scholarly journals Recovery from an Acute Infection in C. elegans Requires the GATA Transcription Factor ELT-2

PLoS Genetics ◽  
2014 ◽  
Vol 10 (10) ◽  
pp. e1004609 ◽  
Author(s):  
Brian Head ◽  
Alejandro Aballay
Keyword(s):  
Transcription Factor ◽  
Acute Infection ◽  
C Elegans ◽  
Gata Transcription Factor

Re-evaluating the role of ELT-3 in a GATA transcription factor circuit proposed to guide aging in C. elegans

2012 ◽  
Vol 133 (1) ◽  
pp. 50-53 ◽  
Author(s):  
Tabitha Tonsaker ◽  
Ryan M. Pratt ◽  
James D. McGhee
Keyword(s):  
Transcription Factor ◽  
C Elegans ◽  
Gata Transcription Factor

scholarly journals Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans

PLoS Genetics ◽  
2016 ◽  
Vol 12 (4) ◽  
pp. e1005956 ◽  
Author(s):  
Frederick G. Mann ◽  
Eric L. Van Nostrand ◽  
Ari E. Friedland ◽  
Xiao Liu ◽  
Stuart K. Kim
Keyword(s):  
Transcription Factor ◽  
Normal Aging ◽  
C Elegans ◽  
Gata Transcription Factor

scholarly journals The C. elegans GATA transcription factor elt-2 mediates distinct transcriptional responses and opposite infection outcomes towards different Bacillus thuringiensis strains

2020 ◽  
Vol 16 (9) ◽  
pp. e1008826
Author(s):  
Alejandra Zárate-Potes ◽  
Wentao Yang ◽  
Barbara Pees ◽  
Rebecca Schalkowski ◽  
Philipp Segler ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Bacillus Thuringiensis ◽  
Transcriptional Responses ◽  
C Elegans ◽  
Gata Transcription Factor

scholarly journals Role of GATA transcription factor ELT-2 and p38 MAPK PMK-1 in recovery from acute P. aeruginosa infection in C. elegans

Virulence ◽  
2016 ◽  
Vol 8 (3) ◽  
pp. 261-274 ◽  
Author(s):  
Brian P. Head ◽  
Abiola O. Olaitan ◽  
Alejandro Aballay
Keyword(s):  
Transcription Factor ◽  
P38 Mapk ◽  
C Elegans ◽  
Gata Transcription Factor

scholarly journals SREB, a GATA Transcription Factor That Directs Disparate Fates in Blastomyces dermatitidis Including Morphogenesis and Siderophore Biosynthesis

2010 ◽  
Vol 6 (4) ◽  
pp. e1000846 ◽  
Author(s):  
Gregory M. Gauthier ◽  
Thomas D. Sullivan ◽  
Sergio S. Gallardo ◽  
T. Tristan Brandhorst ◽  
Amber J. Vanden Wymelenberg ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Blastomyces Dermatitidis ◽  
Siderophore Biosynthesis ◽  
Gata Transcription Factor

scholarly journals Specific collagens maintain the cuticle permeability barrier in Caenorhabditis elegans

Genetics ◽  
2021 ◽  
Author(s):  
Anjali Sandhu ◽  
Divakar Badal ◽  
Riya Sheokand ◽  
Shalini Tyagi ◽  
Varsha Singh
Keyword(s):  
Transcription Factor ◽  
Caenorhabditis Elegans ◽  
Barrier Function ◽  
Permeability Barrier ◽  
Nematode Caenorhabditis Elegans ◽  
Zinc Finger Transcription Factor ◽  
Outermost Layer ◽  
C Elegans ◽  
Receptor Mutant ◽  
Antioxidant Machinery

Abstract Collagen enriched cuticle forms the outermost layer of skin in nematode Caenorhabditis elegans. The nematode’s genome encodes 177 collagens, but little is known about their role in maintaining the structure or barrier function of the cuticle. In this study, we found six permeability determining (PD) collagens. Loss of any of these PD collagens- DPY-2, DPY-3, DPY-7, DPY-8, DPY-9, and DPY-10- led to enhanced susceptibility of nematodes to paraquat (PQ) and antihelminthic drugs levamisole and ivermectin. Upon exposure to paraquat, PD collagen mutants accumulated more PQ and incurred more damage and death despite the robust activation of antioxidant machinery. We find that BLMP-1, a zinc finger transcription factor, maintains the barrier function of the cuticle by regulating the expression of PD collagens. We show that the permeability barrier maintained by PD collagens acts in parallel to FOXO transcription factor DAF-16 to enhance survival of insulin-like receptor mutant, daf-2. In all, this study shows that PD collagens regulate cuticle permeability by maintaining the structure of C. elegans cuticle and thus provide protection against exogenous toxins.

scholarly journals C. elegans sym-1is a downstream target of the Hunchback-like-1 developmental timing transcription factor

Cell Cycle ◽  
2009 ◽  
Vol 8 (24) ◽  
pp. 4147-4154 ◽  
Author(s):  
Ryusuke Niwa ◽  
Kazumasa Hada ◽  
Kouichi Moliyama ◽  
Ryosuke L. Ohniwa ◽  
Yi-Meng Tan ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Developmental Timing ◽  
C Elegans ◽  
Downstream Target
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