scholarly journals Inhibition of the Bacterial Cell Wall Synthesis in vitro by Enduracidin, a New Polypeptide Antibiotic

1969 ◽  
Vol 33 (1) ◽  
pp. 134-137 ◽  
Author(s):  
Michio MATSUHASHI ◽  
Ikuko OHARA ◽  
Yoshihiro YOSHIYAMA
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Cell Wall Synthesis ◽  
Polypeptide Antibiotic

Role of kallikrein-kinin system in pathogenesis of bacterial cell wall-induced inflammation

1991 ◽  
Vol 260 (2) ◽  
pp. G213-G219 ◽  
Author(s):  
R. A. DeLa Cadena ◽  
K. J. Laskin ◽  
R. A. Pixley ◽  
R. B. Sartor ◽  
J. H. Schwab ◽  
...  
Keyword(s):  
Cell Wall ◽  
Acute Phase ◽  
Bacterial Cell ◽  
Chronic Phase ◽  
Bacterial Cell Wall ◽  
Kinin System ◽  
Kallikrein Kinin System ◽  
Bacterial Products

The plasma kallikrein-kinin system is activated in Gram-negative sepsis and typhoid fever, two diseases in which bacterial products have been shown to initiate inflammation. Because a single intraperitoneal injection of bacterial cell wall peptidoglycan-polysaccharide polymers from group A steptococci (PG-APS) into a Lewis rat produces a syndrome of relapsing polyarthritis and anemia, we investigated changes in the role of the kallikrein-kinin system in this model of inflammation. Coagulation studies after injection of PG-APS revealed an immediate and persistent decrease in prekallikrein levels. High-molecular-weight kininogen levels decreased significantly during the acute phase and correlated with the severity of arthritis. Factor XI levels were decreased only during the acute phase. Antithrombin III levels remained unchanged, indicating that neither decreased hepatic synthesis nor disseminated intravascular coagulation caused the decreased plasma contact factors. Plasma T-kininogen (an acute phase protein) was significantly elevated during the chronic phase. PG-APS failed to activate the contact system in vitro. Thus the kallikrein-kinin system plays an important role in this experimental model of inflammation, suggesting that activation of this system may play a role in the pathogenesis of inflammatory bowel disease and rheumatoid arthritis in which bacterial products might be etiologically important.

scholarly journals Molecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Carlos Contreras-Martel ◽  
Alexandre Martins ◽  
Chantal Ecobichon ◽  
Daniel Maragno Trindade ◽  
Pierre-Jean Matteï ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Molecular Architecture ◽  
Cell Wall Synthesis

New insight into the mode of action of vancomycin dimers in bacterial cell wall synthesis

MedChemComm ◽  
2011 ◽  
Vol 2 (4) ◽  
pp. 278 ◽  
Author(s):  
Osamu Yoshida ◽  
Jun Nakamura ◽  
Hidenori Yamashiro ◽  
Kenji Miura ◽  
Sayaka Hayashi ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Mode Of Action ◽  
Bacterial Cell Wall ◽  
Cell Wall Synthesis ◽  
Insight Into

SEQUENCE STUDIES ON BACTERIAL CELL WALL PEPTIDES

1964 ◽  
Vol 42 (11) ◽  
pp. 1553-1559 ◽  
Author(s):  
D. Jušić ◽  
C. Roy ◽  
R. W. Watson
Keyword(s):  
Cell Wall ◽  
Paper Chromatography ◽  
High Voltage ◽  
Bacterial Cell ◽  
Paper Electrophoresis ◽  
Bacterial Cell Wall ◽  
Molar Ratios

Peptides from partial acid hydrolysates of purified mucopeptide from Aerobacter cloacae NRC 492 were isolated by a combination of high-voltage paper electrophoresis and paper chromatography. Three dipeptides (L-ala.D-glu, D-glu.meso-Dap, and meso-Dap.D-ala), two tripeptides (ala.D-glu.meso-Dap and D-glu.meso-Dap.ala, i.e. D-glutamyl.meso-diaminopimelyl.alanine), and a tetrapeptide were partially characterized. Molar ratios, sequence, and optical configurations in a tripeptide from the wall corresponded with those in a uridine diphospho muramyl tripeptide from penicillin-treated cells of the same organism and with those of a tripeptide synthesized in vitro by enzymes from cell sonicates.

scholarly journals A FOLIG ACID LINKED SYSTEM IN BACTERIAL CELL WALL SYNTHESIS?

1971 ◽  
Vol 24 (10) ◽  
pp. 713-714 ◽  
Author(s):  
EUGENE L. DULANEY ◽  
LESLEE M. MARX
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Bacterial Cell Wall ◽  
Cell Wall Synthesis

scholarly journals CsiA is a bacterial cell wall synthesis inhibitor contributing to DNA translocation through the cell envelope

2009 ◽  
Vol 72 (3) ◽  
pp. 779-794 ◽  
Author(s):  
Régis Stentz ◽  
Udo Wegmann ◽  
Mary Parker ◽  
Roy Bongaerts ◽  
Laurie Lesaint ◽  
...  
Keyword(s):  
Cell Wall ◽  
Bacterial Cell ◽  
Cell Envelope ◽  
Bacterial Cell Wall ◽  
Cell Wall Synthesis ◽  
Dna Translocation ◽  
Synthesis Inhibitor ◽  
Cell Wall Synthesis Inhibitor
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