scholarly journals Rat skin inflammation markers change in response to calcium hydroxyapatite and hyaluronic acid administration

2021 ◽  
Vol 11 (8) ◽  
pp. 510-519
Author(s):  
S. Larkina ◽  
A. Seletskaya ◽  
O. Makarenko ◽  
R. Vastyanov
Keyword(s):  
Hyaluronic Acid ◽  
Acid Phosphatase ◽  
Calcium Hydroxyapatite ◽  
Skin Inflammation ◽  
Molecular Response ◽  
Inflammation Markers ◽  
Laboratory Rats ◽  
Markers Of Inflammation ◽  
Mda Content ◽  
Acid Administration

In the research, the level of some markers of skin inflammation in Wistar rats was examined after injection of calcium hydroxyapatite and hyaluronic acid drugs of various concentrations, where the nature, degree, extent of tissue damage and the general condition of the animals in general were close to humans’. Each drug was evaluated according to several indicators (MDA content, activity of neutrophil elastase, acid phosphatase, and catalase) to understand the measure of the adequacy of the body's response to the intensity of the stimulus. A biochemical analysis of the skin of laboratory rats after the injection of the studied drugs showed that the safest drugs contain nonstabilized 4% hyaluronic acid. Either in pure form or in a 1: 1 mixture with calcium hydroxyapatite at a concentration of 55.7%, since in 2 months after their injection in the skin of experimental animals, markers of inflammation (elastase, acid phosphatase and MDA levels), catalase and API activity were found at the normal level. The injection of drugs containing stabilized 2% hyaluronic acid and calcium hydroxyapatite 55.7%, as well as stabilized 2.6% hyaluronic acid and calcium hydroxyapatite at a concentration of 1% caused prolonged LPO activation, increased level of inflammation markers and decreased API. The injection of calcium hydroxyapatite drugs without hyaluronic acid, even at a 1: 1 dilution with saline, also caused prolonged LPO activation, an increased level of inflammation markers and a decreased API, and, in addition, revealed a significant increase in acid phosphatase activity, which is an indicator of the integrity of cell membranes. The obtained results made it possible to analyze the features of the molecular response and regulation of inflammation upon injection of calcium hydroxyapatite and hyaluronic acid drugs of different concentrations, which will help in prescribing of treatment.

EFFECT OF CALCIUM HYDROXYAPATITE AND HYALURONIC ACID INJECTIONS ON INFLAMMATION MARKERS OF PERIODONT TISSUE

2021 ◽  
Vol 17 (77) ◽  
pp. 224
Author(s):  
S. A. Larkina ◽  
А. V. Seletskaya ◽  
O. А. Makarenko ◽  
S. A. Schneider
Keyword(s):  
Hyaluronic Acid ◽  
Calcium Hydroxyapatite ◽  
Inflammation Markers

scholarly journals Potential Biological Markers of Atrial Fibrillation: A Chance to Prevent Cryptogenic Stroke

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
István Szegedi ◽  
László Szapáry ◽  
Péter Csécsei ◽  
Zoltán Csanádi ◽  
László Csiba
Keyword(s):  
Atrial Fibrillation ◽  
Biological Markers ◽  
Cryptogenic Stroke ◽  
Biological Marker ◽  
Ecg Monitoring ◽  
Inflammation Markers ◽  
Good Patient ◽  
Markers Of Inflammation ◽  
Good Patient Compliance ◽  
And Function

Stroke affects millions of people all over the world, causing death and disability. The most frequent type of this disease is ischemic stroke, which can be caused by different factors. In approximately 25 percent of cases, no obvious cause can be found. Recent observations have shown that paroxysmal atrial fibrillation could be responsible for a significant number of cryptogenic stroke events. Short- or long-lasting ECG monitoring could help with the diagnosis of transient arrhythmias. Unfortunately, these techniques either are expensive or require good patient compliance. An alternative option is the identification of biological markers that are specific for atrial fibrillation and can be used to predict arrhythmia. In this review, we give a summary of the recent advances in the research of arrhythmia markers. Based on their structure and function, we differentiated four groups of biomarkers: markers of inflammation, markers of fibrosis, markers with hormonal activity, and other markers. In spite of intensive researches, the optimal biological marker is still not available, but there are some promising markers, like NT-proBNP/BNP.

scholarly journals Fillers and Vessels: The Story of Arterial Obstruction after Cosmetic Treatment

2021 ◽  
Vol 6 (2) ◽  
pp. 1-4
Author(s):  
Velthuis PJ
Keyword(s):  
Hyaluronic Acid ◽  
Skin Necrosis ◽  
Ultrasound Guidance ◽  
Arterial Occlusion ◽  
Calcium Hydroxyapatite ◽  
Duplex Sonography ◽  
Low Grade ◽  
Filler Injection ◽  
Retinal Artery ◽  
Cosmetic Medicine

Most popular fillers in cosmetic medicine are hyaluronic acid based. These comprise over 90% of the market and come with the advantage to be soluble in case of complications. Other fillers are contained in the group of bio-stimulatory fillers. They exert a secondary volumizing effect by provoking a low-grade inflammatory response that produces extra collagen. Examples are calcium-hydroxyapatite and L-poly-lactid acid. Finally autologous fat is being used as a filling substance (lipofilling). The gravest complications with fillers are intravascular injections. In particular when injected in arteries fillers can block blood flow and lead to skin necrosis or vison loss in case the material occludes the Central Retinal Artery (CRAO). Two opposing theories about the nature of arterial occlusion exist. One based on Ian Taylor idea of choke anastomoses assume vasoconstriction induced by the filler, both of the primary offended artery and its anastomosing vasosomes. In this case resolving the hyaluronic acid filler with the enzyme hyaluronidase at the primary occluding location would suffice. This is done under ultrasound guidance. The other theory assumes displacement of parts of the filler to end arterioles. Then, the whole affected area has to be flooded with large dosages of hyaluronidase. Obstructions with fillers based on other materials cannot be resolved. It seems logical to prevent intra-arterial filler injection by duplex sonography detection of the course of arteries prior to injection. Ultrasound has additional advantages for cosmetic doctors such as recognizing remains of previously injected filler. It also can give feedback on a physician’s ability to inject filler in the correct subdermal location.

scholarly journals A woman with purple toes after intrarticular hyaluronic acid administration

2017 ◽  
Vol 49 (2) ◽  
pp. 47
Author(s):  
Valentina Broshtilova ◽  
Dimitar Nikolov ◽  
Filka Georgieva ◽  
Sonya Marina
Keyword(s):  
Hyaluronic Acid ◽  
Acid Administration

scholarly journals M62. PERIPHERAL INFLAMMATION MARKERS IDENTIFY SUBSET OF PATIENTS WITH SCHIZOPHRENIA AND RELATED PSYCHOSES WHO HAVE INTELLECTUAL DECLINE FROM PREMORBID LEVELS

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S158-S159
Author(s):  
Thomas Weickert ◽  
Seetha Ramanathan ◽  
Rhoshel Lenroot ◽  
Dennis Liu ◽  
Ryan Balzan ◽  
...  
Keyword(s):  
Venous Blood ◽  
Chronically Ill ◽  
Cutoff Score ◽  
Peripheral Inflammation ◽  
Healthy Controls ◽  
Inflammation Markers ◽  
Significant Drop ◽  
Illness Onset ◽  
Markers Of Inflammation ◽  
Chronically Ill Patients

Abstract Background Higher inflammation has been identified in a substantial subset of both high-risk and chronically ill patients with schizophrenia and related psychoses and this may account for some of the heterogeneity of the schizophrenia. There is also much heterogeneity in cognitive deficits related to schizophrenia with some patients showing a marked decline from premorbid intellectual levels while others show little change from either normal or low intellect. However, the relationship between intellectual change with the illness onset and inflammation in schizophrenia has not been established. Methods Here, we report the assessment of two common markers of inflammation from two independent samples of generally chronically ill patients with schizophrenia and related psychoses (one sample of 73 patients versus 70 healthy controls from Sydney, NSW, Australia and one sample of 297 patients from Syracuse, NY, USA). Peripheral venous blood samples were collected from all patients and blood markers of inflammation (C-Reactive Protein, CRP, and Neutrophil to Lymphocyte Ratio, NLR) were assayed using standard procedures. Assessment of premorbid and current intellectual abilities were obtained from the Sydney cohort of patients. Results Grouping the patients and controls from the Sydney sample into those with elevated (> 3 mg/L) versus normal (< 3 mg/L) CRP levels revealed 42% of the patients versus 20% of the healthy controls had elevated CRP (Chi Square = 9.16, p = .002) and further evidence of inflammation with an elevated mean NLR of 2.5. The frequency of peripheral inflammation was confirmed by the independent sample from Syracuse in which 39% of the patients (n= 115) had an elevated NLR above a cutoff score for normal of 2.2 which was consistent with the Sydney sample. Patients from the Sydney sample who had an elevated CRP also had a significant mean 15-point IQ decline from premorbid IQ levels, whereas the patients with CRP levels within normal limits did not show a statistically significant drop in IQ from premorbid levels (mean IQ decline 7.6 points). Healthy controls with normal CRP had no IQ change (0.0 points) and healthy controls with elevated CRP has a slight, non-significant IQ decline (mean 2.3 points). Discussion Thus, our study showed supportive evidence of elevated peripheral inflammation markers in subgroups of chronically ill patients with schizophrenia from two independent samples and a link between marked intellectual decline from premorbid levels and current peripheral inflammation in one chronically ill subgroup of patients with schizophrenia suggesting a role for inflammation in the cognitive impairment of a substantial proportion (40%) of patients with schizophrenia.

scholarly journals A Comparison of Calcium Hydroxyapatite and Dextranomer/Hyaluronic Acid for the Endoscopic Treatment of Vesicoureteral Reflux

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Tin C. Ngo ◽  
Ilene Yi-Zhen Wong ◽  
William A. Kennedy
Keyword(s):  
Hyaluronic Acid ◽  
Learning Curve ◽  
Success Rate ◽  
Endoscopic Treatment ◽  
Single Injection ◽  
Statistical Significance ◽  
Case Series ◽  
Calcium Hydroxyapatite ◽  
Success Rates ◽  
Single User

Purpose. Minimal data exists comparing dextranomer/hyaluronic acid (Dx/HA) and calcium hydroxyapatite (CaHA) for the endoscopic treatment of VUR in the hands of a single user.Materials and Methods. We reviewed our consecutive single-user case series of 27 children (42 ureters) receiving endoscopic treatment with CaHA and 21 children (33 ureters) who received Dx/HA injection. Children receiving CaHA injections were divided into two groups of 13 and 14 patients (Coaptite I and II) to assess the learning curve effects. Postoperatively, RBUS and VCUG were performed. Multiple regression analysis was performed to assess statistical significance of success rates.Results. The total CaHA group had a per-ureter success rate (Grade 0) of 52% after one injection. When separated into two cohorts, the single injection per-ureter success rates were 43% for Coaptite I and 62% for Coaptite II. In contrast, the Dx/HA series had a single injection per-ureter success rate (Grade 0) of 78%.Conclusions. Our consecutive case experience shows improved results for Dx/HA compared to CaHA, though the learning curve effects and evolution of injection technique likely played a role in the improved outcomes in the Dx/HA cohort. A randomized controlled multicenter trial would provide the most accurate data comparing these two agents.

scholarly journals Clinical Value of Concentrations of Inflammation Immunochemical Markers in Blood Serum in Children with Viral Meningitis

2021 ◽  
Vol 65 (6) ◽  
pp. 50-56
Author(s):  
O. G. Kimirilova ◽  
G. A. Kharchenko
Keyword(s):  
Blood Serum ◽  
Ferritin Level ◽  
Viral Meningitis ◽  
Inflammation Markers ◽  
Clinical Value ◽  
Severity Level ◽  
Markers Of Inflammation

A number of the immunochemical markers of inflammation in the blood serum, such as the lactoferrin, transferrin, ferritin, and fibrinogen were identified in 450 patients with the viral meningitis of various etiologies (enterovirus, arbovirus, mumps, adenovirus, and herpesvirus) at 14 years of age. The imbalance of the inflammation markers identified was determined, the severity of which depended on the severity, course and outcome of the disease. The decrease of the lactoferrin concentration by 29% (from 719 to 516 ng/ml) and increase of the ferritin level by 30% (from 70 to 91 ng/ml) by the period of the early convalescence met the heavy severity level of the meningitis. The decrease of the lactoferrin concentration by 2% (from 785 to 770 ng/ml) and increase of the ferritin level by 45% (from 68 to 99 ng/ l) by the period of early convalescence indicated the lingering course of the disease. The concentrations of the transferrin less than 2 g/l (1.74 to 1.68 g/l) and ferritin less than 50 ng/ml (40 to 48 ng/ml) were unfavorable prognosis of for the meningitis outcome.

scholarly journals Correction of volumetric aging of hands: comparative study between calcium hydroxyapatite and hyaluronic acid

2017 ◽  
Vol 9 (4) ◽  
Author(s):  
Guilherme Bueno de Oliveira ◽  
Natália Cristina Rossi Bueno de Oliveira ◽  
Bárbara Maria Tarraf Moreira ◽  
Marcela Ferraz Awada ◽  
Vitória Carneiro Assunção Zerati
Keyword(s):  
Hyaluronic Acid ◽  
Comparative Study ◽  
Calcium Hydroxyapatite
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