scholarly journals About the role of bacteria in patients with bronchial asthma, chronic obstructive pulmonary disease and ACOS

2018 ◽  
Vol 15 (6) ◽  
pp. 65-78
Author(s):  
G B Fedoseev ◽  
V I Trofimov ◽  
V I Golubeva ◽  
V G Timchik ◽  
K V Negrutsa ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Bronchial Asthma ◽  
Clinical Laboratory ◽  
Chronic Obstructive ◽  
Haemophilus Influenza ◽  
Obstructive Pulmonary Disease ◽  
Neisseria Perflava ◽  
Methods Of Treatment

The article deals with bacterial lung microbiota in patients with bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD), bacterial inflammation of the bronchopulmonary system which can be manifested by sensitization and allergy. Also they can be a trigger with the development of bacterial inflammation. Bacteria can colonize the lungs without severe clinical, laboratory and instrumental changes. High levels of IgG to Str. pneumoniae, Neisseria perflava, Haemophilus influenza in ACOS patients can be evidence of their etiological significance. Taking into account the etiological significance of microbiota, methods of treatment of patients with COPD and BA with the use of antibiotics, vaccines and probiotics have been developed.

The role of leukotrienes in the pathogenesis of inflammation in patients with different phenotypes of bronchial asthma and chronic obstructive pulmonary disease

Pharmateca ◽  
2020 ◽  
Vol 10_2020 ◽  
pp. 88-93
Author(s):  
E.M. Kostina Kostina ◽  
E.Yu. Trushina Trushina ◽  
E.A. Orlova Orlova ◽  
N.I. Baranova Baranova ◽  
O.A. Levashova Levashova ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Bronchial Asthma ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals THE FUNCTIONAL STATUS OF NEUTROPHILS IN PATIENTS WITH BRONCHIAL ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, BRONCHIAL ASTHMA IN COMBINATION WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND COMMUNITY-ACOUIRED PNEUMONIA

2017 ◽  
Vol 14 (6) ◽  
pp. 43-58
Author(s):  
G B Fedoseev ◽  
V I Trofimov ◽  
K V Negrutsa ◽  
V G Tymchyk ◽  
V I Golubeva ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Bronchial Asthma ◽  
Community Acquired Pneumonia ◽  
Control Group ◽  
Chronic Obstructive ◽  
Bronchial Obstruction ◽  
Obstructive Pulmonary Disease ◽  
Oxygen Blast ◽  
Neisseria Perflava

217 people were examined including BA patients (n=78), patients with COPD (n=38), patients with combined asthma and COPD (n=39), and community-acquired pneumonia patients (n=17). The control group represented patients with essential hypertension and coronary heart disease (n=25) and 20 healthy persons. NE, AAT, phagocytic activity of neutrophils (FGC), oxygen blast, respiratory function and FeNO, serum IgE and IgG antibodies to Strept. pneumoniae, Neisseria perflava, Haemofil. influenzae and Staph. aigai were determined in all patients. The indicators of the functional state of neutrophils reflected the degree and severity of bronchopulmonary inflammation. Patients with bronchial asthma in combination with COPD had bacterial inflammation, manifested by bronchial obstruction with increasing level of AAT. These features were absent in patients with BA and COPD.

scholarly journals ROLE OF MESENCHYMAL STEM CELLS IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (REVIEW)

2018 ◽  
Vol 1 (70) ◽  
pp. 121-128
Author(s):  
Сергей Целуйко ◽  
Sergey Tseluyko ◽  
А Яценко ◽  
A Yacenko ◽  
Е Устинов ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Research Groups ◽  
Obstructive Pulmonary Disease ◽  
Disease Therapy ◽  
Methods Of Treatment

Current methods of treatment of chronic obstructive pulmonary disease are not effective enough and lead to the progression of the disease and disability of the patient. One of the promising methods of chronic obstructive pulmonary disease therapy is the use of the possibilities of regenerative medicine, in particular, mesenchymal stem cells. The review demonstrates the achievements of research groups developing approaches to chronic obstructive pulmonary disease therapy based on mesenchymal stem cells. Our attention was focused on the problems and possible ways to show the mechanism of action of mesenchymal stem cells. The issues of safety of mesenchymal stem cells application are also discussed.

Role of exhaled nitric oxide in predicting steroid response in chronic obstructive pulmonary disease

2010 ◽  
Vol 151 (51) ◽  
pp. 2083-2088 ◽  
Author(s):  
Balázs Antus
Keyword(s):  
Nitric Oxide ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Exhaled Nitric Oxide ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Steroid Response

A kilégzett levegőben mérhető nitrogén-monoxid a legszélesebb körben vizsgált légúti biomarker. A stabil állapotú krónikus obstruktív tüdőbetegségben a kilégzett nitrogén-monoxid-szint hasonló vagy csak kismértékben emelkedett az egészségesekhez képest. Mivel a nitrogén-monoxid-szint szoros összefüggést mutat a légúti eosinophilia mértékével, és mivel az eosinophil típusú légúti gyulladás szteroidokra érzékenyebb, az emelkedett nitrogén-monoxid-szinttel rendelkező betegek jobb válaszkészséget mutatnak az inhalációs vagy szisztémás kortikoszteroidkezelésre. A krónikus obstruktív tüdőbetegség akut exacerbatiója során a kilégzett nitrogén-monoxid szintje megemelkedik, majd ennek kezelése után csökken. Mivel a nitrogén-monoxid-szint és a kezelés során elért légzésfunkciós javulás szoros korrelációt mutat egymással, a nitrogén-monoxid-méréssel a terápiás válasz megjósolható. Összefoglalva: a nitrogén-monoxid-méréssel a krónikus obstruktív tüdőbetegségben szenvedő betegek olyan alcsoportját lehet elkülöníteni, amelynek szteroidérzékenysége nagyobb. Orv. Hetil., 2010, 151, 2083–2088.

Participation of ABCA1 transporter in development of chronic obstructive pulmonary disease

2020 ◽  
Vol 28 (3) ◽  
pp. 360-370
Author(s):  
Stanislav N. Kotlyarov ◽  
Anna A. Kotlyarova
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Significant Contribution ◽  
Modern Medicine ◽  
Lipid Homeostasis ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Reverse Transport ◽  
Current Paradigm

Despite all achievements of the modern medicine, the problem of chronic obstructive pulmonary disease (COPD) does not lose its relevance. The current paradigm suggests a key role of macrophages in inflammation in COPD. Macrophages are known to be heterogeneous in their functions. This heterogeneity is determined by their immunometabolic profile and also by peculiarities of lipid homeostasis of cells. Aim. To analyze the role of the ABCA1 transporter, a member of the ABC A subfamily, in the pathogenesis of COPD. The expression of ABCA1 in lung tissues is on the second place after the liver, which shows the important role of the carrier and of lipid homeostasis in the function of lungs. Analysis of the literature shows that participation of the transporter in inflammation consists in regulation of the content of cholesterol in the lipid rafts of the membranes, in phagocytosis and apoptosis. Conclusion. Through regulation of the process of reverse transport of cholesterol in macrophages of lungs, ABCA1 can change their inflammatory response, which makes a significant contribution to the pathogenesis of COPD.

Clinical and functional peculiarities at patients with bronchial asthma, chronic obstructive pulmonary disease and overlap of asthma-chronic obstructive pulmonary disease

2020 ◽  
Vol 24 (4) ◽  
pp. 80-86
Author(s):  
V. I. Trofimov ◽  
D. Z. Baranov
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Bronchial Asthma ◽  
Blood Test ◽  
Chronic Obstructive ◽  
Inflammation Markers ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Functional Features ◽  
Lower Airways

BACKGROUND: a comparative analysis of laboratory and instrumental tests at patients with bronchial obstructive diseases seems very actual due to the wide prevalence of these diseases. THE AIM: to evaluate characteristics of spirometry as well as allergic (total IgE, sputum eosinophils) and infectious (blood and sputum leucocytes, ESR, CRP, fibrinogen) inflammation markers at patients with bronchial obstructive diseases. PATIENTS AND METHODS: 104 case histories of patients with bronchial asthma, chronic obstructive pulmonary disease and overlap were analyzed including age, duration of smoking (pack-years), laboratory (clinical blood test, biochemical blood test, general sputum analysis, sputum culture) and instrumental (spirometry, body plethysmography, echocardiography) tests. Data were processed statistically with non-parametric methods. RESULTS: COPD patients were older than other groups’ patients, had the highest pack-years index. ACO patients were marked with maximal TLC and Raw, minimal FEV1, FEF25-75, FEV1/FVC. Patients with COPD had the highest inflammation markers (leucocyte count, CRP, fibrinogen). CONCLUSION: high active inflammation may cause severe lower airways possibility disorders at patients with COPD. Data related to a possible role of K. pneumoniaе in the pathogenesis of eosinophilic inflammation in lower airways are of significant interest. Patients with ACO occupy an intermediate position between asthma and COPD patients based on clinical and functional features.

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