scholarly journals Virilizing Adrenocortical Carcinoma Invading the Right Atrium with Histological High-Grade Malignancy and p53 Mutation in a 3-Year-Old Child: Indication of Post Operative Adjuvant Chemotherapy

2004 ◽  
Vol 13 (1) ◽  
pp. 25-32 ◽  
Author(s):  
Keisuke Nagasaki ◽  
Reiko Horikawa ◽  
Jun-ichi Nagaishi ◽  
Toshiro Honna ◽  
Akihiko Sekiguchi ◽  
...  
Keyword(s):  
Adjuvant Chemotherapy ◽  
Adrenocortical Carcinoma ◽  
Right Atrium ◽  
P53 Mutation ◽  
High Grade ◽  
Grade Malignancy ◽  
The Right ◽  
High Grade Malignancy

scholarly journals Unusual biological behavior of femoral liposarcoma

2007 ◽  
Vol 135 (7-8) ◽  
pp. 468-471 ◽  
Author(s):  
Milan Stojanovic ◽  
Branislav Goldner ◽  
Spasenija Djukic
Keyword(s):  
Biological Behavior ◽  
Low Grade ◽  
High Grade ◽  
Therapeutic Protocol ◽  
Grade Of Malignancy ◽  
Males And Females ◽  
Grade Malignancy ◽  
The Right ◽  
High Grade Malignancy ◽  
Scapular Region

Introduction Liposarcoma of a bone is a very rare tumor of the fatty marrow, originating from lipoblasts. Its frequency is 1:1000 of all bone tumors. The long bones and the lower extremities are predominantly affected, equally in males and females between 30 and 70 years of age. In the estimation of its biological behavior, histological graduation (G), the surgical localization of the tumor (T) and the presence or absence of metastases (M), are very important. A tumor with low grade differentiation, with transosseal propagation and metastases, has a poor prognosis. Surgical resection-amputation, chemotherapy and radiotherapy are the therapeutic methods of choice. Case outline Twelve years ago, in a 58-year old man, there was a radiologically diagnosed sarcoma in the lower part of the right femur manifested with painful swelling in that region. The high suprapatellar amputation was done. There was a histologically proved liposarcoma of a high grade of malignancy. According to the therapeutic protocol, chemotherapy and radiotherapy were applied. During the period of 12 years, the patient had a relapse on the stump, metastatic dissemination in the soft tissue of small pelvis twice, once in the left scapular region and in the inguinal lymph nodes, six operations and 8-year accumulation of metastatic deposits in the lung. Now, the patient feels relatively well, mobile, and walks 5 kilometres every day. Conclusion Unusual behaviour of the liposarcoma of high grade malignancy with which the patient has been living for 12 years, could be explained by the patient?s strong immunobiological system in the struggle to retain its vitality and mobility.

scholarly journals Olfactory Preservation in Craniofacial Resection of Tumor Invading Hemianterior Skull Base: Operative Video

2021 ◽  
Author(s):  
Kenya Kobayashi ◽  
Yasuji Miyakita ◽  
Fumihiko Matsumoto ◽  
Go Omura ◽  
Satoko Matsumura ◽  
...  
Keyword(s):  
Skull Base ◽  
Nasal Septum ◽  
Cribriform Plate ◽  
Cerebrospinal Fluid Leakage ◽  
Low Grade ◽  
High Grade ◽  
Craniofacial Resection ◽  
Grade Malignancy ◽  
The Right ◽  
High Grade Malignancy

AbstractIn traditional craniofacial resection of tumors invading the anterior skull base, the bilateral olfactory apparatus is resected. Recently, transnasal endoscopy has been used for olfactory preservation in resections of unilateral low-grade malignancies. However, for tumors that invade the orbita or for high-grade malignancies, the transnasal endoscopic skull base surgery has been controversial. This video demonstrates the surgical techniques of olfactory preservation during craniofacial resection of a high-grade malignancy invading the hemianterior skull base and orbita.We present the case of a 32-year-old woman with osteosarcoma in the right ethmoid sinus. The tumor invaded the ipsilateral cribriform plate, dura menta, and orbital periosteum; however, the nasal septum and crista galli were intact (Fig. 1A, B). Because the tumor was a high-grade malignancy and the orbita had been invaded, we performed craniofacial resection instead of endoscopic resection (Fig. C2A). We drilled into the right side of the crista galli, midline of the cribriform plate, and perpendicular plate of the ethmoid bone via craniotomy. As a result, we accessed the nasal cavity directly (Fig. 2B). To preserve the nasal septum, we detached the remaining right septal mucosa through the transfacial approach (Fig. 2C). Because of the high risk of cerebrospinal fluid leakage as a result of previous irradiation, we performed vascularized free flap reconstruction of the skull base instead of pericranial flap.Postoperative computed tomography revealed no evidence of tumor (Fig. 1C, D). The patient's sense of smell returned after 1 postoperative day, and she was discharged on the postoperative day 14.The link to the video can be found at: https://youtu.be/XzPABYwzkjs.

High-grade angiosarcoma of the right atrium successfully targeted with total resection and reconstruction followed by adjuvant chemotherapy

2014 ◽  
Author(s):  
Joost S. Vermaat ◽  
Alaaddin Yilmaz ◽  
Peter C. de Bruin ◽  
H. Wouter van Es ◽  
Martijn C. Post
Keyword(s):  
Adjuvant Chemotherapy ◽  
Right Atrium ◽  
High Grade ◽  
Total Resection ◽  
The Right

Low-grade malignant perineurioma of the paravertebral column, transforming into a high-grade malignancy

1999 ◽  
Vol 49 (9) ◽  
pp. 820-825 ◽  
Author(s):  
Shino Karaki ◽  
Joji Mochida ◽  
Yoon Hwan Lee ◽  
Kazuhiro Nishimura ◽  
Yutaka Tsutsumi
Keyword(s):  
Low Grade ◽  
High Grade ◽  
Grade Malignancy ◽  
High Grade Malignancy

scholarly journals RESECTION OF ESOPHAGEAL GASTROINTESTINAL STROMAL TUMOR WITH HIGH-GRADE MALIGNANCY-A CASE REPORT-

2006 ◽  
Vol 67 (7) ◽  
pp. 1541-1545 ◽  
Author(s):  
Hisashi ISHIKURA ◽  
Hiroshi OKITSU ◽  
Akihiro SAKATA ◽  
Masashi ISHIKAWA ◽  
Jyunnichi SEIKE ◽  
...  
Keyword(s):  
Case Report ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
High Grade ◽  
Grade Malignancy ◽  
High Grade Malignancy

scholarly journals Functioning Adrenocortical Carcinoma with Extension upto the Right Atrium Producing Cushing's Syndrome

2013 ◽  
Vol 3 ◽  
pp. 32 ◽  
Author(s):  
Santosh Kumar ◽  
Gautam R. Choudhary ◽  
Arawat Pushkarna
Keyword(s):  
Inferior Vena Cava ◽  
Cushing’S Syndrome ◽  
Adrenocortical Carcinoma ◽  
Right Atrium ◽  
Inferior Vena ◽  
Vena Cava ◽  
Cushing's Syndrome ◽  
Curative Therapy ◽  
Rare Malignancy ◽  
The Right

Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. Surgery is the only curative therapy available and overall 5-year survival for patients who undergo a complete resection is 32% to 48%. They are known to produce intravascular invasion and into the inferior vena cava (IVC) and in rare cases they may reach the right atrium. We report a case of functioning ACC extending into the inferior vena cava and right atrium in a female with Cushing's syndrome.

scholarly journals Musculoskeletal oncology: patient triage and management during the COVID-19 pandemic

2020 ◽  
Vol 27 (5) ◽  
Author(s):  
N. Olshinka ◽  
S. Mottard
Keyword(s):  
Surgical Oncology ◽  
Low Grade ◽  
High Grade ◽  
Oncology Patient ◽  
Exposure Risks ◽  
Grade Malignancy ◽  
Oncology Centre ◽  
Sarcoma Treatment ◽  
Musculoskeletal Oncology ◽  
High Grade Malignancy

Sarcoma treatment during the covid-19 pandemic is a new challenge. This patient population is often immunocom­promised and potentially more susceptible to viral complications.    Government guidelines highlight the need to minimize patient exposure to unnecessary hospital visits. However, those guidelines lack practical recommendations on ways to manage triage and diagnosis expressly for new cancer patients. Furthermore, there are no reports on the efficiency of the guidelines.    One of the main issues in treating musculoskeletal tumours is the complexity and variability of presentation. We offer a triage model, used in a quaternary-referral musculoskeletal oncology centre, that allows us to maintain an open pathway for referral of new patients while minimizing exposure risks. A multidisciplinary approach and analysis of existing investigations allow for a pre-clinic evaluation.    The model identifies 3 groups of patients: Patients with suspected high-grade malignancy, or benign cases with aggressive features, both in need of further evaluation in the clinic and prompt treatment Patients with low-grade malignancy, and benign cases whose treatment is not urgent, that are managed, during the pandemic by telemedicine, with reassurance and information about their illness Patients who can be managed by their local medical professionals    In comparison to a pre-pandemic period, that approach resulted in a higher ratio of malignant-to-benign con­ditions for new patients seen in the clinic (3:4 vs. 1:3 respectively), thus using available resources more efficiently and prioritizing patients with suspected high-grade malignancy.    We believe that this triage system could be applied in other surgical oncology fields during a pandemic.

L-TYPE AMINO ACID TRANSPORTER 1 EXPRESSION IN PROSTATE CANCER: ASSOCIATION WITH CANCER PROGRESSION AND HIGH-GRADE MALIGNANCY

2008 ◽  
Vol 179 (4S) ◽  
pp. 105-105
Author(s):  
Takefumi Satoh ◽  
Takeshi Sakata ◽  
Isao Okayasu ◽  
Golam Ferdous ◽  
Tomoko Tsuruta ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Amino Acid ◽  
Cancer Progression ◽  
Amino Acid Transporter ◽  
High Grade ◽  
Acid Transporter ◽  
Grade Malignancy ◽  
High Grade Malignancy
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