scholarly journals Three-dimensional assessment of para- and perifoveal photoreceptor densities and the impact of meridians and age in healthy eyes with adaptive-optics optical coherence tomography (AO-OCT)

2020 ◽  
Vol 28 (24) ◽  
pp. 36723
Author(s):  
Adrian Reumueller ◽  
Lorenz Wassermann ◽  
Matthias Salas ◽  
Markus Schranz ◽  
Reinhard Told ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Adaptive Optics ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Dimensional Assessment ◽  
The Impact ◽  
Healthy Eyes

scholarly journals Three-dimensional composition of the photoreceptor cone layers in healthy eyes using adaptive-optics optical coherence tomography (AO-OCT)

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245293
Author(s):  
Adrian Reumueller ◽  
Lorenz Wassermann ◽  
Matthias Salas ◽  
Markus Schranz ◽  
Valentin Hacker ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Adaptive Optics ◽  
Outer Segment ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Cone Photoreceptors ◽  
Cone Mosaic ◽  
Automated Technique ◽  
Healthy Eyes ◽  
Cone Density

Purpose To assess the signal composition of cone photoreceptors three-dimensionally in healthy retinas using adaptive optics optical coherence tomography (AO-OCT). Methods Study population. Twenty healthy eyes of ten subjects (age 23 to 67). Procedures. After routine ophthalmological assessments, eyes were examined using AO-OCT. Three-dimensional volumes were acquired at 2.5° and 6.5° foveal eccentricity in four main meridians (superior, nasal, inferior, temporal). Cone densities and signal compositions were investigated in four different planes: the cone inner segment outer segment junction (IS/OS), the cone outer segment combined with the IS/OS (ISOS+), the cone outer segment tips (COST) and full en-face plane (FEF) combining signals from all mentioned cone layers. Additionally, reliability of a simple semi-automated approach for assessment of cone density was tested. Main outcome measures. Cone density of IS/OS, IS/OS+, COST and FEF. Qualitative depiction and composition of each cone layer. Inter-rater agreement of cone density measurements. Results Mean overall cone density at all eccentricities was highest at the FEF plane (21.160/mm2), followed by COST (20.450/mm2), IS/OS+ (19.920/mm2) and IS/OS (19.530/mm2). The different meridians and eccentricities had a significant impact on cone density, with lower eccentricity resulting in higher cone densities (p≤.001), which were highest at the nasal, then temporal, then inferior and then superior meridian. Depiction of the cone mosaic differed between all 4 layers regarding signal size and packing density. Therefore, different cone layers showed evident but not complete signal overlap. Using the semi-automated technique for counting of cone signals achieved high inter-rater reliability (ICC > .99). Conclusions In healthy individuals qualitative and quantitative changes in cone signals are found not only in different eccentricities and meridians, but also within different photoreceptor layers. The variation between cone planes has to be considered when assessing the integrity of cone photoreceptors in healthy and diseased eyes using adaptive optics technology.

scholarly journals Evaluating Retinal and Choroidal Perfusion Changes After Ocular Massage of Healthy Eyes Using Optical Coherence Tomography Angiography

Medicina ◽  
2020 ◽  
Vol 56 (12) ◽  
pp. 645
Author(s):  
Felix Rommel ◽  
Sabine Lüken ◽  
Michelle Prasuhn ◽  
Maximilian Kurz ◽  
Vinodh Kakkassery ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Treatment Option ◽  
Optical Coherence Tomography Angiography ◽  
Retinal Artery Occlusion ◽  
Artery Occlusion ◽  
Optical Coherence ◽  
Capillary Plexus ◽  
Retinal Artery ◽  
The Impact ◽  
Healthy Eyes

Background and objectives: Ocular massage (OM) is used as a treatment option for acute retinal artery occlusion, under the assumption that it induces vessel dilatation and enhances perfusion. Since evidence of ocular perfusion alteration due to OM is lacking, we investigate the impact of OM on the hemodynamics of the posterior pole in healthy eyes in a noninvasive fashion by using optical coherence tomography angiography (OCTA). Materials and Methods: A prospective study was conducted on healthy volunteers, each of whom underwent measurements of intraocular pressure (IOP), central macular thickness (CMT), subfoveal choroidal thickness (SFCT), radial peripapillary capillary perfusion (RPCP), superficial capillary plexus perfusion (SCPP), deep capillary plexus perfusion (DCPP), choriocapillaris perfusion (CCP), Sattler’s layer perfusion (SLP) and Haller’s layer perfusion (HLP) before and after OM. OM was performed for 2 min, consisting of 10-s turns of compression and decompression of the globe. Results: A total of 21 eyes from 21 participants (median age 29) were included. After OM, IOP significantly declined (p < 0.001), while SFCT (p < 0.005), SCPP (p < 0.001), DCPP (p = 0.004) and CCP (p = 0.008) significantly increased. CMT, RPCP, SLP and HLP did not show any significant alteration due to OM. Changes in SCPP correlated positively with changes in CCP and vice versa. Conclusions: OCTA-based analysis in healthy adults following OM demonstrated a significant increase of retinal perfusion values, assumed to be due to failure of autoregulatory mechanisms. These findings may indicate a positive effect of OM as a treatment option for patients with acute retinal artery occlusion.

scholarly journals The impact of three-dimensional optical coherence tomography and kissing-balloon inflation for stent implantation to bifurcation lesions

2016 ◽  
Vol 13 (5) ◽  
pp. 133-136 ◽  
Author(s):  
Hiroshi Koiwaya ◽  
Masao Takemoto ◽  
Kenji Ogata ◽  
Tatsuya Nakama ◽  
Makoto Furugen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Stent Implantation ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Balloon Inflation ◽  
Bifurcation Lesions ◽  
The Impact

scholarly journals Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using a liquid crystal spatial light modulator

2005 ◽  
Vol 45 (28) ◽  
pp. 3432-3444 ◽  
Author(s):  
Enrique J. Fernández ◽  
Boris Považay ◽  
Boris Hermann ◽  
Angelika Unterhuber ◽  
Harald Sattmann ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Liquid Crystal ◽  
Adaptive Optics ◽  
Spatial Light Modulator ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Light Modulator ◽  
Ultrahigh Resolution

scholarly journals Evaluation of Radiation Maculopathy after Treatment of Choroidal Melanoma with Ruthenium-106 using Optical Coherence Tomography Angiography

2021 ◽  
Author(s):  
Ali Torkashvand ◽  
Hamid Riazi-Esfahani ◽  
Fariba Ghassemi ◽  
Elias Khalil Pour ◽  
Babak Masoomian ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Choroidal Melanoma ◽  
Case Series ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Vascular Area ◽  
Capillary Plexus ◽  
The Impact ◽  
Healthy Eyes

Abstract BACKGROUND: To assess the impact of brachytherapy on macular microvasculature utilizing optical coherence tomography angiography (OCTA) in treated choroidal melanoma.METHODS: In this retrospective observational case series, we reviewed the recorded data of the patients with choroidal melanoma treated with rheuthenium-106 (106Ru) plaque radiotherapy with follow-up period of more than 6 months. Automatically measured OCTA retinal parameters were analyzed after image processing. The non-irradiated fellow eye is considered as the control.RESULTS: Thirty-one eyes of 31 patients with the mean age of 51.1 years were recruited. Six eyes had no radiation maculopathy (RM). From 25 eyes with RM, nine eyes (36%) revealed a burnout macular microvasculature with imperceptible vascular details. Foveal and optic disc radiation dose had the highest value to predict the burnout pattern (ROC, AUC: 0.763, 0.727). Superficial and deep foveal avascular zone (FAZ) were larger in irradiated eyes in comparison to healthy eyes (1629 µm2 vs. 428 µm2, P =0.005; 1837 µm2 vs 268 µm2, P =0.021; respectively). Foveal and parafoveal vascular area density (VAD) and vascular skeleton density (VSD) in both superficial and deep capillary plexus (SCP and DCP) were decreased in all irradiated eyes in comparison with control eyes (P< 0.001). Compared with fellow healthy eyes, irradiated eyes without RM had significantly lower VAD and VSD at foveal and parafoveal DCP (all P<0.02). However, these differences at SCP were not statistically significant. CONCLUSION: The OCTA is a valuable tool for evaluating RM. Initial subclinical microvascular insult after 106Ru brachytherapy is more likely to occur in DCP. The deep FAZ area was identified as a more critical biomarker of BCVA than superficial FAZ in these patients.

Three-dimensional assessment of proximal contact enamel using optical coherence tomography

2019 ◽  
Vol 35 (4) ◽  
pp. e74-e82 ◽  
Author(s):  
Thwe Zin Ei ◽  
Yasushi Shimada ◽  
Ahmed Abdou ◽  
Alireza Sadr ◽  
Masahiro Yoshiyama ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Dimensional Assessment

scholarly journals Pilot study for three-dimensional assessment of laminar pore structure in patients with glaucoma, as measured with swept source optical coherence tomography

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207600 ◽  
Author(s):  
Kazuko Omodaka ◽  
Shigeto Maekawa ◽  
Guangzhou An ◽  
Satoru Tsuda ◽  
Yukihiro Shiga ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Pilot Study ◽  
Pore Structure ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Swept Source ◽  
Dimensional Assessment

scholarly journals Impact of large choroidal vessels on choriocapillaris flow deficit analyses in optical coherence tomography angiography

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0254955
Author(s):  
Valentin Hacker ◽  
Gregor Sebastian Reiter ◽  
Markus Schranz ◽  
Reinhard Told ◽  
Adrian Reumüller ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Linear Mixed Model ◽  
Influential Factors ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Age Related ◽  
The Impact ◽  
Choroidal Vessels ◽  
Healthy Eyes

Purpose To investigate the impact of large choroidal vessels (LCV) on Choriocapillaris (CC) flow deficit (FD) analyses with swept-source optical coherence tomography angiography (SS-OCTA) Design Prospective, cross-sectional study. Methods Macular 6x6mm SS-OCTA scans were obtained from intermediate age-related macular degeneration (iAMD) and healthy eyes. Images were captured and processed according to most common standards and analyzed for percentage of flow-deficits (FD%) within four 1x1mm squares at the corners of each image. Choroidal thickness (CT), iris color and refraction error were considered as potential influential factors for LCV visibility. A linear mixed model and logistic regression models were calculated for statistical evaluation. Results Sixty-nine iAMD and 49 age-matched healthy eyes were enrolled. LCV were visible in at least one sector in 52% of iAMD and 47% of healthy eyes. Within the iAMD group FD% were significantly lower in areas containing LCV (p = 0.0029). Increasing CT resulted in an odds ratio decrease of LCV (OR: 0.94, p<0.0001). Below a CT value of ≤118μm LCV could be expected with a sensitivity of 86% and a specificity of 85%. Conclusions LCV can significantly affect CC FD analyses of SS-OCTA images. Their visibility is negatively associated with CT. The impact of LCV should be taken into account when performing CC FD assessments, especially in patients where reduced CT is to be expected and inclusion of affected areas should be considered carefully.

scholarly journals In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa With Adaptive Optics Spectral-Domain Optical Coherence Tomography

2014 ◽  
Vol 55 (10) ◽  
pp. 6459 ◽  
Author(s):  
Zach Nadler ◽  
Bo Wang ◽  
Joel S. Schuman ◽  
R. Daniel Ferguson ◽  
Ankit Patel ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Adaptive Optics ◽  
Three Dimensional ◽  
Lamina Cribrosa ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Healthy Human

THREE-DIMENSIONAL ANALYSIS OF RETINAL MICROANEURYSMS WITH ADAPTIVE OPTICS OPTICAL COHERENCE TOMOGRAPHY

Retina ◽  
2019 ◽  
Vol 39 (3) ◽  
pp. 465-472 ◽  
Author(s):  
Sonja G. Karst ◽  
Matthias Salas ◽  
Julia Hafner ◽  
Christoph Scholda ◽  
Wolf-Dieter Vogl ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Dimensional Analysis ◽  
Adaptive Optics ◽  
Three Dimensional ◽  
Optical Coherence ◽  
Retinal Microaneurysms
Sign in / Sign up

Export Citation Format

Share Document