scholarly journals ROLE OF MESENCHYMAL STEM CELLS IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (REVIEW)

2018 ◽  
Vol 1 (70) ◽  
pp. 121-128
Author(s):  
Сергей Целуйко ◽  
Sergey Tseluyko ◽  
А Яценко ◽  
A Yacenko ◽  
Е Устинов ◽  
...  

Current methods of treatment of chronic obstructive pulmonary disease are not effective enough and lead to the progression of the disease and disability of the patient. One of the promising methods of chronic obstructive pulmonary disease therapy is the use of the possibilities of regenerative medicine, in particular, mesenchymal stem cells. The review demonstrates the achievements of research groups developing approaches to chronic obstructive pulmonary disease therapy based on mesenchymal stem cells. Our attention was focused on the problems and possible ways to show the mechanism of action of mesenchymal stem cells. The issues of safety of mesenchymal stem cells application are also discussed.

2018 ◽  
Vol 15 (5) ◽  
pp. 536-556 ◽  
Author(s):  
Irene Coppolino ◽  
Paolo Ruggeri ◽  
Francesco Nucera ◽  
Mario Francesco Cannavò ◽  
Ian Adcock ◽  
...  

2018 ◽  
Vol 15 (6) ◽  
pp. 65-78
Author(s):  
G B Fedoseev ◽  
V I Trofimov ◽  
V I Golubeva ◽  
V G Timchik ◽  
K V Negrutsa ◽  
...  

The article deals with bacterial lung microbiota in patients with bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD), bacterial inflammation of the bronchopulmonary system which can be manifested by sensitization and allergy. Also they can be a trigger with the development of bacterial inflammation. Bacteria can colonize the lungs without severe clinical, laboratory and instrumental changes. High levels of IgG to Str. pneumoniae, Neisseria perflava, Haemophilus influenza in ACOS patients can be evidence of their etiological significance. Taking into account the etiological significance of microbiota, methods of treatment of patients with COPD and BA with the use of antibiotics, vaccines and probiotics have been developed.


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