Enoxaparin-Induced Thrombocytopenia Resulting in Systemic Bleeding; Cyclosporine-Induced Infantile Nodulocystic Acne; Aloe-Induced Hypokalemia; Sertraline-Induced Rhabdomyolysis; Hallucinations Associated with Modafinil; Ziprasidone-Induced Angioedema; Colonic Necrosis with Sodium Polystyrene Sulfonate — Redux

2009 ◽  
Vol 44 (10) ◽  
pp. 854-857 ◽  
Author(s):  
Joel Shuster
Keyword(s):  
Adverse Drug Reactions ◽  
Sodium Polystyrene Sulfonate ◽  
Polystyrene Sulfonate ◽  
Drug Reactions ◽  
The Us ◽  
Colonic Necrosis

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers.

Cetirizine-Induced Anaphylaxis; Celecoxib-Associated Anaphylaxis; Levetiracetam-Induced Pancytopenia; Trismus Induced by Fluoxetine; Aliskiren-Induced QT Interval Prolongation; Intestinal Necrosis Resulting from Sodium Polystyrene Sulfonate

2009 ◽  
Vol 44 (8) ◽  
pp. 658-661 ◽  
Author(s):  
Joel Shuster
Keyword(s):  
Adverse Drug Reactions ◽  
Qt Interval ◽  
Sodium Polystyrene Sulfonate ◽  
Polystyrene Sulfonate ◽  
Drug Reactions ◽  
Interval Prolongation ◽  
Intestinal Necrosis ◽  
Qt Interval Prolongation ◽  
The Us

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers.

scholarly journals A Real-World, Multicenter Assessment of Drugs Requiring Weight-Based Calculations in Overweight, Adult Critically Ill Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Sandra L. Kane-Gill ◽  
Nicholas P. Wytiaz ◽  
Lisa M. Thompson ◽  
Karina Muzykovsky ◽  
Mitchell S. Buckley ◽  
...  
Keyword(s):  
High Risk ◽  
Adverse Drug Reactions ◽  
Real World ◽  
Drug Reactions ◽  
Multicenter Observational Study ◽  
Increased Risk ◽  
The Us ◽  
Overweight Adult ◽  
Body Mass Indexes ◽  
Prospective Multicenter Observational Study

Prescribing appropriate doses of drugs requiring weight-based dosing is challenging in overweight patients due to a lack of data. With 68% of the US population considered overweight and these patients being at an increased risk for hospitalization, clinicians need guidance on dosing weight-based drugs. The purpose of this study was to identify “real-world” dose ranges of high-risk medications administered via continuous infusion requiring weight-based dosing and determine the reasons for dosing changes (ineffectiveness or adverse drug reactions). A prospective, multicenter, observational study was conducted in four intensive care units at three institutions. A total of 857 medication orders representing 11 different high-risk medications in 173 patients were reviewed. It was noted that dosing did not increase in proportion to weight classification. Overall, 14 adverse drug reactions occurred in nine patients with more in overweight patients (9 of 14). A total of 75% of orders were discontinued due to ineffectiveness in groups with higher body mass indexes. Ineffectiveness leads to dosing adjustments resulting in the opportunity for medication errors. Also, the frequent dosing changes further demonstrate our lack of knowledge of appropriate dosing for this population. Given the medications’ increased propensity to cause harm, institutions should aggressively monitor these medications in overweight patients.

Trimethoprim/Sulfamethoxazole-Induced Higher-Level Gait Disorder Aggrenox-Induced Stevens-Johnson Syndrome Serum Sickness–Like Reaction to Efalizumab Fluoroquinolone-Associated Achilles Tendinitis Severe Hyperglycemic, Hyperosmolar, Nonketotic Coma in a Patient Without Diabetes Receiving Aripiprazole Antidepressant-Induced Nightmares

2009 ◽  
Vol 44 (5) ◽  
pp. 379-382
Author(s):  
Joel Shuster
Keyword(s):  
Adverse Drug Reactions ◽  
Serum Sickness ◽  
Stevens Johnson Syndrome ◽  
Gait Disorder ◽  
Drug Reactions ◽  
Achilles Tendinitis ◽  
Johnson Syndrome ◽  
The Us ◽  
Hyperglycemic Hyperosmolar Nonketotic Coma

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers.

scholarly journals Deferasirox-Induced Serious Metabolic Abnormalities; Bicalutamide-Induced Heart Failure; Combination Ipilimumab and Nivolumab–Induced Lethal Myocarditis; Polymyxin B-Trimethoprim Eye Drop–Induced Anaphylaxis; Methylphenidate-Induced Diffuse Maculopapular Rash

2017 ◽  
Vol 52 (3) ◽  
pp. 172-176
Author(s):  
Michael A. Mancano
Keyword(s):  
Heart Failure ◽  
Adverse Drug Reactions ◽  
Maculopapular Rash ◽  
Polymyxin B ◽  
Metabolic Abnormalities ◽  
Drug Reactions ◽  
The Us

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers.

scholarly journals Kayexalate-Induced Esophageal Ulceration in a Patient with Decompensated Cirrhosis: A Review of the Literature

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Kishore Kumar ◽  
Harish Patel ◽  
Muhammad Saad ◽  
Ahmed Baiomi ◽  
Anil Dev
Keyword(s):  
Clinical Medicine ◽  
The Body ◽  
Decompensated Cirrhosis ◽  
Sodium Polystyrene Sulfonate ◽  
Esophageal Ulcer ◽  
Polystyrene Sulfonate ◽  
Colonic Necrosis ◽  
Cation Exchange Resins ◽  
Gastrointestinal Side Effects ◽  
Exchange Resins

Hyperkalemia is one of the most common electrolyte abnormalities encountered in clinical practice. The treatment of hyperkalemia includes removal of excess potassium from the body using cation exchange resins, e.g., sodium polystyrene sulfonate (Kayexalate) is one of the most practiced modalities in clinical medicine. Colonic mucosal necrosis and perforation are the serious gastrointestinal side effects associated with sodium polystyrene sulfonate (SPS) use, which have been reported with or without concomitant use of sorbitol. However, the catastrophic bleeding esophageal ulcer has been rarely described in our literature search. Due to the risk of colonic necrosis, the FDA has issued a warning to avoid concomitant sorbitol use with Kayexalate. We present an individual with acute hematemesis due to bleeding esophageal ulcer immediately after treatment with Kayexalate therapy. Though the exact mechanism by which Kayexalate causes esophageal ulcer to be elucidated, nonetheless it is worthwhile to be vigilant about its potential adverse effects. Our case highlights the rare but certainly the life-threatening complication of Kayexalate therapy.

scholarly journals ISMP Adverse Drug Reactions: Pheochromocytoma Crisis Induced by Metoclopramide Baclofen Dependence Following High-Dose Therapy Fatal Cardiotoxicity Following High-Dose Cyclophosphamide Acute Anterograde Amnestic Syndrome Induced by Fentanyl Ivermectin-Induced Toxic Epidermal Necrolysis Pembrolizumab-Induced Type 1 Diabetes

2019 ◽  
Vol 54 (4) ◽  
pp. 241-245
Author(s):  
Michael A. Mancano ◽  
Jonathan Lapin ◽  
Andrew Paik
Keyword(s):  
Adverse Drug Reactions ◽  
High Dose ◽  
Drug Reactions ◽  
High Dose Therapy ◽  
Safe Medication ◽  
Temple University ◽  
The Us ◽  
Amnestic Syndrome ◽  
E Mail

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration’s (FDA) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers. E-mail Dr. Mancano at [email protected] . Your report will be published anonymously unless otherwise requested. This feature is provided by the Institute for Safe Medication Practices (ISMP) in cooperation with the FDA’s MedWatch program and Temple University School of Pharmacy. ISMP is an FDA MedWatch partner.

Incidence of Sodium Polystyrene Sulfonate-associated Colonic Necrosis

2013 ◽  
Vol 126 (9) ◽  
pp. e13 ◽  
Author(s):  
Christina M. Yuan ◽  
Robert Nee ◽  
Dustin J. Little ◽  
Kevin C. Abbott
Keyword(s):  
Sodium Polystyrene Sulfonate ◽  
Polystyrene Sulfonate ◽  
Colonic Necrosis

Rash Associated with Dabigatran; Skin Necrosis Induced by Generic Enoxaparin; Serotonin Syndrome with Concomitant Use of Tapentadol and Venlafaxine; Etanercept-Induced Henoch-Schönlein Purpura; Vemurafenib-Associated Pancreatitis

2013 ◽  
Vol 48 (7) ◽  
pp. 542-549 ◽  
Author(s):  
Michael A. Mancano
Keyword(s):  
Adverse Drug Reactions ◽  
Skin Necrosis ◽  
Serotonin Syndrome ◽  
Drug Reactions ◽  
Henoch Schonlein Purpura ◽  
The Us ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported an interesting, preventable ADR to MedWatch, please consider sharing the account with our readers.

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