Mechanism of Hemodynamics and Inflammation during Intracranial Aneurysm Development

Background and Objective: MicroRNAs have been shown to regulate in several pathological process of intracranial aneurysms. The study aimed to estimate whether miRNAs have the potential to become novel biomarkers for intracranial aneurysm rupture. Materials and methods Forty-five ruptured intracranial aneurysm patients were enrolled according to the inclusion criteria, meanwhile thirty-five healthy individuals were recruited in this study. Differentially expressed plasma miRNA profiles were screened in five pairs of patients and controls in microarray study. Then validation was performed in the rest of the objects using quantitative real-time PCR assays. Results: Fourteen significantly changed miRNAs were screened out from patients with aneurysms compared with healthy controls. More than three thousand target genes related to these disregulated miRNAs were found and bioinformatic analysis revealed that these miRNA were involved in intracranial aneurysm development and rupture. Ultimately four miRNAs from screening profile and one supplementary miRNA were demonstrated to be significantly altered. Conclusion: We demonstrated that several miRNAs were differentially expressed among ruptured aneurysm patients and healthy participants, and plasma miRNAs may be novel diagnostic biomarkers in intracranial aneurysm rupture.

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Rare Case of Absent Common Carotid Artery Likely Associated with Intracranial Aneurysm Development

Journal of Stroke and Cerebrovascular Diseases ◽

10.1016/j.jstrokecerebrovasdis.2019.01.017 ◽

2019 ◽

Vol 28 (6) ◽

pp. e77-e80

Author(s):

Youngseok Kwak ◽

Man Kyu Choi ◽

Ki Hong Kim ◽

Jae Hoon Cho

Keyword(s):

Carotid Artery ◽

Intracranial Aneurysm ◽

Common Carotid Artery ◽

Rare Case ◽

Aneurysm Development

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Role of Hemodynamics in Initiation of Aneurysmal Remodeling

ASME 2010 Summer Bioengineering Conference, Parts A and B ◽

10.1115/sbc2010-19537 ◽

2010 ◽

Author(s):

Hui Meng ◽

Sabareesh K. Natarajan ◽

Eleni Metaxa ◽

Markus Tremmel ◽

Ling Gao ◽

...

Keyword(s):

Risk Factors ◽

Shear Stress ◽

Carotid Artery ◽

Wall Shear Stress ◽

Intracranial Aneurysm ◽

Hemodynamic Stress ◽

Key Factor ◽

Aneurysm Development ◽

Wall Shear

Hemodynamic insult has long been speculated to be a key factor in intracranial aneurysm (IA) formation,1 but the specifics of hemodynamic insult contributing to this process are not understood. Despite other risk factors, IAs are predominantly found at locations associated with unique hemodynamic stress such as at the apices of arterial bifurcations or outer curves, prominent in high wall shear stress (WSS) and wall shear stress gradients (WSSG).2 Furthermore, it appears that increased flow at these locations is required to trigger the initiation of aneurysmal remodeling.3 We have previously shown that increasing flow in the rabbit basilar artery (BA), secondary to common carotid artery (CCA) ligation, resulted in nascent aneurysm development at the basilar terminus (BT).4 However, it is unclear if certain hemodynamic stress thresholds must be exceeded to trigger aneurysmal remodeling, and whether sustained insult is necessary.

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