To obtain high energy, high efficiency Nd: glass preamplifier used in certain host device, a Nd:glass regenerative amplifier system has been designed. By adjusting the single pass gain and carefully optimizing the cavity mode, the small-scale self-focusing effect in the gain medium was effectively controlled. Maximum pulse energy of 21mJ, pulse width of 2.6ns was obtained at the repetition frequency of 1Hz, corresponding to a high optical to optical conversion efficiency of 11% and amplification ratio of 108. The pulse to pulse energy stability was < 2% rms during 2 h continous operation. The laser has a good beam quality of M2=1.5. The spectrum was measured to be at center wavelength of 1052.915nm.