scholarly journals Waveguide Properties of Cone Photoreceptors

Author(s):  
Donald T. Miller
Keyword(s):  
PLoS Genetics ◽  
2013 ◽  
Vol 9 (6) ◽  
pp. e1003555 ◽  
Author(s):  
Kyoung-in Cho ◽  
MdEmdadul Haque ◽  
Jessica Wang ◽  
Minzhong Yu ◽  
Ying Hao ◽  
...  

1997 ◽  
Vol 14 (4) ◽  
pp. 609-615 ◽  
Author(s):  
Shu-Ichi Watanabe ◽  
Jing Shen

AbstractEffects of ATP on the activity of cGMP-gated channels from carp cone photoreceptors were studied. In 29% of the patches examined (N = 45), ATP (1 mM) enhanced a current evoked by cGMP (20 μM, up to about 100%), in 33%, ATP suppressed it by up to about 90%, and in the remaining 38%, ATP had no effect. ATP showed similar effects on a current evoked by 8-bromoguanosine 3′,5′-cyclic monophosphate (2 μM, enhancing in 42% of the patches, suppressing in 25%, no effect in 33%, N = 12), suggesting that the effects were not through modulation of the phosphodiesterase. Both of the effects, enhancement and suppression, were produced by a change in apparent affinity for cGMP, since (1) the maximum current evoked by cGMP of the saturating concentration (≥1 mM) was not affected, and (2) the A1/2 value decreased by approximately 45% (N = 2) or increased by approximately 25% (N = 2). A lower pH (approximately 6) facilitated the enhancing effect. ATP-γ-S (1 mM) showed a suppressing effect in 80% of the patches and no effect in 20% of the patches (N = 10). However, ATP-γ-S did not show an enhancing effect. Thus, ATP had two opposite effects through different mechanisms on the apparent sensitivity of the channel to cGMP; increasing and decreasing.


1999 ◽  
Vol 96 (9) ◽  
pp. 5251-5256 ◽  
Author(s):  
Y. Wang ◽  
P. M. Smallwood ◽  
M. Cowan ◽  
D. Blesh ◽  
A. Lawler ◽  
...  

2000 ◽  
Vol 163 (1) ◽  
pp. 207-219 ◽  
Author(s):  
Xiaoping Xu ◽  
Alexander B. Quiambao ◽  
Luisa Roveri ◽  
Machelle T. Pardue ◽  
Jeffrey L. Marx ◽  
...  
Keyword(s):  

2014 ◽  
Vol 55 (2) ◽  
pp. 881 ◽  
Author(s):  
Junzo Kinoshita ◽  
Noriaki Iwata ◽  
Tomofumi Kimotsuki ◽  
Mitsuya Yasuda
Keyword(s):  

1996 ◽  
Vol 36 (8) ◽  
pp. 1067-1079 ◽  
Author(s):  
Donald T. Miller ◽  
David R. Williams ◽  
G. Michael Morris ◽  
Junzhong Liang

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