scholarly journals Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner

PLoS Biology ◽  
2018 ◽  
Vol 16 (9) ◽  
pp. e2005004 ◽  
Author(s):  
Tomotsune Ameku ◽  
Yuto Yoshinari ◽  
Michael J. Texada ◽  
Shu Kondo ◽  
Kotaro Amezawa ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Germline Stem Cell ◽  
Dependent Manner ◽  
Stem Cell Proliferation ◽  
Neuropeptide F

Two mutations in pab-1 encoding poly(A)-binding protein show similar defects in germline stem cell proliferation but different longevity in C. elegans

2010 ◽  
Vol 30 (2) ◽  
pp. 167-172 ◽  
Author(s):  
Sunny Ko ◽  
Jae-Hyung Park ◽  
Ah-Reum Lee ◽  
Eugene Kim ◽  
Jiyoung-Kim ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Binding Protein ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation ◽  
C Elegans

scholarly journals Wolbachia Enhance Drosophila Stem Cell Proliferation and Target the Germline Stem Cell Niche

Science ◽  
2011 ◽  
Vol 334 (6058) ◽  
pp. 990-992 ◽  
Author(s):  
E. M. Fast ◽  
M. E. Toomey ◽  
K. Panaram ◽  
D. Desjardins ◽  
E. D. Kolaczyk ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation ◽  
Cell Niche ◽  
Germline Stem Cell Niche

PLZF-Induced Upregulation of CXCR4 Promotes Dairy Goat Male Germline Stem Cell Proliferation by Targeting Mir146a

2015 ◽  
Vol 117 (4) ◽  
pp. 844-852 ◽  
Author(s):  
Hailong Mu ◽  
Na Li ◽  
Jiang Wu ◽  
Liming Zheng ◽  
Yuanxin Zhai ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Dairy Goat ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation ◽  
Male Germline

scholarly journals Non-autonomous autophagy in germline stem cell proliferation

Cell Cycle ◽  
2017 ◽  
Vol 16 (16) ◽  
pp. 1481-1482 ◽  
Author(s):  
Kristina Ames ◽  
Alicia Meléndez
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Germline Stem Cell ◽  
Stem Cell Proliferation

Analysis of GPI-anchored proteins involved in germline stem cell proliferation in the Caenorhabditis elegans germline stem cell niche

2020 ◽  
Vol 168 (6) ◽  
pp. 589-602
Author(s):  
Marika Rikitake ◽  
Ayako Matsuda ◽  
Daisuke Murata ◽  
Katsufumi Dejima ◽  
Kazuko H Nomura ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Caenorhabditis Elegans ◽  
Lipid Rafts ◽  
Stem Cell Niche ◽  
Germline Stem Cell ◽  
Self Renewal ◽  
Stem Cell Proliferation ◽  
Cell Niche ◽  
Germline Stem Cell Niche

Abstract Stem cells divide and undergo self-renewal depending on the signals received from the stem cell niche. This phenomenon is indispensable to maintain tissues and organs in individuals. However, not all the molecular factors and mechanisms of self-renewal are known. In our previous study, we reported that glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) synthesized in the distal tip cells (DTCs; the stem cell niche) are essential for germline stem cell proliferation in Caenorhabditis elegans. Here, we characterized the GPI-APs required for proliferation. We selected and verified the candidate GPI-APs synthesized in DTCs by RNA interference screening and found that F57F4.3 (GFI-1), F57F4.4 and F54E2.1 are necessary for germline proliferation. These proteins are likely involved in the same pathway for proliferation and activated by the transcription factor PQM-1. We further provided evidence suggesting that these GPI-APs act through fatty acid remodelling of the GPI anchor, which is essential for association with lipid rafts. These findings demonstrated that GPI-APs, particularly F57F4.3/4 and F54E2.1, synthesized in the germline stem cell niche are located in lipid rafts and involved in promoting germline stem cell proliferation in C. elegans. The findings may thus shed light on the mechanisms by which GPI-APs regulate stem cell self-renewal.

Sign in / Sign up

Export Citation Format

Share Document