Linkage Disequilibrium and Association Analysis of Hanwoo Steer in Gangwon Region using Bovine SNP50K BeadChip

2017 ◽  
Vol 28 (2) ◽  
pp. 46-55
Author(s):  
Min-Wook Hong ◽  
◽  
So-Young Choi ◽  
Hun Kim ◽  
Song-Yi Yang ◽  
...  
Keyword(s):  
Linkage Disequilibrium ◽  
Association Analysis

Linkage Disequilibrium and Association Analysis of ?-Synuclein and Alcohol and Drug Dependence in Two American Indian Populations

2007 ◽  
Vol 0 (0) ◽  
pp. 070212174136004-??? ◽  
Author(s):  
Jordi Clarimon ◽  
Rebecca R. Gray ◽  
Lindsey N. Williams ◽  
Mary-Anne Enoch ◽  
Robert W. Robin ◽  
...  
Keyword(s):  
Linkage Disequilibrium ◽  
American Indian ◽  
Association Analysis ◽  
Drug Dependence ◽  
Indian Populations

Accounting for Linkage Disequilibrium in Association Analysis of Diverse Populations

2014 ◽  
Vol 38 (3) ◽  
pp. 265-273 ◽  
Author(s):  
Bashira A. Charles ◽  
Daniel Shriner ◽  
Charles N. Rotimi
Keyword(s):  
Linkage Disequilibrium ◽  
Association Analysis ◽  
Diverse Populations

scholarly journals Primo: integration of multiple GWAS and omics QTL summary statistics for elucidation of molecular mechanisms of trait-associated SNPs and detection of pleiotropy in complex traits

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Kevin J. Gleason ◽  
Fan Yang ◽  
Brandon L. Pierce ◽  
Xin He ◽  
Lin S. Chen
Keyword(s):  
Linkage Disequilibrium ◽  
Association Analysis ◽  
Complex Traits ◽  
Molecular Mechanisms ◽  
Integrative Analysis ◽  
Pleiotropic Effects ◽  
Summary Statistics ◽  
Susceptibility Loci ◽  
Conditional Association ◽  
Study Heterogeneity

Abstract To provide a comprehensive mechanistic interpretation of how known trait-associated SNPs affect complex traits, we propose a method, Primo, for integrative analysis of GWAS summary statistics with multiple sets of omics QTL summary statistics from different cellular conditions or studies. Primo examines association patterns of SNPs to complex and omics traits. In gene regions harboring known susceptibility loci, Primo performs conditional association analysis to account for linkage disequilibrium. Primo allows for unknown study heterogeneity and sample correlations. We show two applications using Primo to examine the molecular mechanisms of known susceptibility loci and to detect and interpret pleiotropic effects.

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