A Compact Accelerator-Based Light Source for High-Power, Full-Bandwidth Tunable Coherent THz Generation

Terahertz (THz) radiation sources are increasingly significant for many scientific frontiers, while the generation of THz radiation with high-power at wide-tunable frequencies is still a limitation for most existing methods. In this paper, a compact accelerator-based light source is proposed to produce coherent THz radiation with high pulse energy and tunable frequency from 0.1 THz to 60 THz. By using a frequency beating laser-modulated electron beam and undulator taper, intense coherent THz radiation can be generated through undulators. Theoretical analysis and numerical simulations demonstrate that the proposed technique can generate narrow-bandwidth THz radiation with a pulse energy up to 6.3 millijoule (mJ) and the three-dimensional effects of beam has limited influence on its performance. The proposed technique will open up new opportunities for THz spectroscopic and time-resolved experiments.

Impact of second-trip echoes for space-borne high-pulse-repetition-frequency nadir-looking W-band cloud radars

The appearance of second-trip echoes generated by mirror images over the ocean and by multiple scattering tails in correspondence with deep convective cores has been investigated for space-borne nadir-looking W-band cloud radar observations. Examples extracted from the CloudSat radar are used to demonstrate the mechanisms of formation and to validate the modelling of such returns. A statistical analysis shows that, for CloudSat observations, second-trip echoes are rare and appear only above 20 km (thus easy to remove). CloudSat climatology is then used to estimate the occurrence of second-trip echoes in the different configurations envisaged for the operations of the EarthCARE radar, which will adopt pulse repetition frequencies much higher than the one used by the CloudSat radar in order to improve its Doppler capabilities. Our findings predict that the presence of such echoes in EarthCARE observations cannot be neglected: in particular, over the ocean, mirror images will tend to populate the EarthCARE sampling window with a maximum frequency at its upper boundary. This will create an additional fake cloud cover in the upper troposphere (of the order of 3 % at the top of the sampling window and steadily decreasing moving downwards), and, in much less frequent instances, it will cause an amplification of signals in areas where clouds are already present. Multiple scattering tails will also produce second-trip echoes but with much lower frequencies: less than 1 profile out of 1000 in the tropics and practically no effects at high latitudes. At the moment, level-2 algorithms of the EarthCARE radar do not account for such occurrences. We recommend to properly remove these second-trip echoes and to correct for reflectivity enhancements, where needed. More generally this work is relevant for the design of future space-borne Doppler W-band radar missions.

Deletion of Gαq/11 or Gαs proteins in gonadotropes differentially affects gonadotropin production and secretion in mice

GnRH regulates gonadal function via its stimulatory effects on gonadotropin production by pituitary gonadotrope cells. GnRH is released from the hypothalamus in pulses and GnRH pulse frequency differentially regulates FSH and LH synthesis and secretion. The GnRH receptor (GnRHR) is a G protein-coupled receptor that canonically activates Gαq/11-dependent signaling upon ligand binding. However, the receptor can also couple to Gαs and in vitro data suggest that toggling between different G proteins may contribute to GnRH pulse frequency decoding. For example, as we show here, knockdown of Gαs impairs GnRH-stimulated FSH synthesis at low, but not high pulse frequency in a model gonadotrope-derived cell line. We next used a Cre-lox conditional knockout approach to interrogate the relative roles of Gαq/11 and Gαs proteins in gonadotrope function in mice. Gonadotrope-specific Gαq/11 knockouts exhibit hypogonadotropic hypogonadism and infertility, akin to the phenotypes seen in GnRH- or GnRHR-deficient mice. In contrast, under standard conditions, gonadotrope-specific Gαs knockouts produce gonadotropins at normal levels and are fertile. However, the LH surge amplitude is blunted in Gαs knockout females and post-gonadectomy increases in FSH and LH are reduced in both males and females. These data suggest that GnRH may signal principally via Gαq/11 to stimulate gonadotropin production, but that Gαs plays important roles in gonadotrope function in vivo when GnRH secretion is enhanced.

A comprehensive study of current-crowding effect in high power vertical AlInGaN LEDs under high pulsed current

The goal of the study is examination of current-crowding effect in high power AlInGaN LEDs. This effect was presented by mapping of EL (electroluminescence) near filed under high pulse current. LED chip of vertical design was study in high range of current (10−9 ÷ 70A). This operating mode of LEDs are interesting for different applications, such as pumping lasers, VLC and LiFi, as well as for investigation accelerated degradation process of LEDs.

A pulse current generator for dense plasma focus

A pulse current generator applied in a type of high-yield intense pulsed neutron source, the Dense Plasma Focus (DPF), is designed and developed in this paper. There are three key components in this generator. Each group of capacitors and switches is integrative to meet the DPF's requirements of low circuit inductance. A coaxial multi-channel switch is developed to solve the problems of the switch inductance, the jitter and the electrode erosion. A kind of sectorial plate transmission line is adopted to transfer the high pulse current from the capacitors to the DPF. The following technical parameters of the generator were achieved on dummy load: output current amplitude of ∼560 kA when primary capacitors are charged with 22 kV.

Femtosecond lasers for eye surgery applications: historical overview and modern low pulse energy concepts

This review provides an overview of the historical development and modern applications of femtosecond (fs) lasers in ophthalmology, with a focus on the optical concepts involved. fs-Laser technology is unique because it allows very precise cutting inside the eye through optically transparent tissue, without a need for any mechanical openings. fs-Lasers were historically first used for refractive cornea surgery, later also for therapeutic cornea procedures and lens surgery. Further new areas of ophthalmic application are under development. The latest laser system concept is low pulse energy and high pulse frequency: by using larger numerical aperture focusing optics, the pulse energy required for optical breakdown decreases, and athermal tissue cutting with minimal side effects is enabled.