Collagen stimulants in facial rejuvenation: a systematic review

Collagen-stimulating agents relating to facial rejuvenation are part of the family of soft tissue fillers that can be used for facial contouring, volume restoration and skin rejuvenation through bio-stimulation of the tissues ( Strawford, 2020 ). Radiesse®, made from calcium hydroxylapatite, was US Food and Drug Adminstration-approved in 2006. Ellansé®, made from polycaprolactone, was CE-approved in 2009. However, polycaprolactone (which makes up 70% of Ellansé®) has been an FDA-approved biomaterial since 2001 ( Christen and Vercesi, 2020 ). This systematic review will evaluate the available evidence and evaluate if it continues to support the safety and efficacy of these two facial collagen stimulating materials.