The role of interventional bronchoscopy in tracheal stenosis

2011 ◽  
Vol 2 (4) ◽  
pp. 7
Keyword(s):  
Tracheal Stenosis ◽  
Interventional Bronchoscopy

scholarly journals The role of interventional bronchoscopy in the management of post-intubation tracheal stenosis: A 20-year experience

Pulmonology ◽  
2019 ◽  
Author(s):  
C. Freitas ◽  
N. Martins ◽  
H. Novais-Bastos ◽  
A. Morais ◽  
G. Fernandes ◽  
...  
Keyword(s):  
Tracheal Stenosis ◽  
Interventional Bronchoscopy ◽  
Post Intubation

scholarly journals Balloon tracheoplasty for tracheal stenosis after prolonged intubation: a simple procedure, but is it effective?

2021 ◽  
Vol 29 (1) ◽  
Author(s):  
Abdallah Nosair ◽  
Mahmoud Singer ◽  
Mohamed Elkahely ◽  
Rezk Abu-Gamila ◽  
Waleed Adel
Keyword(s):  
Tracheal Stenosis ◽  
Balloon Dilatation ◽  
Simple Procedure ◽  
Symptomatic Relief ◽  
Additional Treatment ◽  
Prolonged Intubation ◽  
Midterm Outcome ◽  
History Of ◽  
Balloon Tracheoplasty

Abstract Background Tracheal stenosis following prolonged intubation is a relatively rare but serious problem. This condition is usually managed by surgical or endoscopic interventions. Bronchoscopic balloon dilatation for tracheal stenosis is considered a valuable tool used for the management of tracheal stenosis. In this article, we try to evaluate the role of balloon tracheoplasty in the management of tracheal stenosis and to assess the number of dilatation sessions usually needed as well as the short to midterm outcome. Results This study involved 40 patients with tracheal stenosis diagnosed by computed tomography (neck and chest) and bronchoscopy at the Security Force Hospital in Riyadh, KSA, between January 2013 and August 2018. Patients’ data were retrospectively reviewed and analyzed. Patients’ age ranged between 18 and 60 years. Thirty patients were males (75%); those patients underwent balloon tracheoplasty via dilatation of areas of narrowing using catheter balloon insufflation guided by fiber-optic bronchoscope. Ninety-five percent of the patients had initial success with acceptable dilatation of the stenotic area and improvement of the symptoms. There were no technical or major problems which resulted from the procedure, and no patient complained of severe pain or severe discomfort after the procedure. From the total of 81 BBD sessions, no in-hospital mortality is related to the procedure itself, and ICU stay ranged between 1 and 5 days post-procedure. Among those 40 patients, 16 patients (40%) needed one session, 10 patients (25%) needed two sessions, 8 patients (20%) needed three sessions, and 6 patients (15%) needed more than three sessions of balloon dilatation. Conclusion Balloon tracheoplasty is a simple, safe method and could be a promising and effective approach that offers immediate symptomatic relief for tracheal stenosis in cases with a history of prolonged intubation. It is worth mentioning that BBD is considered as a temporary measure, and most of the cases will need definitive or additional treatment either resection or stent placement.

scholarly journals Role of the impulse oscillometry in the evaluation of tracheal stenosis

Pulmonology ◽  
2018 ◽  
Vol 24 (4) ◽  
pp. 224-230 ◽  
Author(s):  
R. Linhas ◽  
F. Lima ◽  
D. Coutinho ◽  
J. Almeida ◽  
S. Neves ◽  
...  
Keyword(s):  
Tracheal Stenosis ◽  
Impulse Oscillometry

scholarly journals Role of Erythromycin-Regulated Histone Deacetylase-2 in Benign Tracheal Stenosis

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Zhenjie Huang ◽  
Peng Wei ◽  
Luoman Gan ◽  
Tonghua Zeng ◽  
Caicheng Qin ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Tracheal Stenosis ◽  
Type I Collagen ◽  
Rabbit Model ◽  
Immunohistochemical Method ◽  
Type Iii Collagen ◽  
Type I ◽  
Histone Deacetylase 2 ◽  
Budesonide Group

Objective. This study aims to explore the role of erythromycin-regulated histone deacetylase-2 in benign tracheal stenosis. Methods. The rabbit model of tracheal stenosis was established. The rabbits were randomly divided into 8 groups. Histone deacetylase-2 (HDAC2) expression was detected by immunofluorescence. The expression of type I collagen and type III collagen was detected by immunohistochemical method. The expression of TGF-β1, VEGF and IL-8 in serum and alveolar lavage fluid was detected by ELISA. The expression of HDAC2, TGF-β1, VEGF and IL-8 in bronchi of each group was detected by Western blotting method. Results. In Erythromycin (ERY) group, ERY + Budesonide group, ERY + Vorinostat group and ERY + Budesonide + Vorinostat group, the degree of bronchial stenosis was alleviated, and the mucosal epithelium was still slightly proliferated. The effect of ERY combined with other drugs was more obvious. The HDAC2 protein expression increased significantly in ERY group, ERY + Budesonide group and ERY + Budesonide + Vorinostat group and decreased significantly in Vorinostat group, the expression of collagen I and III decreased significantly in ERY group, ERY + Budesonide group and ERY + Budesonide + Vorinostat group (P<0.05). The TGF-β1, IL-8 and VEGF levels decreased significantly in ERY group, ERY + Budesonide group, ERY + Vorinostat group and ERY + Budesonide + Vorinostat group (P<0.05). Conclusions. Erythromycin inhibited inflammation and excessive proliferation of granulation tissue after tracheobronchial mucosal injury by up-regulating the expression of HDAC2, it promoted wound healing and alleviated tracheobronchial stenosis. When combined with budesonide, penicillin and other glucocorticoids and antibiotics, it had a good synergistic effect. However, vorinostat could attenuate erythromycin’s effect by down-regulating the expression of HDAC2. It may have good clinical application prospects in the treatment of tracheal stenosis.

scholarly journals The Role of Systemic Steroids in Postintubation Tracheal Stenosis: A Randomized Clinical Trial

2017 ◽  
Vol 103 (1) ◽  
pp. 246-253 ◽  
Author(s):  
Mohammad Behgam Shadmehr ◽  
Azizollah Abbasidezfouli ◽  
Roya Farzanegan ◽  
Saviz Pejhan ◽  
Abolghasem Daneshvar Kakhaki ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Tracheal Stenosis ◽  
Systemic Steroids

ROLE OF INTERVENTIONAL BRONCHOSCOPY IN TRA-CHEOBRONCHIAL OBSTRUCTION

1996 ◽  
Vol 3 (3) ◽  
pp. 241
Author(s):  
S Feijó ◽  
I Correia ◽  
J Vieira ◽  
M Agarez ◽  
M Freitas e Costa
Keyword(s):  
Interventional Bronchoscopy

scholarly journals Novel insights into the role of hypoxia-inducible factor-1 in the pathogenesis of human post-intubation tracheal stenosis

2013 ◽  
Vol 8 (3) ◽  
pp. 903-908 ◽  
Author(s):  
ZHIGANG CAI ◽  
HAITAO LI ◽  
HEFANG ZHANG ◽  
SHUO HAN ◽  
RUIJIN AN ◽  
...  
Keyword(s):  
Tracheal Stenosis ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1 ◽  
Post Intubation

scholarly journals Tracheal stenosis in prolonged mechanically ventilated patients: prevalence, risk factors, and bronchoscopic management

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Alessandro Ghiani ◽  
Konstantinos Tsitouras ◽  
Joanna Paderewska ◽  
Dieter Munker ◽  
Swenja Walcher ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Tracheal Stenosis ◽  
Percutaneous Tracheostomy ◽  
Binary Logistic Regression Analysis ◽  
Interventional Bronchoscopy ◽  
Mechanically Ventilated ◽  
Ventilated Patients

Abstract Background Various complications may arise from prolonged mechanical ventilation, but the risk of tracheal stenosis occurring late after translaryngeal intubation or tracheostomy is less common. This study aimed to determine the prevalence, type, risk factors, and management of tracheal stenoses in mechanically ventilated tracheotomized patients deemed ready for decannulation following prolonged weaning. Methods A retrospective observational study on 357 prolonged mechanically ventilated, tracheotomized patients admitted to a specialized weaning center over seven years. Flexible bronchoscopy was used to discern the type, level, and severity of tracheal stenosis in each case. We described the management of these stenoses and used a binary logistic regression analysis to determine independent risk factors for stenosis development. Results On admission, 272 patients (76%) had percutaneous tracheostomies, and 114 patients (32%) presented mild to moderate tracheal stenosis following weaning completion, with a median tracheal cross-section reduction of 40% (IQR 25–50). The majority of stenoses (88%) were located in the upper tracheal region, most commonly resulting from localized granulation tissue formation at the site of the internal stoma (96%). The logistic regression analysis determined that obesity (OR 2.16 [95%CI 1.29–3.63], P < 0.01), presence of a percutaneous tracheostomy (2.02 [1.12–3.66], P = 0.020), and cricothyrotomy status (5.35 [1.96–14.6], P < 0.01) were independently related to stenoses. Interventional bronchoscopy with Nd:YAG photocoagulation was a highly effective first-line treatment, with only three patients (2.6%) ultimately referred to tracheal surgery. Conclusions Tracheal stenosis is commonly observed among prolonged ventilated patients with tracheostomies, characterized by localized hypergranulation and mild to moderate airway obstruction, with interventional bronchoscopy providing satisfactory results.

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