scholarly journals Μελέτη μοριακών δεικτών της οξείας νεφρικής βλάβης στο πλάσμα και στα ούρα κατά την εξωσωματική λιθοθρυψία

2014 ◽  
Author(s):  
Ιωάννης Καρδάκος
Keyword(s):  
Cystatin C ◽  
Interleukin 18 ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

Η λιθίαση αποτελεί την πιο συχνή πάθηση του ουροποιητικού συστήματος και ένα από τα συνηθέστερα επείγοντα ουρολογικά συμβάματα, ενώ διατηρεί μία ευρεία αιτιολογική βάση παθογένειας, επηρεαζόμενη από γενετικά καθορισμένους παράγοντας, όπως και από πλήθος δημογραφικών και περιβαλλοντικών μεταβλητών. Η αντιμετώπιση της λιθίασης τα τελευταία χρόνια πλαισιώνεται από επαναστατικές τεχνολογικές αλλαγές, καθώς πλέον λιγότερο από 5% των περιπτώσεων λιθίασης αντιμετωπίζεται με την παραδοσιακή ανοιχτή χειρουργική μέθοδο. Έτσι, η μέθοδος της εξωσωματικής λιθοτριψίας με την παραγωγή κυμάτων κρούσης εφαρμόζεται ευρέως, παρουσιάζοντας εξαιρετική αποτελεσματικότητα, αν και σε ορισμένες περιπτώσεις ενδέχεται να προκαλέσει νεφρική βλάβη. Τα τελευταία χρόνια, η εξέταση μοριακών δεικτών της οξείας νεφρικής βλάβης μετά την εφαρμογή της εξωσωματικής λιθοθρυψίας είναι εξαιρετικά δημοφιλής, με σκοπό την έγκαιρη διάγνωση και αποτελεσματική αντιμετώπισή της. Σκοπός της παρούσας διδακτορικής διατριβής είναι η εξέταση των μοριακών δεικτών Plasma neutrophil Gelatinase-Associated Lipocalin (NGAL) στο πλάσμα και στα ούρα, cystatin C στο πλάσμα και Interleukin -18 (IL-18) στα ούρα, καθώς οι δείκτες αυτοί έχουν ανεβρεθεί αυξημένοι σε καταστάσεις οξείας νεφρικής βλάβης, έχοντας τη δυνατότητα να αναδείξουν τον βαθμό της νεφρικής βλάβης μετά την εξωσωματική λιθοθρυψία. Σύμφωνα με τα αποτελέσματα αν και οι εξεταζόμενοι μοριακοί δείκτες φαίνεται πως αποτελούν σημαντικούς δείκτες για την αποτελεσματικότητα της εξωσωματικής λιθοθρυψίας και την ιστική κατάσταση του νεφρού μετά την εφαρμογή αυτής της μη επεμβατικής μεθόδου, παρόλα αυτά οι μη στατιστικές διαφορές που επισημάνθηκαν ανάμεσα στα διάφορα ζεύγη των μετρήσεων πριν και μετά την εφαρμογή της μεθόδου καταδεικνύουν πως δεν είναι επαρκείς για την ανάδειξη νεφρικής βλάβης, και για το λόγο αυτό χρήζουν περαιτέρω διερεύνησης. Λέξεις κλειδιά: NGAL, Cystatin C, Interleukin 18, εξωσωματική λιθοτριψία

Evaluation of Neutrophil Gelatinase–associated Lipocalin, Interleukin-18, and Cystatin C as Molecular Markers Before and After Unilateral Shock Wave Lithotripsy

Urology ◽  
2014 ◽  
Vol 84 (4) ◽  
pp. 783-788 ◽  
Author(s):  
Ioannis S. Kardakos ◽  
Demetrios I. Volanis ◽  
Aggeliki Kalikaki ◽  
Vasilleios P. Tzortzis ◽  
Efraim N. Serafetinides ◽  
...  
Keyword(s):  
Shock Wave ◽  
Molecular Markers ◽  
Cystatin C ◽  
Shock Wave Lithotripsy ◽  
Interleukin 18 ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Before And After ◽  
Neutrophil Gelatinase

scholarly journals Serum NGAL, BNP, PTH, and albumin do not improve glomerular filtration rate estimating formulas in children

2021 ◽  
Author(s):  
Julie Mouron-Hryciuk ◽  
François Cachat ◽  
Paloma Parvex ◽  
Thomas Perneger ◽  
Hassib Chehade
Keyword(s):  
Glomerular Filtration Rate ◽  
Parathyroid Hormone ◽  
Serum Creatinine ◽  
Brain Natriuretic Peptide ◽  
Glomerular Filtration ◽  
Natriuretic Peptide ◽  
Cystatin C ◽  
Filtration Rate ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

AbstractGlomerular filtration rate (GFR) is difficult to measure, and estimating formulas are notorious for lacking precision. This study aims to assess if the inclusion of additional biomarkers improves the performance of eGFR formulas. A hundred and sixteen children with renal diseases were enrolled. Data for age, weight, height, inulin clearance (iGFR), serum creatinine, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), parathyroid hormone (PTH), albumin, and brain natriuretic peptide (BNP) were collected. These variables were added to the revised and combined (serum creatinine and cystatin C) Schwartz formulas, and the quadratic and combined quadratic formulas. We calculated the adjusted r-square (r2) in relation to iGFR and tested the improvement in variance explained by means of the likelihood ratio test. The combined Schwartz and the combined quadratic formulas yielded best results with an r2 of 0.676 and 0.730, respectively. The addition of BNP and PTH to the combined Schwartz and quadratic formulas improved the variance slightly. NGAL and albumin failed to improve the prediction of GFR further. These study results also confirm that the addition of cystatin C improves the performance of estimating GFR formulas, in particular the Schwartz formula.Conclusion: The addition of serum NGAL, BNP, PTH, and albumin to the combined Schwartz and quadratic formulas for estimating GFR did not improve GFR prediction in our population. What is Known:• Estimating glomerular filtration rate (GFR) formulas include serum creatinine and/or cystatin C but lack precision when compared to measured GFR.• The serum concentrations of some biological parameters such as neutrophil gelatinase-associated lipocalin (NGAL), parathyroid hormone (PTH), albumin, and brain natriuretic peptide (BNP) vary with the level of renal function. What is New:• The addition of BNP and PTH to the combined quadratic formula improved its performance only slightly. NGAL and albumin failed to improve the prediction of GFR further.

scholarly journals Changes in Urinary and Serum Levels of Novel Biomarkers after Administration of Gadolinium-based Contrast Agents

2016 ◽  
Vol 11 ◽  
pp. BMI.S39199 ◽  
Author(s):  
Habib Mawad ◽  
Louis-Philippe Laurin ◽  
Jean-François Naud ◽  
François A. Leblond ◽  
Nathalie Henley ◽  
...  
Keyword(s):  
Renal Function ◽  
Contrast Agents ◽  
Cystatin C ◽  
Normal Renal Function ◽  
Serum Levels ◽  
Serum Cystatin C ◽  
Baseline Serum ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Novel Biomarkers ◽  
Neutrophil Gelatinase

Objective The aim of our study is to describe the changes in urinary and serum levels of novel biomarkers after gadolinium contrast administration in patients with normal renal function. Methods We measured four biomarkers in 28 volunteers: interleukin-18 (IL-18), N-acetyl-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin, and cystatin C. Urinary and serum samples were collected at 0, 3, and 24 hours following gadolinium administration. Results Baseline serum creatinine was 57.8 ± 34.5 μmol/L and remained stable. Urinary IL-18 levels increased significantly at three hours (10.7 vs. 7.3 ng/mg creatinine; P < 0.05). Similarly, urinary NAG levels increased significantly at three hours (3.9 vs. 2.2 IU/mg creatinine; P < 0.001). For both these markers, the difference was no longer significant at 24 hours. No statistically significant differences were observed for urinary and serum neutrophil gelatinase-associated lipocalin levels and for serum cystatin C levels. Conclusions Urinary IL-18 and NAG levels increased transiently after administration of gadolinium-based contrast agents in patients with normal renal function.

STUDY OF SERUM NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN CONCENTERATIONS AS A MARKER OF RENAL FUNCTION IN CHRONIC KIDNEY DISEASE PATIENTS

2021 ◽  
pp. 189-190
Author(s):  
G.G. Kaushik ◽  
Shubham Maheshwari ◽  
Ankita Sharma
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Kidney Function ◽  
Cystatin C ◽  
Kidney Injury ◽  
Lipocalin 2 ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase ◽  
Sensitive Marker

Introduction: Serum lipocalin 2 serve as a marker for kidney function. Lipocalin 2 is found in both CKD and kidney injury and it rises in acute kidney injury (AKI) and in patients have faster decline in kidney function. Aims And Objectives: To nd out correlation and assess of serum Neutrophil gelatinase-associated lipocalin 2 (NGAL 2) in patients with stages 2 to 4 of Chronic Kidney disease. The aim of the study was NGAL could represent a novel, sensitive marker of kidney function in adult patients with CKD. Material And Methods: Study involved 120 patients divided in Case group (60 patients) attended medical/ urology OPD or admitted in medical/urology ward of CKD2 – CKD4 while control group – age and sex matched healthy individuals/ stage I CKD patients was taken as control. The plasma/ serum were used for serum urea, creatinine, Cystatin C and lipocalin 2 under all aseptic precaution on receiving consent. Result:The patients of CKD included in study were having glomerulonephritis (46.7%), pyelonephritis (21.7%), diabetic kidney disease (13.3%), polycystic kidney disease (1.7%) and other causes (16.7%). CKD patients demonstrated elevated serum NGAL 159.14 ± 48.73 ng/ml, together with a rise in urea 59.9 ± 17.6 mg/dL, serum creatinine 1.56 ± 0.97 mg/dL and Cystatin C 199 ± 113 ng/ml as compared to control have serum NGAL 76.31 ± 26.34 ng/ml, urea 22.3 ± 5.7 mg/dL, serum creatinine 0.75 ± 0.14 mg/dL and Cystatin C 76 ± 17 ng/ml (P value <0.05). Conclusion: Serum NGAL closely correlates with serum Cystatin C, creatinine, and eGFR, and serve as a potential early and sensitive marker of impaired kidney function/ kidney injury.

scholarly journals Predicting Acute Renal Injury in Cancer Patients Receiving Cisplatin Using Urinary Neutrophil Gelatinase-Associated Lipocalin and Cystatin C

2018 ◽  
Vol 11 (4) ◽  
pp. 420-427 ◽  
Author(s):  
Michael J. Jelinek ◽  
Sang Mee Lee ◽  
Alicia Wyche Okpareke ◽  
Claudia Wing ◽  
Jay L. Koyner ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Cystatin C ◽  
Renal Injury ◽  
Acute Renal Injury ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

scholarly journals Kidney Biomarkers and Decline in eGFR in Patients with Type 2 Diabetes

2018 ◽  
Vol 13 (3) ◽  
pp. 398-405 ◽  
Author(s):  
Katherine G. Garlo ◽  
William B. White ◽  
George L. Bakris ◽  
Faiez Zannad ◽  
Craig A. Wilson ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Confidence Interval ◽  
Cystatin C ◽  
Hazard Ratio ◽  
Clinical Factors ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
C Statistic ◽  
Neutrophil Gelatinase ◽  
Egfr Decline

Background and objectivesBiomarkers may improve identification of individuals at risk of eGFR decline who may benefit from intervention or dialysis planning. However, available biomarkers remain incompletely validated for risk stratification and prediction modeling.Design, setting, participants, & measurementsWe examined serum cystatin C, urinary kidney injury molecule–1 (uKIM-1), and urinary neutrophil gelatinase-associated lipocalin (UNGAL) in 5367 individuals with type 2 diabetes mellitus and recent acute coronary syndromes enrolled in the Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care (EXAMINE) trial. Baseline concentrations and 6-month changes in biomarkers were also evaluated. Cox proportional regression was used to assess associations with a 50% decrease in eGFR, stage 5 CKD (eGFR<15 ml/min per 1.73 m2), or dialysis.ResultseGFR decline occurred in 98 patients (1.8%) over a median of 1.5 years. All biomarkers individually were associated with higher risk of eGFR decline (P<0.001). However, when adjusting for baseline eGFR, proteinuria, and clinical factors, only baseline cystatin C (adjusted hazard ratio per 1 SD change, 1.66; 95% confidence interval, 1.41 to 1.96; P<0.001) and 6-month change in urinary neutrophil gelatinase-associated lipocalin (adjusted hazard ratio per 1 SD change, 1.07; 95% confidence interval, 1.02 to 1.12; P=0.004) independently associated with CKD progression. A base model for predicting kidney function decline with nine standard risk factors had strong discriminative ability (C-statistic 0.93). The addition of baseline cystatin C improved discrimination (C-statistic 0.94), but it failed to reclassify risk categories of individuals with and without eGFR decline.ConclusionsThe addition of cystatin C or biomarkers of tubular injury did not meaningfully improve the prediction of eGFR decline beyond common clinical factors and routine laboratory data in a large cohort of patients with type 2 diabetes and recent acute coronary syndrome.PodcastThis article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2018_01_16_CJASNPodcast_18_3_G.mp3

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