Case Report: Kikuchi: The great mimicker

Kikuchi-Fujimoto disease is a form of a benign necrotizing lymphadenitis which is most commonly misdiagnosed as tuberculosis and or lymphoma, usually more common among young adults in Asia. It is a benign disease but can mimic a lot of other disease processes spanning infectious, rheumatologic and even hematologic malignancies. Our patient presented with prolonged fever and lymphadenopathy. Initial considerations were lymphoma and a nonspecific viral infection. A CT scan showed diffuse cervical lymphadenopathy with lacrimal gland involvement. An excisional lymph node biopsy was done which revealed Kikuchi disease. Patient was given steroids with immediate response with defervescence. Kikuchi is a disease with many mimics and a complete workup is needed to exclude serious disease like malignancy.

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Kikuchi necrotizing lymphadenopathy: a tip of the iceberg disease?

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20213326 ◽

2021 ◽

Vol 8 (9) ◽

pp. 1602

Author(s):

Sushil Singla ◽

Mohitesh Kumar ◽

Vinod Kumar Jat ◽

Deepika Parwan

Keyword(s):

Lymph Node ◽

Laboratory Test ◽

Young Patient ◽

Healthy Individual ◽

Cervical Lymphadenopathy ◽

Lymph Node Biopsy ◽

Histiocytic Necrotizing Lymphadenitis ◽

Benign Condition ◽

Node Biopsy ◽

Necrotizing Lymphadenitis

Kikuchi-Fujimoto disease (KFD) is a rare benign condition also called histiocytic necrotizing lymphadenitis, which typically presented as fever with cervical lymphadenopathy in previously healthy individual. We presented a case of 11 year old boy with fever and cervical lymphadenopathy since 2 months. Lymph node biopsy was performed which suggested of KFD and was treated symptomatically. KFD incidence is rare but clinicians should be alert if young patient comes with fever and cervical lymphadenopathy to lower the chance of unwanted laboratory test and harmful treatment.

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Kikuchi-Fujimoto Disease: A Rare Cause of Fever in the Returning Traveller

Case Reports in Medicine ◽

10.1155/2014/868190 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4

Author(s):

Matthew R. Wilson ◽

Gordon Milne ◽

Evangelos Vryonis

Keyword(s):

Case Report ◽

Lymph Node ◽

Autoimmune Disorder ◽

Lymph Node Biopsy ◽

Supportive Treatment ◽

Neck Swelling ◽

Travel History ◽

Node Biopsy ◽

Wide Range ◽

Necrotizing Lymphadenitis

Background.Kikuchi-Fujimoto disease (KFD) is typically a self-limited, benign illness which presents with fever and lymphadenopathy. It is rare in Caucasians, normally occurring in those of Asian descent. The aetiology is poorly understood, but it appears to be an autoimmune disorder with a possible infectious trigger. The clinical features are such that it is often mistaken for infectious diseases or malignancy.Case Report.Here we describe a case of a 36-year-old Asian man who presented following a recent trip to Delhi, India. He described fever, neck swelling, and arthralgia. Given his travel history an infectious cause for his presentation was presumed but multiple investigations were negative. Persistence of his symptoms led to lymph node biopsy to investigate for malignancy; surprisingly this revealed a necrotizing lymphadenitis in keeping with KFD. The patient made a full recovery with supportive treatment only.Conclusion.This case presented an opportunity to reflect on two common presenting complaints—fever in the returning traveller and unexplained lymphadenopathy. Both presentations have a wide range of aetiologies to consider. Although KFD is rare, it is an important diagnosis to make as it can prevent further expensive and invasive investigations, as well as potentially harmful treatments and psychological stress to the patient.

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Blue Skin Rash And Swelling Of The Orbits After Injection Of Patent Blue V Dye During Sentinel Lymph Node Biopsy - A Case Report

Polish Journal of Surgery ◽

10.2478/v10035-010-0085-y ◽

2010 ◽

Vol 82 (10) ◽

Author(s):

Łukasz Strzępek ◽

Wojciech Wysocki ◽

Piotr Skotnicki ◽

Jerzy Mituś

Keyword(s):

Case Report ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Sentinel Lymph Node Biopsy ◽

Skin Rash ◽

Lymph Node Biopsy ◽

Patent Blue ◽

Node Biopsy ◽

Patent Blue V

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Sentinel lymph node biopsy in periocular merkel cell carcinoma: a case report

BMC Research Notes ◽

10.1186/s13104-017-2746-y ◽

2017 ◽

Vol 10 (1) ◽

Cited By ~ 2

Author(s):

Dan C. Filitis ◽

Gyorgy Paragh ◽

Faramarz H. Samie ◽

Nathalie C. Zeitouni

Keyword(s):

Case Report ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Sentinel Lymph Node Biopsy ◽

Cell Carcinoma ◽

Merkel Cell Carcinoma ◽

Lymph Node Biopsy ◽

Merkel Cell ◽

Node Biopsy

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Intratumoral versus subareolar injection in breast cancer sentinel lymph node biopsy. A case report

Revista Española de Medicina Nuclear (English Edition) ◽

10.1016/s1578-200x(11)70023-7 ◽

2011 ◽

Vol 30 (3) ◽

pp. 171-173

Author(s):

I. Lanchas Alfonso ◽

M.B. Miguel Martínez ◽

J.F. CuezvaGuzmán ◽

P. Rupérez Arribas ◽

S. Martínez Blanco ◽

...

Keyword(s):

Breast Cancer ◽

Case Report ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Sentinel Lymph Node Biopsy ◽

Lymph Node Biopsy ◽

Subareolar Injection ◽

Node Biopsy

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Kikuchi-Fujimoto Disease: A Report of 3 Cases

Ear Nose & Throat Journal ◽

10.1177/014556130708600720 ◽

2007 ◽

Vol 86 (7) ◽

pp. 412-413 ◽

Cited By ~ 4

Author(s):

Eimear Phelan ◽

Emer Lang ◽

Peter Gormley ◽

John Lang

Keyword(s):

Weight Loss ◽

Cervical Lymphadenopathy ◽

Lymph Node Biopsy ◽

Accurate Diagnosis ◽

Histiocytic Necrotizing Lymphadenitis ◽

Kikuchi’S Disease ◽

Node Biopsy ◽

Night Sweats ◽

Necrotizing Lymphadenitis ◽

Kikuchi's Disease

Cervical lymphadenopathy has many underlying etiologies. One of its rare causes is Kikuchi-Fujimoto disease (Kikuchi's disease, histiocytic necrotizing lymphadenitis). We discovered such a cause in a 37-year-old woman who had presented with malaise, night sweats, and weight loss in addition to cervical lymphadenopathy. We based our diagnosis on excisional lymph node biopsy. We also review 2 other cases of Kikuchi's disease that were diagnosed by others at our institution. Clinically and histologically, Kikuchi's disease is very similar to lymphoma, and distinguishing the two is difficult. However, despite the fact that Kikuchi's disease is benign, an accurate diagnosis is important because misdiagnosis might lead to unnecessary surgery and/or chemotherapy.

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