scholarly journals Giant cell tumour of the patella with local recurrence: successful management with excision, curettage and artificial bone grafting

2018 ◽  
pp. bcr-2017-221275
Author(s):  
Timothy Mark Morris ◽  
Zakareya Gamie ◽  
Kanishka Milton Ghosh ◽  
Kenneth Samora Rankin
Keyword(s):  
Local Recurrence ◽  
Giant Cell ◽  
Bone Grafting ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Artificial Bone ◽  
Successful Management

Trans-Foveal Approach for Curettage and Bone Grafting of a Giant Cell Tumour in the Femoral Head

2016 ◽  
Vol 26 (6) ◽  
pp. 612-614
Author(s):  
Hannes A. Rüdiger ◽  
Krzystof Piasecki ◽  
Fabio Becce ◽  
Stéphane Cherix
Keyword(s):  
Femoral Head ◽  
Giant Cell ◽  
Bone Grafting ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Case Presentation ◽  
Surgical Access ◽  
Surgical Dislocation ◽  
Articular Cartilage Lesions

Background Surgical access to benign neoplastic lesions of the femoral head are associated with significant morbidity, including contamination of intra-osseous access tracks, articular cartilage lesions, avascular bone necrosis or tumour recurrence due to incomplete curettage. Case presentation We present a case of a 20-year-old female with a giant cell tumour in the femoral head, which was treated with curettage through a trans-foveal approach and bone grafting. This technique includes a surgical dislocation of the hip with trochanteric osteotomy. Results At the latest follow-up at 2 years, there was no evidence of local recurrence or avascular necrosis on MRI, and the patient was pain free and back to sports.

scholarly journals Computerised tomography features of giant cell tumour of the knee are associated with local recurrence after extended curettage

2021 ◽  
Author(s):  
Lenian Zhou ◽  
Hongyi Zhu ◽  
Shanyi Lin ◽  
Hanqiang Jin ◽  
Zhaoyuan Zhang ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Local Recurrence ◽  
Giant Cell ◽  
Recurrence Rate ◽  
Prognostic Value ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
High Recurrence Rate ◽  
Multivariate Logistic Regression ◽  
Extended Curettage

Abstract Background Extended curettage has increasingly become the preferred treatment for giant cell tumour of bone (GCTB), but the high recurrence rate after curettage poses a major challenge for orthopaedic surgeons. Computed tomography (CT) is valuable in the evaluation of GCTB. Our aim was to identify specific features of GCTB around the knee in pre-operative CT images that might have prognostic value for local recurrence. Methods We retrospectively analyzed data from 124 patients with primary GCTB around the knee who underwent extended curettage from 2010 through 2019. We collected demographic, clinical, and therapeutic data along with several CT-derived tumour characteristics. CT-derived tumor characteristics included tumour size, the distance between the tumour edge and articular surface (DTA), and destruction of posterior cortical bone (DPC). Akaike information criterion (AIC) was used to select which variables to enter into multivariate logistic regression models and to determine significant factors affecting recurrence. Results The total recurrence rate was 21.0% (26/124), and the average follow-up time was 69.5 ± 31.2 months (24–127 months). Age, DTA (< 2 mm), and DPC were significantly related to recurrence, as determined by multivariate logistic regression. The C-index of the final model was 0.79 (95% CI: 0.71 to 0.88), representing a good model for predicting recurrence. Conclusion Identifying certain features of GCTB around the knee on CT has prognostic value for patients treated with extended curettage. A three-factor model predicts tumour recurrence well after extended curettage.

scholarly journals Synchronous Multicentric Giant Cell Tumour of Distal Radius and Sacrum with Pulmonary Metastases

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Varun Sharma Tandra ◽  
Krishna Mohan Reddy Kotha ◽  
Moorthy Gadisetti Venkata Satyanarayana ◽  
Kali Varaprasad Vadlamani ◽  
Vyjayanthi Yerravalli
Keyword(s):  
Giant Cell ◽  
Distal Radius ◽  
Bone Grafting ◽  
Giant Cell Tumour ◽  
Pulmonary Metastases ◽  
Osteolytic Lesion ◽  
Bone Tumour ◽  
Cell Tumour ◽  
Primary Bone Tumour ◽  
Primary Bone

Giant cell tumour (GCT) is an uncommon primary bone tumour, and its multicentric presentation is exceedingly rare. We report a case of a 45-year-old female who presented to us with GCT of left distal radius. On the skeletal survey, osteolytic lesion was noted in her right sacral ala. Biopsy confirmed both lesions as GCT. Pulmonary metastasis was also present. Resection-reconstruction arthroplasty for distal radius and thorough curettage and bone grafting of the sacral lesion were done. Multicentric GCT involving distal radius and sacrum with primary sacral involvement is not reported so far to our knowledge.

In-depth analysis of local recurrence of giant cell tumour of bone with soft tissue extension after intralesional curettage

2014 ◽  
Vol 119 (11) ◽  
pp. 861-870 ◽  
Author(s):  
Liang Chen ◽  
Xiao-Yi Ding ◽  
Chengs-Sheng Wang ◽  
Ming-Jue Si ◽  
Lian-Jun Du ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Local Recurrence ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Intralesional Curettage ◽  
Soft Tissue Extension ◽  
Depth Analysis

Prognosis of local recurrence in giant cell tumour of bone: what can we do?

2017 ◽  
Vol 122 (7) ◽  
pp. 505-519 ◽  
Author(s):  
Yifeng He ◽  
Ji Zhang ◽  
Xiaoyi Ding
Keyword(s):  
Local Recurrence ◽  
Giant Cell ◽  
Giant Cell Tumour ◽  
Cell Tumour

scholarly journals Current status of bone cementing and bone grafting for giant cell tumour of bone: a systemic review

2019 ◽  
Vol 101 (2) ◽  
pp. 79-85 ◽  
Author(s):  
R Vaishya ◽  
A Pokhrel ◽  
AK Agarwal ◽  
V Vijay
Keyword(s):  
Bone Graft ◽  
Bone Cement ◽  
Giant Cell ◽  
Recurrence Rate ◽  
Bone Grafting ◽  
Giant Cell Tumour ◽  
Cell Tumour ◽  
Systemic Review ◽  
Current Status ◽  
Intralesional Curettage

Introduction Extended intralesional curettage, together with bone grafting/cementing, is considered as a surgical treatment option for giant cell tumour of the bone. This study aimed to discover the efficacy and recurrence rate with the use of bone cement in giant cell tumour and to compare it with that of bone grafting. Material and methods The present systemic review is derived from the publications in the past 10 years (2009–2018). A literature search was performed via PubMed, using suitable keywords and Boolean operators database (‘Giant cell tumor,’ ‘osteoclastoma,’ ‘bone,’ ‘bone cement,’ ‘bone graft’ and ‘curettage’). A detailed statistical analysis of the data derived from the published literature was done. Results The patients who underwent bone graft only exhibited significantly higher recurrence rates than those treated with polymethyl methacrylate only (risk ratio 1.90; 95% confidence interval 1.14, 3.16; overall effect Z = 2.488; P-value 0.012). The observational analysis was done in rest of the seven studies; three studies showed no recurrence rate. Only one study reported the highest recurrence rate of 42% and the remaining six had an overall recurrence rate of 20.4%. Conclusion The use of bone cement was associated with a statistically significantly lower recurrence rate than bone grafting in giant cell tumour of bones. We therefore recommend the use of bone cement with extensive intralesional curettage. Adjuvant therapy like electrocautery, phenol irrigation and the use of intravenous denosumab or bisphosphonates may help in decreasing the incidence of recurrence in giant cell tumour of bone.

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