In vivo multivariate calibration models developed using real and sham reference oxygen saturation data

2000 ◽  
Author(s):  
Ndumiso A. Cingo ◽  
Babs R. Soller
Keyword(s):  
Oxygen Saturation ◽  
Multivariate Calibration ◽  
Calibration Models

Strategy for constructing robust multivariate calibration models

1999 ◽  
Vol 49 (1) ◽  
pp. 1-17 ◽  
Author(s):  
H. Swierenga ◽  
A.P. de Weijer ◽  
R.J. van Wijk ◽  
L.M.C. Buydens
Keyword(s):  
Multivariate Calibration ◽  
Calibration Models

scholarly journals Optical Measurement of Blood Oxygen Saturation of Dental Pulp

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Satoko Kakino ◽  
Shinya Kushibiki ◽  
Azusa Yamada ◽  
Zenzo Miwa ◽  
Yuzo Takagi ◽  
...  
Keyword(s):  
Light Intensity ◽  
Oxygen Saturation ◽  
Dental Pulp ◽  
Optical Measurement ◽  
Blood Oxygen ◽  
Arterial Pulse ◽  
Blood Oxygen Saturation ◽  
Visible Wavelengths

The applicability of arterial pulse oximetry to dental pulp was demonstrated using in vitro and in vivo measurements. First, porcine blood of known oxygen saturation (SO2) was circulated through extracted human upper incisors, while transmitted-light plethysmography was performed using three different visible wavelengths. From the light intensity waveforms measured in vitro, a parameter that is statistically correlated to SO2 was calculated using the pulsatile/nonpulsatile component ratios of two wavelengths for different SO2. Then, values were measured in vivo for living incisors, and the corresponding SO2 values were calculated using the results of in vitro measurements. The estimated SO2 values of the upper central incisors measured in vivo were from 71.0 to 92.7%. This study showed the potential to measure the oxygen saturation changes to identify the sign of pulpal inflammation.

In Vivo Estimation of Oxygen Saturation of Hemoglobin in Hepatic Lobules in Rats

1988 ◽  
pp. 591-596 ◽  
Author(s):  
Hiroshi Eguchi ◽  
Nobuhiro Sato ◽  
Takakatsu Matsumura ◽  
Sunao Kawano ◽  
Takenobu Kamada
Keyword(s):  
Oxygen Saturation

Monitoring the Effect of PDT on in Vivo Oxygen Saturation and Microvascular Circulation

2003 ◽  
pp. 235-244 ◽  
Author(s):  
Josephine H. Woodhams ◽  
Lars Kunz ◽  
Stephen G. Bown ◽  
Alexander J. MacRobert
Keyword(s):  
Oxygen Saturation

Linear transformations of multivariate calibration models in near infrared spectroscopy: A comparative study

2017 ◽  
Vol 25 (4) ◽  
pp. 223-230 ◽  
Author(s):  
Joseph Dubrovkin
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Multivariate Calibration ◽  
Cetane Number ◽  
Total Protein Content ◽  
Prediction Errors ◽  
Calibration Data ◽  
Linear Transformations ◽  
Calibration Models

It was shown that linear transformations are suitable for use in multivariate calibration in near infrared spectroscopy as data compression tools. Partial Least Squares calibration models were built using spectral data transformed by expansion in the series of classical orthogonal polynomials, Fourier and wavelet harmonics. These models allowed effective prediction of the cetane number of diesel fuels, Brix and pol parameters of syrup in sugar production and fat and total protein content in milk. Depending on the compression ratio, prediction errors were no larger than 30% of corresponding errors obtained by the use of the non-transformed models. Although selection of the most suitable transformation depends on the calibration data and on the cross-validation method, in many cases Fourier transform gave satisfactory results.

Maintaining the predictive abilities of multivariate calibration models by spectral space transformation

2011 ◽  
Vol 690 (1) ◽  
pp. 64-70 ◽  
Author(s):  
Wen Du ◽  
Zeng-Ping Chen ◽  
Li-Jing Zhong ◽  
Shu-Xia Wang ◽  
Ru-Qin Yu ◽  
...  
Keyword(s):  
Multivariate Calibration ◽  
Spectral Space ◽  
Space Transformation ◽  
Calibration Models

scholarly journals Different spectrophotometric and TLC-densitometric methods for determination of olmesartan medoxomil and hydrochlorothiazide and their degradation products

2018 ◽  
Vol 9 (4) ◽  
pp. 400-407 ◽  
Author(s):  
Selvia Maged Adly ◽  
Maha Mohamed Abdelrahman ◽  
Nada Sayed Abdelwahab ◽  
Nourudin Wageh Ali
Keyword(s):  
Multivariate Calibration ◽  
Degradation Products ◽  
External Validation ◽  
Olmesartan Medoxomil ◽  
Partial Least Square ◽  
Least Square ◽  
Pharmaceutical Dosage Form ◽  
Calibration Models ◽  
Significant Difference

In this work, multivariate calibration models and TLC-densitometric methods have been developed and validated for quantitative determination of olmesartan medoxomil (OLM) and hydrochlorothiazide (HCZ) in presence of their degradation products, olmesartan (OL) and salamide (SAL), respectively. In the first method, multivariate calibration models including principal component regression (PCR) and partial least square (PLS) were applied. The wavelength range 210-343 nm was used and data was auto-scaled and mean centered as pre-processing steps for PCR and PLS models, respectively. These models were tested by application to external validation set with mean percentage recoveries 99.78, 100.01, 100.41 and 100.46% for OLM, HCZ, OL and SAL, respectively, for PLS model and also, 100.22, 100.40, 102.25 and 100.13% for them, respectively, for PCR model. The second method is TLC-densitometry at which the chromatographic separation was carried out using silica gel 60F254 TLC plates and the developing system consisted of a mixture of ethyl acetate:chloroform:methanol: formic acid:tri-ethylamine (60:40:4:4:1, by volume) with UV-scanning at 254 nm. The developed methods were successfully applied for determination of OLM and HCZ in their pharmaceutical dosage form. Also, statistical comparison was made between the developed methods and the reported method using student’s-t test and F-test and results showed that there was no significant difference between them concerning both accuracy and precision.

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