Faculty Opinions recommendation of RET oncogene amplification in thyroid cancer: correlations with radiation-associated and high-grade malignancy.

Author(s):  
Gilbert Cote
2007 ◽  
Vol 38 (4) ◽  
pp. 621-628 ◽  
Author(s):  
Masahiro Nakashima ◽  
Noboru Takamura ◽  
Hiroyuki Namba ◽  
Vladimir Saenko ◽  
Serik Meirmanov ◽  
...  

2007 ◽  
Vol 1299 ◽  
pp. 251-255
Author(s):  
Masahiro Nakashima ◽  
Noboru Takamura ◽  
Hiroyuki Namba ◽  
Vladimir A. Saenko ◽  
Keiji Suzuki ◽  
...  

1999 ◽  
Vol 49 (9) ◽  
pp. 820-825 ◽  
Author(s):  
Shino Karaki ◽  
Joji Mochida ◽  
Yoon Hwan Lee ◽  
Kazuhiro Nishimura ◽  
Yutaka Tsutsumi

2006 ◽  
Vol 67 (7) ◽  
pp. 1541-1545 ◽  
Author(s):  
Hisashi ISHIKURA ◽  
Hiroshi OKITSU ◽  
Akihiro SAKATA ◽  
Masashi ISHIKAWA ◽  
Jyunnichi SEIKE ◽  
...  

2020 ◽  
Vol 27 (5) ◽  
Author(s):  
N. Olshinka ◽  
S. Mottard

Sarcoma treatment during the covid-19 pandemic is a new challenge. This patient population is often immunocom­promised and potentially more susceptible to viral complications.    Government guidelines highlight the need to minimize patient exposure to unnecessary hospital visits. However, those guidelines lack practical recommendations on ways to manage triage and diagnosis expressly for new cancer patients. Furthermore, there are no reports on the efficiency of the guidelines.    One of the main issues in treating musculoskeletal tumours is the complexity and variability of presentation. We offer a triage model, used in a quaternary-referral musculoskeletal oncology centre, that allows us to maintain an open pathway for referral of new patients while minimizing exposure risks. A multidisciplinary approach and analysis of existing investigations allow for a pre-clinic evaluation.    The model identifies 3 groups of patients: Patients with suspected high-grade malignancy, or benign cases with aggressive features, both in need of further evaluation in the clinic and prompt treatment Patients with low-grade malignancy, and benign cases whose treatment is not urgent, that are managed, during the pandemic by telemedicine, with reassurance and information about their illness Patients who can be managed by their local medical professionals    In comparison to a pre-pandemic period, that approach resulted in a higher ratio of malignant-to-benign con­ditions for new patients seen in the clinic (3:4 vs. 1:3 respectively), thus using available resources more efficiently and prioritizing patients with suspected high-grade malignancy.    We believe that this triage system could be applied in other surgical oncology fields during a pandemic.


2008 ◽  
Vol 179 (4S) ◽  
pp. 105-105
Author(s):  
Takefumi Satoh ◽  
Takeshi Sakata ◽  
Isao Okayasu ◽  
Golam Ferdous ◽  
Tomoko Tsuruta ◽  
...  

2015 ◽  
Vol 23 (5) ◽  
pp. 613-619 ◽  
Author(s):  
Kentaro Naito ◽  
Toru Yamagata ◽  
Hironori Arima ◽  
Junya Abe ◽  
Naohiro Tsuyuguchi ◽  
...  

OBJECT Although the usefulness of PET for brain lesions has been established, few reports have examined the use of PET for spinal intramedullary lesions. This study investigated the diagnostic utility of PET/CT for spinal intramedullary lesions. METHODS l-[methyl-11C]-methionine (MET)- or [18F]-fluorodeoxyglucose (FDG)-PET/CT was performed in 26 patients with spinal intramedullary lesions. The region of interest (ROI) within the spinal cord parenchyma was placed manually in the axial plane. Maximum pixel counts in the ROIs were normalized to the maximum standardized uptake value (SUVmax) using subject body weight. For FDG-PET the SUVmax was corrected for lean body mass (SULmax) to exclude any influence of the patient’s body shape. Each SUV was analyzed based on histopathological results after surgery. The diagnostic validity of the SUV was further compared with the tumor proliferation index using the MIB-1 monoclonal antibody (MIB-1 index). RESULTS A total of 16 patients underwent both FDG-PET and MET-PET, and the remaining 10 patients underwent either FDG-PET or MET-PET. Pathological diagnoses included high-grade malignancy such as glioblastoma multiforme, anaplastic astrocytoma, or anaplastic ependymoma in 5 patients; low-grade malignancy such as hemangioblastoma, diffuse astrocytoma, or ependymoma in 12 patients; and nonneoplastic lesion including cavernous malformation in 9 patients. Both FDG and MET accumulated significantly in high-grade malignancy, and the SULmax and SUVmax correlated with the tumor proliferation index. Therapeutic response after chemotherapy or radiation in high-grade malignancy was well monitored. However, a significant difference in SULmax and SUVmax for FDG-PET and MET-PET was not evident between low-grade malignancy and nonneoplastic lesions. CONCLUSIONS Spinal PET/CT using FDG or MET for spinal intramedullary lesions appears useful and practical, particularly for tumors with high-grade malignancy. Differentiation of tumors with low-grade malignancy from nonneoplastic lesions may still prove difficult. Further technological refinement, including the selection of radiotracer or analysis evaluation methods, is needed.


1993 ◽  
Vol 10 (4) ◽  
pp. 323-323
Author(s):  
P. Meldgaard ◽  
E. H. Holmes ◽  
E. P. Bennett ◽  
H. Clausen ◽  
J. Zeuthen ◽  
...  

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