scholarly journals Case Report: Silicosis and IgA nephropathy, an exceptional association

F1000Research ◽  
2022 ◽  
Vol 10 ◽  
pp. 1146
Author(s):  
Ikram Mami ◽  
Jihen Hsinet ◽  
Syrine Tlili ◽  
Hela Jebali ◽  
Ilhem Ben Othmani ◽  
...  
Keyword(s):  
Renal Function ◽  
Iga Nephropathy ◽  
Enzyme Inhibitors ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Exertional Dyspnea ◽  
Converting Enzyme Inhibitors ◽  
Urine Sediment ◽  
Glomerular Proteinuria ◽  
Limb Edema ◽  
Stable Renal Function

A 57-year-old male who had been working in masonry for 33 years was hospitalized for renal function decline associated with exertional dyspnea. He presented with hypertension and limb edema. Urinalysis revealed an active urine sediment with glomerular proteinuria at 1.5 g/24h and the renal biopsy identified mesangial IgA Nephropathy. Chest tomography scans showed signs of silicosis. The patient received Angiotensin-Converting Enzyme Inhibitors with stable renal function. To our knowledge, the association of silicosis-IgA nephropathy has rarely been reported in the literature. This case highlights the effect of chronic exposure to silica dust and its association with both silica and renal disease.

scholarly journals Case Report: Silicosis and IgA nephropathy, an exceptional association

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 1146
Author(s):  
Ikram Mami ◽  
Jihen Hsinet ◽  
Syrine Tlili ◽  
Hela Jebali ◽  
Ilhem Ben Othmani ◽  
...  
Keyword(s):  
Renal Function ◽  
Iga Nephropathy ◽  
Enzyme Inhibitors ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Exertional Dyspnea ◽  
Converting Enzyme Inhibitors ◽  
Urine Sediment ◽  
Glomerular Proteinuria ◽  
Limb Edema ◽  
Stable Renal Function

A 57-year-old male who had been working in masonry for 33 years was hospitalized for renal function decline associated with exertional dyspnea. He presented with hypertension and limb edema. Urinalysis revealed an active urine sediment with glomerular proteinuria at 1.5 g/24h and the renal biopsy identified mesangial IgA Nephropathy. Chest tomography scans showed signs of silicosis. The patient received Angiotensin-Converting Enzyme Inhibitors with stable renal function. To our knowledge, the association of silicosis-IgA nephropathy has rarely been reported in the literature. This case highlights the effect of chronic exposure to silica dust and its association with both silica and renal disease.

scholarly journals Impact of Renin-Angiotensin Aldosterone System Inhibition on Serum Potassium Levels among Peritoneal Dialysis Patients

2017 ◽  
Vol 46 (2) ◽  
pp. 150-155 ◽  
Author(s):  
Silvia Carreira Ribeiro ◽  
Ana Elizabeth Figueiredo ◽  
Pasqual Barretti ◽  
Roberto Pecoits-Filho ◽  
Thyago Proença de Moraes ◽  
...  
Keyword(s):  
Renal Function ◽  
Peritoneal Dialysis ◽  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibitors ◽  
Serum Levels ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Converting Enzyme ◽  
Dialysis Patients ◽  
Converting Enzyme Inhibitors ◽  
Renin Angiotensin

Background: The chronic use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blocker has been associated with hyperkalemia in patients with reduced renal function even after the initiation of hemodialysis. Whether such medications may cause a similar effect in peritoneal dialysis patients is not well established. So, the aim of our study was to analyze the impact of renin-angiotensin-aldosterone inhibitors on the serum levels of potassium in a national cohort of peritoneal dialysis patients. Method: A prospective, observational, nationwide cohort study was conducted. We identified all incident patients on peritoneal dialysis that had angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB) prescribed for at least 3 months and a similar period of time without these medications. Patients were divided into 4 groups: Groups I and III correspond to patients using, respectively, an ACEi or ARB and then got the drug suspended; Groups II and IV started peritoneal dialysis without the use of any renin-angiotensin aldosterone system inhibitor and then got, respectively, an ACEi or ARB introduced. Changes in potassium serum levels were compared using 2 statistical approaches: (1) the non-parametric Wilcoxon test for repeated measures and (2) a crossover analysis. Results: Mean potassium serum levels at the first phase of the study for Groups I, II, III, and IV were, respectively, 4.46 ± 0.79, 4.33 ± 0.78, 4.41 ± 0.63, and 4.44 ± 0.56. Changes in mean potassium serum levels for Groups I, II, III, and IV were -0.10 ± 0.60, 0.02 ± 0.56, -0.06 ± 0.46, and 0.03 ± 0.50, respectively. Conclusion: The use of ACEi and ARB was not associated with a greater risk for hyperkalemia in stable peritoneal dialysis patients independently of residual renal function.

scholarly journals Favourable Outcome of Scleroderma Renal Crisis

1996 ◽  
Vol 89 (1) ◽  
pp. 49P-50P ◽  
Author(s):  
D A Collins ◽  
S Patel ◽  
J B Eastwood ◽  
B E Bourke
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Enzyme Inhibitors ◽  
Severe Hypertension ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Favourable Outcome ◽  
Scleroderma Renal Crisis ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
Renal Crisis

Severe hypertension and rapidly progressive acute renal failure is a well recognized complication of scleroderma, often referred to as the renal crisis, and widely thought to cause irreversible deterioration in renal function. With the advent of angiotensin-converting-enzyme inhibitors (ACE-I) the outlook for patients with this condition has dramatically improved. We report here one such patient.

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