scholarly journals The architecture of intra-organism mutation rate variation in plants

PLoS Biology ◽  
2019 ◽  
Vol 17 (4) ◽  
pp. e3000191 ◽  
Author(s):  
Long Wang ◽  
Yilun Ji ◽  
Yingwen Hu ◽  
Huaying Hu ◽  
Xianqin Jia ◽  
...  
Keyword(s):  
Mutation Rate ◽  
Rate Variation ◽  
Mutation Rate Variation

Minisatellite mutation rate variation associated with a flanking DNA sequence polymorphism

1994 ◽  
Vol 8 (2) ◽  
pp. 162-170 ◽  
Author(s):  
Darren G. Monckton ◽  
Rita Neumann ◽  
Tara Guram ◽  
Neale Fretwell ◽  
Keiji Tamaki ◽  
...  
Keyword(s):  
Dna Sequence ◽  
Mutation Rate ◽  
Sequence Polymorphism ◽  
Rate Variation ◽  
Dna Sequence Polymorphism ◽  
Mutation Rate Variation

scholarly journals Reply to: Mutation rate variation in eukaryotes: evolutionary implications of site-specific mechanisms

2007 ◽  
Vol 8 (11) ◽  
pp. 902-902
Author(s):  
Charles F. Baer ◽  
Michael M. Miyamoto ◽  
Dee R. Denver
Keyword(s):  
Mutation Rate ◽  
Rate Variation ◽  
Site Specific ◽  
Mutation Rate Variation

scholarly journals Robustness of Coalescent Estimators to Between-Lineage Mutation Rate Variation

2006 ◽  
Vol 23 (12) ◽  
pp. 2355-2360 ◽  
Author(s):  
M. K. Kuhner
Keyword(s):  
Mutation Rate ◽  
Rate Variation ◽  
Mutation Rate Variation

scholarly journals Mutation Rate Variability across Human Y-Chromosome Haplogroups

2020 ◽  
Author(s):  
Qiliang Ding ◽  
Ya Hu ◽  
Amnon Koren ◽  
Andrew G Clark
Keyword(s):  
Y Chromosome ◽  
Mutation Rate ◽  
Cultured Cells ◽  
Sex Chromosome ◽  
Branch Length ◽  
Rate Variation ◽  
Sequencing Data ◽  
Chromosome Mutations ◽  
Mutation Rate Variation

Abstract A common assumption in dating patrilineal events using Y-chromosome sequencing data is that the Y-chromosome mutation rate is invariant across haplogroups. Previous studies revealed interhaplogroup heterogeneity in phylogenetic branch length. Whether this heterogeneity is caused by interhaplogroup mutation rate variation or nongenetic confounders remains unknown. Here, we analyzed whole-genome sequences from cultured cells derived from >1,700 males. We confirmed the presence of branch length heterogeneity. We demonstrate that sex-chromosome mutations that appear within cell lines, which likely occurred somatically or in vitro (and are thus not influenced by nongenetic confounders) are informative for germline mutational processes. Using within-cell-line mutations, we computed a relative Y-chromosome somatic mutation rate, and uncovered substantial variation (up to 83.3%) in this proxy for germline mutation rate among haplogroups. This rate positively correlates with phylogenetic branch length, indicating that interhaplogroup mutation rate variation is a likely cause of branch length heterogeneity.

scholarly journals Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation

Science ◽  
2016 ◽  
Vol 351 (6277) ◽  
pp. 1094-1097 ◽  
Author(s):  
S. Uphoff ◽  
N. D. Lord ◽  
B. Okumus ◽  
L. Potvin-Trottier ◽  
D. J. Sherratt ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Damage Response ◽  
Mutation Rate ◽  
Rate Variation ◽  
Cell Mutation ◽  
Damage Response ◽  
Mutation Rate Variation

Mutation rate variation in the mammalian genome

2003 ◽  
Vol 13 (6) ◽  
pp. 562-568 ◽  
Author(s):  
Hans Ellegren ◽  
Nick GC Smith ◽  
Matthew T Webster
Keyword(s):  
Mutation Rate ◽  
Mammalian Genome ◽  
Rate Variation ◽  
Mutation Rate Variation

scholarly journals Mutation Rate Variation is a Primary Determinant of the Distribution of Allele Frequencies in Humans

PLoS Genetics ◽  
2016 ◽  
Vol 12 (12) ◽  
pp. e1006489 ◽  
Author(s):  
Arbel Harpak ◽  
Anand Bhaskar ◽  
Jonathan K. Pritchard
Keyword(s):  
Mutation Rate ◽  
Allele Frequencies ◽  
Rate Variation ◽  
Primary Determinant ◽  
Mutation Rate Variation
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