Biochemical Markers as Indicators of Lung Injury in Conventional Tidal Volume Ventilation versus Low Tidal Volume Ventilation in Mechanically Ventilated Patients without Acute Lung Injury

2013 ◽  
Vol 24 (3) ◽  
pp. 207-216
Author(s):  
A. A. Khattab ◽  
Dalia G. Amine
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tidal Volume ◽  
Biochemical Markers ◽  
Mechanically Ventilated ◽  
Mechanically Ventilated Patients ◽  
Low Tidal Volume ◽  
Low Tidal Volume Ventilation ◽  
Volume Ventilation ◽  
Ventilated Patients

scholarly journals Management of hypercapnia in critically ill mechanically ventilated patients—A narrative review of literature

2020 ◽  
Vol 21 (4) ◽  
pp. 327-333
Author(s):  
Ravindranath Tiruvoipati ◽  
Sachin Gupta ◽  
David Pilcher ◽  
Michael Bailey
Keyword(s):  
Mechanical Ventilation ◽  
Tidal Volume ◽  
Dead Space ◽  
Hypercapnic Acidosis ◽  
Mechanically Ventilated ◽  
Mechanically Ventilated Patients ◽  
Low Tidal Volume ◽  
Volume Ventilation ◽  
Low Volume ◽  
Ventilated Patients

The use of lower tidal volume ventilation was shown to improve survival in mechanically ventilated patients with acute lung injury. In some patients this strategy may cause hypercapnic acidosis. A significant body of recent clinical data suggest that hypercapnic acidosis is associated with adverse clinical outcomes including increased hospital mortality. We aimed to review the available treatment options that may be used to manage acute hypercapnic acidosis that may be seen with low tidal volume ventilation. The databases of MEDLINE and EMBASE were searched. Studies including animals or tissues were excluded. We also searched bibliographic references of relevant studies, irrespective of study design with the intention of finding relevant studies to be included in this review. The possible options to treat hypercapnia included optimising the use of low tidal volume mechanical ventilation to enhance carbon dioxide elimination. These include techniques to reduce dead space ventilation, and physiological dead space, use of buffers, airway pressure release ventilation and prone positon ventilation. In patients where hypercapnic acidosis could not be managed with lung protective mechanical ventilation, extracorporeal techniques may be used. Newer, minimally invasive low volume venovenous extracorporeal devices are currently being investigated for managing hypercapnia associated with low and ultra-low volume mechanical ventilation.

Low tidal volume ventilation does not increase sedation use in patients with acute lung injury*

2005 ◽  
Vol 33 (4) ◽  
pp. 766-771 ◽  
Author(s):  
Jeremy M. Kahn ◽  
Liane Andersson ◽  
Veena Karir ◽  
Nayak L. Polissar ◽  
Margaret J. Neff ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tidal Volume ◽  
Low Tidal Volume ◽  
Low Tidal Volume Ventilation ◽  
Volume Ventilation

Low tidal volume ventilation preconditioning ameliorates lipopolysaccharide-induced acute lung injury in rats

2016 ◽  
Vol 60 (6) ◽  
pp. 780-789 ◽  
Author(s):  
Y. Zhang ◽  
J. Gao ◽  
C.-J. Wang ◽  
L.-J. Zhou ◽  
X.-Z. Fang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tidal Volume ◽  
Low Tidal Volume ◽  
Low Tidal Volume Ventilation ◽  
Volume Ventilation
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