Isolation and Characterization of Two New Compounds from Genus Sonchus

Two new compounds [1-2] were purified from ethyl acetate fraction of Quercus incana. The structure of these compounds is mainly established by using advanced spectroscopic technique such as UV, IR, one-dimensional (ID) and two-dimensional (2D) NMR techniques, and EI mass. The structural formula was deduced to be 4-hydroxydecanoic acid [1] and 4-hydroxy-3-(hydroxymethyl) pentanoic acid [2]. Both isolated compounds were tested for their antimicrobial potential and showed promising antifungal activity against Aspergillus niger and Aspergillus flavus.

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Isolation and Characterization of New Anti-Inflammatory and Antioxidant Components from Deep Marine-Derived Fungus Myrothecium sp. Bzo-l062

Marine Drugs ◽

10.3390/md18120597 ◽

2020 ◽

Vol 18 (12) ◽

pp. 597

Author(s):

Xiaojie Lu ◽

Junjie He ◽

Yanhua Wu ◽

Na Du ◽

Xiaofan Li ◽

...

Keyword(s):

Deep Sea ◽

High Performance ◽

Oxygen Radical ◽

Normal Phase ◽

Oxide Formation ◽

Nitric Oxide Formation ◽

Isolation And Characterization ◽

Anti Inflammatory ◽

New Compounds

In the present study, four new compounds including a pair of 2-benzoyl tetrahydrofuran enantiomers, namely, (−)-1S-myrothecol (1a) and (+)-1R-myrothecol (1b), a methoxy-myrothecol racemate (2), and an azaphilone derivative, myrothin (3), were isolated along with four known compounds (4–7) from cultures of the deep-sea fungus Myrothecium sp. BZO-L062. Enantiomeric compounds 1a and 1b were separated through normal-phase chiral high-performance liquid chromatography. The absolute configurations of 1a, 1b, and 3 were assigned by ECD spectra. Among them, the new compound 1a and its enantiomer 1b exhibited anti-inflammatory activity, inhibited nitric oxide formation in lipopolysaccharide-treated RAW264.7 cells, and exhibited antioxidant activity in the 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and oxygen radical absorbance capacity assays.

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Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.17.156 ◽

2021 ◽

Vol 17 ◽

pp. 2390-2398

Author(s):

Emmanuel Tope Oluwabusola ◽

Olusoji O Adebisi ◽

Fernando Reyes ◽

Kojo S Acquah ◽

Mercedes De La Cruz ◽

...

Keyword(s):

High Resolution Mass Spectrometry ◽

Antimicrobial Properties ◽

2D Nmr ◽

Culture Broth ◽

Moderate Activity ◽

North Central ◽

Isolation And Characterization ◽

Antimicrobial Evaluation ◽

New Compounds

Five new phenolic siderophores 1–5 were isolated from the organic extract of a culture broth in a modified SGG medium of Pseudomonas sp. UIAU-6B, obtained from sediments collected from the Oyun river in North Central Nigeria. The structure of the new compounds, pseudomonin A–C (1–3) and pseudomobactin A and B (4 and 5) isolated alongside two known compounds, pseudomonine (6) and salicylic acid (7), were elucidated based on high-resolution mass spectrometry, 1D and 2D NMR analyses. The absolute configuration of the threonine residue in compounds 1–5 was determined by Marfey analysis. The antimicrobial evaluation of compound 4 exhibited the most potent activity against vancomycin-sensitive Enterococcus faecium VS144754, followed by 3 and 5, with MIC values ranging from 8 to 32 µg/mL. Compounds 2 and 3 exhibited moderate activity against Mycobacterium tuberculosis H37Rv, with MIC values of 7.8 and 15.6 µg/mL, respectively. Plausible biosynthetic hypotheses toward the new compounds 1–5 were proposed.

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Isolation and Characterization of New Ceramides from Aerial Parts of Lepidaploa cotoneaster

Natural Product Communications ◽

10.1177/1934578x1200700623 ◽

2012 ◽

Vol 7 (6) ◽

pp. 1934578X1200700 ◽

Cited By ~ 1

Author(s):

Edlene O. dos Santos ◽

Marilena Meira ◽

Ademir E. do Vale ◽

Jorge M. David ◽

Luciano P. de Queiróz ◽

...

Keyword(s):

Fatty Acid ◽

Double Bond ◽

Dimethyl Disulfide ◽

Spectral Techniques ◽

H Nmr ◽

Aerial Parts ◽

Isolation And Characterization ◽

New Compounds ◽

C Nmr

Two new ceramides were isolated from the bulbs of Lepidaploa cotoneaster (Willd. ex Spreng.) H. Rob. [ Vernonia cotoneaster (Willd. ex Spreng.) Less.)], in addition to germanicol, β-sitosterol, stigmasterol, 3-β- O-β-D-glucopyranosyl-sitosterol, lupeol, lupeoyl acetate and tiliroside. The structures of the new compounds were elucidated by spectral techniques (MS, 1H NMR, 13C NMR, HSQC, HMBC, DEPT, and TOCSY) and were compared with data reported in literature, and were established as 2 S*,2′ R*,3 S*,4 R*,11 E)- N-[2′-hydroxyhenicosanoyl]-2-amino-nonadec-11-ene-1,3,4-triol (1) and (2 S*,2′ R*,3 S*,4 R*,8 E)- N-[2′-hydroxytricosanoyl]-2-amino-nonadec-8-ene-1,3,4-triol (2). To establish the structure and to locate the double bond, the methyl ester of the fatty acid and dimethyl disulfide (DMDS) derivatives were prepared for both ceramides.

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Isolation of the Tetrapeptide Apicidins G, H and I from the Fungus Fusarium semitectum

Natural Product Communications ◽

10.1177/1934578x1400900226 ◽

2014 ◽

Vol 9 (2) ◽

pp. 1934578X1400900

Author(s):

Suciati ◽

Mary J. Garson

Keyword(s):

2D Nmr ◽

Isolation And Characterization ◽

Fusarium Semitectum ◽

New Compounds

This study reports the isolation and characterization of three new tetrapeptides, apicidins G (1), H (2) and I (3), along with the known apicidin (4), apicidin A (5), apicidin C (6), diketopiperazine 7, equisetin (8) and 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (9). The structures of the new compounds were deduced by 2D NMR spectroscopic and MS data.

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