ◽  
W. J. Cunliffe ◽  
K. T. Holland
Keyword(s):  
Propionibacterium Acnes ◽  
Skin Lipids

scholarly journals Inhibitory effects of Euphorbia supina on Propionibacterium acnes-induced skin inflammation in vitro and in vivo

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Hyeon-Ji Lim ◽  
Yong-Deok Jeon ◽  
Sa-Haeng Kang ◽  
Min-Kyoung Shin ◽  
Ki-Min Lee ◽  
...  
Keyword(s):  
Propionibacterium Acnes ◽  
Skin Inflammation ◽  
Inhibitory Effects

The effect of zinc and erythromycin on the growth of erythromycin-resistant and erythromycin-sensitive isolates of Propionibacterium acnes: an in-vitro study

1992 ◽  
Vol 126 (5) ◽  
pp. 505-509 ◽  
Author(s):  
K.T. HOLLAND ◽  
R.A. BOJAR ◽  
W.J. CUNLIFFE ◽  
A.G. CUTCLIFFE ◽  
E.A. EADY ◽  
...  
Keyword(s):  
Propionibacterium Acnes ◽  
In Vitro Study ◽  
Vitro Study

scholarly journals Calcium sulphate mixed with antibiotics does not decrease efficacy against Cutibacterium acnes (formerly Propionibacterium acnes), in vitro study

2020 ◽  
Vol 19 ◽  
pp. 138-142
Author(s):  
Anne Couture ◽  
Valéry Lavergne ◽  
Emilie Sandman ◽  
Jean-Michel Leduc ◽  
Benoit Benoit ◽  
...  
Keyword(s):  
Propionibacterium Acnes ◽  
In Vitro Study ◽  
Calcium Sulphate ◽  
Vitro Study ◽  
Cutibacterium Acnes

scholarly journals Prevention of Propionibacterium acnes biofilm formation in prosthetic infections in vitro

2017 ◽  
Vol 26 (4) ◽  
pp. 553-563 ◽  
Author(s):  
Robert P. Howlin ◽  
Christopher Winnard ◽  
Elizabeth M. Angus ◽  
Connor J. Frapwell ◽  
Jeremy S. Webb ◽  
...  
Keyword(s):  
Biofilm Formation ◽  
Propionibacterium Acnes
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