scholarly journals Current status of bone cementing and bone grafting for giant cell tumour of bone: a systemic review

2019 ◽  
Vol 101 (2) ◽  
pp. 79-85 ◽  
Author(s):  
R Vaishya ◽  
A Pokhrel ◽  
AK Agarwal ◽  
V Vijay
Keyword(s):  
Bone Graft ◽  
Bone Cement ◽  
Giant Cell ◽  
Recurrence Rate ◽  
Bone Grafting ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Systemic Review ◽  
Current Status ◽  
Intralesional Curettage

Introduction Extended intralesional curettage, together with bone grafting/cementing, is considered as a surgical treatment option for giant cell tumour of the bone. This study aimed to discover the efficacy and recurrence rate with the use of bone cement in giant cell tumour and to compare it with that of bone grafting. Material and methods The present systemic review is derived from the publications in the past 10 years (2009–2018). A literature search was performed via PubMed, using suitable keywords and Boolean operators database (‘Giant cell tumor,’ ‘osteoclastoma,’ ‘bone,’ ‘bone cement,’ ‘bone graft’ and ‘curettage’). A detailed statistical analysis of the data derived from the published literature was done. Results The patients who underwent bone graft only exhibited significantly higher recurrence rates than those treated with polymethyl methacrylate only (risk ratio 1.90; 95% confidence interval 1.14, 3.16; overall effect Z = 2.488; P-value 0.012). The observational analysis was done in rest of the seven studies; three studies showed no recurrence rate. Only one study reported the highest recurrence rate of 42% and the remaining six had an overall recurrence rate of 20.4%. Conclusion The use of bone cement was associated with a statistically significantly lower recurrence rate than bone grafting in giant cell tumour of bones. We therefore recommend the use of bone cement with extensive intralesional curettage. Adjuvant therapy like electrocautery, phenol irrigation and the use of intravenous denosumab or bisphosphonates may help in decreasing the incidence of recurrence in giant cell tumour of bone.

scholarly journals Management of Giant Cell Tumour by Curettage and Bone Cement in Weight Bearing Bone - A Study Done in DMCH & NITOR.

2017 ◽  
Vol 12 (1) ◽  
pp. 9-13
Author(s):  
Narayan Chandra Karmakar ◽  
Md Maiyeen Uddin ◽  
Md Masudur Rahman ◽  
Anadi Ranjan Mondal ◽  
Syed Asif Ul Alam
Keyword(s):  
Bone Cement ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Weight Bearing ◽  
Cell Tumour ◽  
Normal Appearance ◽  
Intralesional Curettage ◽  
Left Femur ◽  
Female Ratio ◽  
Excellent Outcome

Giant cell tumour of bone (GCT) has been characterized as benign but often locally aggressive neoplasm that commonly occurs in proximity to weight bearing bone. Management of giant cell tumor of bone by curettage and bone cement in weight bearing bone is an effective method. This prospective experimental study was conducted among the patients with histologically proved giant-cell tumour who were admitted in the Department of orthopedic surgery, Dhaka Medical College Hospital (DMCH) and in National Institute of Traumatology and Orthopaedic Rehabilitation (NITOR) over a period of 18 months from January 2010 to June 2011. A total of 18 consecutive patients with histologically proved giant-cell tumour were included in the study. Majority (55.6%) of patient was in 3rd decade and male female ratio was 1:1.3. More than one fourth (27.8%) of the patients had GCT in the lower end of right femur, 33.3% in lower end of left femur, 22.2% in upper end of right tibia, 16.7% in upper end of left tibia and all patients had painful gait and swelling. According to campanacci grading, Grade-2 was found in all patients, and giant cell tumour was found in all patients, as evaluated by pre-operative biopsy. Cosmetically near normal appearance was found in 88.9% and 88.9% were able to do normal daily work. According to Schatzker and Lambert (1979) criteria excellent outcome was found in 38.9%, good in 44.4%, fair in 11.1% and poor in 5.6%. Surgery in the form of intralesional curettage and filling the cavity with bone cement resulted in excellent relief of pain, cosmetically near normal appearance and patients were able to do normal daily work.Faridpur Med. Coll. J. Jan 2017;12(1): 9-13

Extended intralesional curettage preferred over resection–arthrodesis for giant cell tumour of the distal radius

2019 ◽  
Vol 30 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Hasan Abuhejleh ◽  
Jay S. Wunder ◽  
Peter C. Ferguson ◽  
Marc H. Isler ◽  
Sophie Mottard ◽  
...  
Keyword(s):  
Giant Cell ◽  
Distal Radius ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Intralesional Curettage

Trans-Foveal Approach for Curettage and Bone Grafting of a Giant Cell Tumour in the Femoral Head

2016 ◽  
Vol 26 (6) ◽  
pp. 612-614
Author(s):  
Hannes A. Rüdiger ◽  
Krzystof Piasecki ◽  
Fabio Becce ◽  
Stéphane Cherix
Keyword(s):  
Femoral Head ◽  
Giant Cell ◽  
Bone Grafting ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Case Presentation ◽  
Surgical Access ◽  
Surgical Dislocation ◽  
Articular Cartilage Lesions

Background Surgical access to benign neoplastic lesions of the femoral head are associated with significant morbidity, including contamination of intra-osseous access tracks, articular cartilage lesions, avascular bone necrosis or tumour recurrence due to incomplete curettage. Case presentation We present a case of a 20-year-old female with a giant cell tumour in the femoral head, which was treated with curettage through a trans-foveal approach and bone grafting. This technique includes a surgical dislocation of the hip with trochanteric osteotomy. Results At the latest follow-up at 2 years, there was no evidence of local recurrence or avascular necrosis on MRI, and the patient was pain free and back to sports.

scholarly journals ANALYSIS OF GIANT CELL TUMOUR OF BONES: ITS PATTERN, VARIOUS TREATMENT MODALITIES AND THEIR RESULTS

2018 ◽  
Author(s):  
Anil Pandey ◽  
Pratyush Goyal ◽  
Deepak S , Maravi ◽  
S Uikey
Keyword(s):  
Knee Joint ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Lung Metastases ◽  
Histopathological Examination ◽  
Cell Tumour ◽  
Treatment Modalities ◽  
Tumour Mass ◽  
Intralesional Curettage ◽  
Extended Curettage

Background: Giant cell tumour is a benign aggressive tumour of bone accounting for 5% of all primary bone tumours with feature of local recurrence, potential for metastasis and malignant transformation and usually seen at the end of long bones after skeletal maturity. The incidence of lung metastases from a histologically-proven GCT ranges from 1% to 9%. The recurrence rate after intralesional curettage without adjuvant therapy is reported to be up to 50%. Extended curettage with use of adjuvents is the treatment of choice for treating the most GCT of bones. Material and method: 25 patients presented with GCTBs included.In all patients standard plain anteroposterior and lateral radiographs of the involved extremity were done.MRI of involved extremity was done in 19 cases. Diagnosis confirmed by biopsy and histopathological examination. The treatment of GCT is directed towards local control without scarifying joint function. This has been traditionally achieved by intralesional curettage with autograft reconstruction by packing the cavity of excised tumour with iliac cortico-cancellous bone.  Results: We have treated 25 patients of GCTBs. Females (15) were more commonly affected than male (10). Most common site for GCT was around the knee joint mostly in proximal tibia (6 out of 25). Average range of motion of knee joint was 60 to 112 degree and in wrist joint it was 0 to 45 degree of palmar flexion and 0 to 30 degree of dorsi flexion. Conclusion: We believe that removal of most of tumour mass by extended curettage is very essential step in preventing recurrence and achieving good functional outcome in future. Key words: giant cell tumour of bones, autograft, extended curettage

scholarly journals Computerised tomography features of giant cell tumour of the knee are associated with local recurrence after extended curettage

2021 ◽  
Author(s):  
Lenian Zhou ◽  
Hongyi Zhu ◽  
Shanyi Lin ◽  
Hanqiang Jin ◽  
Zhaoyuan Zhang ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Local Recurrence ◽  
Giant Cell ◽  
Recurrence Rate ◽  
Prognostic Value ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
High Recurrence Rate ◽  
Multivariate Logistic Regression ◽  
Extended Curettage

Abstract Background Extended curettage has increasingly become the preferred treatment for giant cell tumour of bone (GCTB), but the high recurrence rate after curettage poses a major challenge for orthopaedic surgeons. Computed tomography (CT) is valuable in the evaluation of GCTB. Our aim was to identify specific features of GCTB around the knee in pre-operative CT images that might have prognostic value for local recurrence. Methods We retrospectively analyzed data from 124 patients with primary GCTB around the knee who underwent extended curettage from 2010 through 2019. We collected demographic, clinical, and therapeutic data along with several CT-derived tumour characteristics. CT-derived tumor characteristics included tumour size, the distance between the tumour edge and articular surface (DTA), and destruction of posterior cortical bone (DPC). Akaike information criterion (AIC) was used to select which variables to enter into multivariate logistic regression models and to determine significant factors affecting recurrence. Results The total recurrence rate was 21.0% (26/124), and the average follow-up time was 69.5 ± 31.2 months (24–127 months). Age, DTA (< 2 mm), and DPC were significantly related to recurrence, as determined by multivariate logistic regression. The C-index of the final model was 0.79 (95% CI: 0.71 to 0.88), representing a good model for predicting recurrence. Conclusion Identifying certain features of GCTB around the knee on CT has prognostic value for patients treated with extended curettage. A three-factor model predicts tumour recurrence well after extended curettage.

scholarly journals Pretibial Full Thickness Skin Burn following Indirect Contact from Bone-Cement Use in a Giant Cell Tumour

Sarcoma ◽  
2007 ◽  
Vol 2007 ◽  
pp. 1-4 ◽  
Author(s):  
Buchi Rajendra Babu Arumilli ◽  
Ashok Samuel Paul
Keyword(s):  
Bone Cement ◽  
Giant Cell ◽  
Direct Contact ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Full Thickness ◽  
Skin Damage ◽  
Skin Burn ◽  
Indirect Contact ◽  
Thickness Skin

Bone cement reaches significant temperatures and is known to cause thermal and chemical damage to various tissues. All the reports of such damage occurred following a direct contact of the tissue or structure with cement. We report the case of a patient with a giant cell tumour of the proximal tibia who underwent curettage and bone cement application through a posterior approach and subsequently developed full thickness pretibial skin damage despite showing no evidence of any direct contact of the involved skin with bone cement. This is the first report of its kind and though anecdotal is a serious complication that surgeons should be aware of.

scholarly journals Giant cell tumour of the patella with local recurrence: successful management with excision, curettage and artificial bone grafting

2018 ◽  
pp. bcr-2017-221275
Author(s):  
Timothy Mark Morris ◽  
Zakareya Gamie ◽  
Kanishka Milton Ghosh ◽  
Kenneth Samora Rankin
Keyword(s):  
Local Recurrence ◽  
Giant Cell ◽  
Bone Grafting ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Artificial Bone ◽  
Successful Management

scholarly journals Synchronous Multicentric Giant Cell Tumour of Distal Radius and Sacrum with Pulmonary Metastases

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Varun Sharma Tandra ◽  
Krishna Mohan Reddy Kotha ◽  
Moorthy Gadisetti Venkata Satyanarayana ◽  
Kali Varaprasad Vadlamani ◽  
Vyjayanthi Yerravalli
Keyword(s):  
Giant Cell ◽  
Distal Radius ◽  
Bone Grafting ◽  
Giant Cell Tumour ◽  
Pulmonary Metastases ◽  
Osteolytic Lesion ◽  
Bone Tumour ◽  
Cell Tumour ◽  
Primary Bone Tumour ◽  
Primary Bone

Giant cell tumour (GCT) is an uncommon primary bone tumour, and its multicentric presentation is exceedingly rare. We report a case of a 45-year-old female who presented to us with GCT of left distal radius. On the skeletal survey, osteolytic lesion was noted in her right sacral ala. Biopsy confirmed both lesions as GCT. Pulmonary metastasis was also present. Resection-reconstruction arthroplasty for distal radius and thorough curettage and bone grafting of the sacral lesion were done. Multicentric GCT involving distal radius and sacrum with primary sacral involvement is not reported so far to our knowledge.

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